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MedKoo Cat#: 524458 | Name: BMS-247243

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BMS-247243 is a novel cephalosporin inhibitory for methicillin-resistant staphylococci. It primarily has activity against gram-positive bacteria. BMS-247243 also inhibits many inherently vancomycin-resistant species (Leuconstoc, Lactobacillus, Pediococcus) and anaerobic gram-positive bacteria.

Chemical Structure

BMS-247243
BMS-247243
CAS#307316-55-8

Theoretical Analysis

MedKoo Cat#: 524458

Name: BMS-247243

CAS#: 307316-55-8

Chemical Formula: C36H41Cl2N5O8S3

Exact Mass: 837.1494

Molecular Weight: 838.84

Elemental Analysis: C, 51.55; H, 4.93; Cl, 8.45; N, 8.35; O, 15.26; S, 11.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BMS-247243; BMS 247243; BMS247243; UNII-KG8365V22L.
IUPAC/Chemical Name
(6R,7R)-7-(2-((4-((E)-3-((carboxylatomethyl)amino)-3-oxoprop-1-en-1-yl)-2,5-dichlorophenyl)thio)acetamido)-3-(((2,6-dimethyl-1-(3-(4-methylmorpholino-4-ium)propyl)pyridin-1-ium-4-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChi Key
MOYDKLWHWUTKTI-LDCQLTLFSA-N
InChi Code
InChI=1S/C36H41Cl2N5O8S3/c1-21-13-25(14-22(2)41(21)7-4-8-43(3)9-11-51-12-10-43)52-18-24-19-54-35-32(34(48)42(35)33(24)36(49)50)40-30(45)20-53-28-16-26(37)23(15-27(28)38)5-6-29(44)39-17-31(46)47/h5-6,13-16,32,35H,4,7-12,17-20H2,1-3H3,(H2-2,39,40,44,45,46,47,49,50)/b6-5+/t32-,35-/m1/s1
SMILES Code
Cc1cc(cc([n+]1CCC[N+]2(CCOCC2)C)C)SCC3=C(N4[C@@H]([C@@H](C4=O)NC(=O)CSc5cc(c(cc5Cl)/C=C/C(=O)NCC(=O)[O-])Cl)SC3)C(=O)[O-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 838.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shahid M, Sobia F, Singh A, Malik A, Khan HM, Jonas D, Hawkey PM. Beta-lactams and beta-lactamase-inhibitors in current- or potential-clinical practice: a comprehensive update. Crit Rev Microbiol. 2009;35(2):81-108. doi: 10.1080/10408410902733979. Review. PubMed PMID: 19514910. 2: Clark J, Fung-Tomc JC, Minassian B, Tsai YH, Yang H, Huczko E, Kolek B, Chaniewski S, Ferraro C, Drain R, Gradelski E, Bonner DP. In vitro and in vivo activities of a novel cephalosporin, BMS-247243, against organisms other than staphylococci. Antimicrob Agents Chemother. 2002 Apr;46(4):1108-11. PubMed PMID: 11897599; PubMed Central PMCID: PMC127083. 3: Fung-Tomc JC, Clark J, Minassian B, Pucci M, Tsai YH, Gradelski E, Lamb L, Medina I, Huczko E, Kolek B, Chaniewski S, Ferraro C, Washo T, Bonner DP. In vitro and in vivo activities of a novel cephalosporin, BMS-247243, against methicillin-resistant and -susceptible staphylococci. Antimicrob Agents Chemother. 2002 Apr;46(4):971-6. PubMed PMID: 11897577; PubMed Central PMCID: PMC127082. 4: Johnson AP. Anti-MRSA cephalosporins Bristol-Myers Squibb. Curr Opin Investig Drugs. 2001 Feb;2(2):205-8. Review. PubMed PMID: 11816831.