GR-71251 | CAS# 127493-01-0 | Biochemical

MedKoo Cat#: 575966 | Name: GR-71251

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GR-71251 is a Tachykinin receptor antagonist.

Chemical Structure

GR-71251

CAS#127493-01-0

Theoretical Analysis

MedKoo Cat#: 575966

Name: GR-71251

CAS#: 127493-01-0

Chemical Formula: C74H105N19O13

Exact Mass: 1467.8139

Molecular Weight: 1468.77

Elemental Analysis: C, 60.51; H, 7.21; N, 18.12; O, 14.16

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

GR-71,251; GR 71251; GR71251; GR-71251

IUPAC/Chemical Name

(S)-2-((S)-1-(L-arginyl-L-prolyl-L-lysyl)pyrrolidine-2-carboxamido)-N1-((S)-5-amino-1-(((S)-1-(((S)-1-((S)-7-((S)-1-(((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-6-oxo-1,7-diazaspiro[4.4]nonan-1-yl)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1,5-dioxopentan-2-yl)pentanediamide

InChi Key

HUFYSTDJMGIFCD-ZUJDVMCGSA-N

InChi Code

InChI=1S/C74H105N19O13/c1-44(2)39-59(68(102)87-54(62(79)96)42-47-43-83-50-23-10-9-21-48(47)50)92-38-32-74(72(92)106)31-16-37-93(74)71(105)56(41-46-19-7-4-8-20-46)89-65(99)55(40-45-17-5-3-6-18-45)88-64(98)51(27-29-60(77)94)84-63(97)52(28-30-61(78)95)85-66(100)58-26-15-36-91(58)70(104)53(24-11-12-33-75)86-67(101)57-25-14-35-90(57)69(103)49(76)22-13-34-82-73(80)81/h3-10,17-21,23,43-44,49,51-59,83H,11-16,22,24-42,75-76H2,1-2H3,(H2,77,94)(H2,78,95)(H2,79,96)(H,84,97)(H,85,100)(H,86,101)(H,87,102)(H,88,98)(H,89,99)(H4,80,81,82)/t49-,51-,52-,53-,54-,55-,56-,57-,58-,59-,74-/m0/s1

SMILES Code

CC(C)C[C@H](N1CC[C@@]2(CCCN2C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]5CCCN5C(=O)[C@H](CCCCN)NC(=O)[C@@H]6CCCN6C(=O)[C@@H](N)CCCNC(=N)N)C1=O)C(=O)N[C@@H](Cc7c[nH]c8ccccc78)C(=O)N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,468.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Guo JZ, Yoshioka K, Yanagisawa M, Hosoki R, Hagan RM, Otsuka M. Depression of primary afferent-evoked responses by GR71251 in the isolated spinal cord of the neonatal rat. Br J Pharmacol. 1993 Nov;110(3):1142-8. doi: 10.1111/j.1476-5381.1993.tb13933.x. PMID: 7507777; PMCID: PMC2175801. 2. Millet R, Goossens L, Bertrand-Caumont K, Goossens JF, Houssin R, Hénichart JP. A flexible approach to the design of new potent substance P receptor ligands. J Pharm Pharmacol. 2001 Jul;53(7):929-34. doi: 10.1211/0022357011776324. PMID: 11480541. 3. Kurihara T, Yoshioka K, Otsuka M. Tachykininergic slow depolarization of motoneurones evoked by descending fibres in the neonatal rat spinal cord. J Physiol. 1995 Jun 15;485 ( Pt 3)(Pt 3):787-96. doi: 10.1113/jphysiol.1995.sp020769. PMID: 7562617; PMCID: PMC1158044.