MedKoo Cat#: 463063 | Name: SGC-CK2-1N

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SGC-CK2-1N is a negative control for SGC-CK2-1. SGC-CK2-1 is a novel potent CK2 inhibitor, showing equal potency in binding to both catalytic subunits of CK2: CK2α (CSNK2A1) and CK2α' (CSNK2A2). This compound shows equal potency in binding to both catalytic subunits of CK2: CK2α (CSNK2A1) and CK2α' (CSNK2A2). Casein kinase 2 (CK2) is highly expressed in cancer and has been considered a potential therapeutic target.

Chemical Structure

SGC-CK2-1N
SGC-CK2-1N
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 463063

Name: SGC-CK2-1N

CAS#: unknown

Chemical Formula: C23H24N6O

Exact Mass: 400.2012

Molecular Weight: 400.49

Elemental Analysis: C, 68.98; H, 6.04; N, 20.99; O, 3.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SGC-CK2-1N; SGCCK2-1N; SGC CK2-1N; SGC-CK2-1N; SGC-CK21N; SGC-CK2 1N;
IUPAC/Chemical Name
N-(5-((3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyridin-5-yl)amino)-2-methylphenyl)-N-methylcyclopropanecarboxamide
InChi Key
ZVXNQKFYUUXZTK-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H24N6O/c1-14-3-6-18(9-20(14)28(2)23(30)15-4-5-15)26-19-10-21-16(12-24)13-25-29(21)22(11-19)27-17-7-8-17/h3,6,9-11,13,15,17,26-27H,4-5,7-8H2,1-2H3
SMILES Code
CC1=CC=C(NC2=CC3=C(C#N)C=NN3C(NC4CC4)=C2)C=C1N(C)C(C5CC5)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 400.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Licciardello MP, Workman P. A New Chemical Probe Challenges the Broad Cancer Essentiality of CK2. Trends Pharmacol Sci. 2021 May;42(5):313-315. doi: 10.1016/j.tips.2021.02.002. Epub 2021 Mar 23. PMID: 33771354. 2: Wells CI, Drewry DH, Pickett JE, Tjaden A, Krämer A, Müller S, Gyenis L, Menyhart D, Litchfield DW, Knapp S, Axtman AD. Development of a potent and selective chemical probe for the pleiotropic kinase CK2. Cell Chem Biol. 2021 Apr 15;28(4):546-558.e10. doi: 10.1016/j.chembiol.2020.12.013. Epub 2021 Jan 22. PMID: 33484635.