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MedKoo Cat#: 326658 | Name: Splenopentin acetate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Splenopentin, also known as SP-5, is a synthetic immunomodulating peptide corresponding to the region 32-34 of a splenic product called splenin (SP) and the thymic hormone thymopoietin (TP), respectively. Splenopentin can reproduce the biological activities of TP and SP, respectively.

Chemical Structure

Splenopentin acetate
Splenopentin acetate
CAS#105184-37-0 (acetate)

Theoretical Analysis

MedKoo Cat#: 326658

Name: Splenopentin acetate

CAS#: 105184-37-0 (acetate)

Chemical Formula: C35H59N9O13

Exact Mass: 0.0000

Molecular Weight: 813.91

Elemental Analysis: C, 51.65; H, 7.31; N, 15.49; O, 25.55

Price and Availability

Size Price Availability Quantity
100mg USD 100.00
200mg USD 150.00
500mg USD 250.00
1g USD 450.00
2g USD 850.00
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Related CAS #
105184-37-0 (Acetate) 75957-60-7 (free base)
Synonym
SP5; Arg-lys-glu-val-tyr; Splenin pentapeptide (32-36); Thymopoietin III pentapeptide (32-36); Splenopentin diacetate
IUPAC/Chemical Name
(6S,9S,12S,15S,18S)-1,6-diamino-9-(4-aminobutyl)-12-(2-carboxyethyl)-18-(4-hydroxybenzyl)-1-imino-15-isopropyl-7,10,13,16-tetraoxo-2,8,11,14,17-pentaazanonadecan-19-oic acid compound with acetic acid (1:1)
InChi Key
LVTBFNOBCJAFQW-VPPHCPGPSA-N
InChi Code
InChI=1S/C31H51N9O9.C2H4O2/c1-17(2)25(29(47)39-23(30(48)49)16-18-8-10-19(41)11-9-18)40-28(46)22(12-13-24(42)43)38-27(45)21(7-3-4-14-32)37-26(44)20(33)6-5-15-36-31(34)35;1-2(3)4/h8-11,17,20-23,25,41H,3-7,12-16,32-33H2,1-2H3,(H,37,44)(H,38,45)(H,39,47)(H,40,46)(H,42,43)(H,48,49)(H4,34,35,36);1H3,(H,3,4)/t20-,21-,22-,23-,25-;/m0./s1
SMILES Code
O=C(O)[C@H](Cc1ccc(O)cc1)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)N)=O)=O)=O)=O.CC(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Splenopentin can reproduce the biological activities of TP and SP, respectively.
In vitro activity:
To be determined
In vivo activity:
To be determined

