CB 3703 | CAS#32093-09-7

MedKoo Cat#: 524560 | Name: CB 3703

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CB 3703 is an inhibitor of dihydrofolate reductase and thymidylate synthetase.

Chemical Structure

CB 3703

CAS#32093-09-7

Theoretical Analysis

MedKoo Cat#: 524560

Name: CB 3703

CAS#: 32093-09-7

Chemical Formula: C22H24N6O5

Exact Mass: 452.1808

Molecular Weight: 452.46

Elemental Analysis: C, 58.40; H, 5.35; N, 18.57; O, 17.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

CB 3703; CB3703; CB-3703; NSC 289522.

IUPAC/Chemical Name

N-(p-(((2,4-Diamino-5-methyl-6-quinazolinyl)methyl)amino)benzoyl)-L-glutamic acid

InChi Key

GNFFWMJNLXIQMI-MRXNPFEDSA-N

InChi Code

InChI=1S/C22H24N6O5/c1-11-13(4-7-15-18(11)19(23)28-22(24)27-15)10-25-14-5-2-12(3-6-14)20(31)26-16(21(32)33)8-9-17(29)30/h2-7,16,25H,8-10H2,1H3,(H,26,31)(H,29,30)(H,32,33)(H4,23,24,27,28)/t16-/m1/s1

SMILES Code

n1c(c2c(c(CNc3ccc(C(N[C@@H](C(=O)O)CCC(=O)O)=O)cc3)ccc2nc1N)C)N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 452.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sikora F, Grzelakowska-Sztabert B. Quinazoline CB 3717 and CB 3703 inhibition of folate retention and metabolism in Ehrlich ascites carcinoma cells and some organs of the host-mouse. Cancer Lett. 1984 Jul;23(3):289-95. PubMed PMID: 6744253. 2: Sikora E, Grzelakowska-Sztabert B. A quinazoline antifolate as inhibitor of folate metabolism in mouse L-cells. Acta Biochim Pol. 1983;30(2):193-201. PubMed PMID: 6868908. 3: Grzelakowska-Sztabert B, Balińska M, Chmurzyńska W, Manteuffel-Cymborowska M, Zielińska ZM. Target and non-target metabolic effects of aminofolates and of a 5-methylquinazoline antifolate in mouse cells. Biochem Pharmacol. 1980 Oct 15;29(20):2741-9. PubMed PMID: 7437080. 4: Calvert AH, Jones TR, Dady PJ, Grzelakowska-Sztabert B, Paine RM, Taylor GA, Harrap KR. Quinazoline antifolates with dual biochemical loci of action. Biochemical and biological studies directed towards overcoming methotrexate resistance. Eur J Cancer. 1980 May;16(5):713-22. PubMed PMID: 7389797.