Preparing Stock Solutions

The following data is based on the product molecular weight 813.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
To be determined
In vitro protocol:
To be determined
In vivo protocol:
To be determined
1: Onoue S, Liu B, Nemoto Y, Hirose M, Yajima T. Chemical synthesis and application of C-terminally 5-carboxyfluorescein-labelled thymopentin as a fluorescent probe for thymopoietin receptor. Anal Sci. 2006 Dec;22(12):1531-5. doi: 10.2116/analsci.22.1531. PMID: 17159311. 2: Singh VK, Biswas S, Mathur KB, Haq W, Garg SK, Agarwal SS. Thymopentin and splenopentin as immunomodulators. Current status. Immunol Res. 1998;17(3):345-68. doi: 10.1007/BF02786456. PMID: 9638477. 3: Dikler S, Kelly JW, Russell DH. Improving mass spectrometric sequencing of arginine-containing peptides by derivatization with acetylacetone. J Mass Spectrom. 1997 Dec;32(12):1337-49. doi: 10.1002/(SICI)1096-9888(199712)32:12<1337::AID-JMS599>3.0.CO;2-X. PMID: 9423284. 4: Biswas S, Singh VK, Rastogi A, Sharan R, Haq W, Mathur KB, Agarwal SS. Stimulation of IL-2 production and CD2R expression by splenopentin analogs. Int J Immunopharmacol. 1997 Jun;19(6):341-5. doi: 10.1016/s0192-0561(97)00032-5. PMID: 9467753. 5: Chatterjee-Kishore M, Agrawal S, Singh VK, Mathur KB, Haq A, Agarwal SS. Upregulation of HLA class-I gene transcription in K562 cells by analogs of splenopentin (SP-5). Biochem Mol Biol Int. 1997 Mar;41(3):521-8. doi: 10.1080/15216549700201541. Erratum in: Biochem Mol Biol Int 1997 Oct;43(2):463. PMID: 9090459. 6: Chen M, Waldron KC, Zhao Y, Dovichi NJ. Micellar capillary electrophoresis separation and thermo-optical absorbance detection of products from manual peptide sequencing. Electrophoresis. 1994 Oct;15(10):1290-4. doi: 10.1002/elps.11501501196. PMID: 7895721. 7: Mizutani S, Goto K, Nomura S, Ino K, Goto S, Kikkawa F, Kurauchi O, Goldstein G, Tomoda Y. Possible action of human placental aminopeptidase N in feto- placental unit. Res Commun Chem Pathol Pharmacol. 1993 Oct;82(1):65-80. PMID: 7903813. 8: Diezel W, Weber HA, Maciejewski J, Volk HD. The effect of splenopentin (DA SP-5) on in vitro myelopoiesis and on AZT-induced bone marrow toxicity. Int J Immunopharmacol. 1993 Apr;15(3):269-73. doi: 10.1016/0192-0561(93)90035-w. PMID: 8505137. 9: Liebermann HT, Thalmann G, Bartels T, Nöckler A. Experiments on an early protection against foot-and-mouth disease virus. Acta Virol. 1993 Apr- Jun;37(2-3):181-3. PMID: 8105663. 10: Rastogi A, Singh VK, Biswas S, Haq W, Mathur KB, Agarwal SS. Augmentation of human natural killer cells by splenopentin analogs. FEBS Lett. 1993 Feb 8;317(1-2):93-5. doi: 10.1016/0014-5793(93)81498-o. PMID: 8428639. 11: Bräuer R, Egg AJ, Henzgen S, Kriegsmann J, Thoss K. The effects of immunomodulatory thymic and splenic peptides and cyclosporin A on antigen- induced arthritis in the rat. Agents Actions. 1993;38 Spec No:C95-7. doi: 10.1007/BF01991149. PMID: 8317333. 12: Simon HU, Kraul H, Schäfer R, Kilian U, Hoffmann A. Lack of effect of diacetyl-splenopentin (Berlopentin) on the pharmacokinetics of caffeine. Pharmazie. 1992 Jan;47(1):49-50. PMID: 1608985. 13: Bräuer R, Thoss K, Henzgen S, Waldmann G. Effects of the immunomodulator diacetyl-splenopentin on antigen-induced arthritis in rabbits. Agents Actions. 1992 Jan;35(1-2):96-103. doi: 10.1007/BF01990958. PMID: 1387284. 14: Evseev VA, Davydova TV, Fomina VG, Odariuk Iu, Repke G, Oeme P, Forner K. Splenopentin--moduliator immunnykh i povedencheskikh reaktsiĭ pri vtorichnom immunodefitsitnom sostoianii, vyzvannom éksperimental'nym alkogolizmom [Splenopentin--modulator of immunological and behavioral reactions in secondary immunodeficiency state induced by experimental alcoholism]. Biull Eksp Biol Med. 1991 Jun;111(6):637-9. Russian. PMID: 1893194. 15: Baumgart J, Zippel D. Age-dependent experimental tumor dissemination of murine melanoma B16. Arch Immunol Ther Exp (Warsz). 1991;39(5-6):489-94. PMID: 1841547. 16: Simon HU, Forner K, Büttner A, Haroske D, Vogt KH. Der Lymphozytentransformationstest unter Verwendung von mononukleären Zellen alter Menschen als geeignete in vitro-Methode zur Testung von Struktur-Wirkungs- Beziehungen von Splenin-Peptiden [The lymphocyte transformation test using mononuclear cells of elderly humans as a suitable in vitro method for testing of structure activity relationships of splenin peptides]. Pharmazie. 1990 Dec;45(12):917-9. German. PMID: 2100799. 17: Simon HU, Lauterbach H, Börner A, Wachtel S. Diacetyl-splenopentin (BCH 069) did not affect the concentrations of various hormones in men. Exp Clin Endocrinol. 1990 Dec;96(3):314-6. doi: 10.1055/s-0029-1211025. PMID: 2083571. 18: Eckert R, Maciejewski J, Weber H, Volk HD, Diezel W, Forner K, von Baehr R. Splenopentin (DAc-SP5)--influence on engraftment and graft-vs-host reaction after non-H-2 bone marrow transplantation in mice. Exp Clin Endocrinol. 1990 Dec;96(3):307-13. doi: 10.1055/s-0029-1211024. PMID: 2083570. 19: Maciejewski J, Wächter M, Elstner E, Weber H, Diezel W, Seiler FR, Volk HD. Cytofluorometric and cytomorphologic analysis of human bone marrow cells derived from stromal cultures stimulated by granulocyte-macrophage colony-stimulating factor, interferon-gamma and splenopentin pentapeptide. Eur J Immunol. 1990 Jun;20(6):1209-13. doi: 10.1002/eji.1830200603. PMID: 2114995. 20: Simon HU, Metzner G, Vogt WE, Piesch C, Forner K, Schlenvoigt G, Storz H, Haroske D, Jäger L. Clinical, biochemical and immunological effectiveness of diacetyl-splenopentin (BCH 069) in hay fever. Allergol Immunopathol (Madr). 1990 May-Jun;18(3):155-60. PMID: 2251976.

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BMPPB-32

BMPPB-32