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MedKoo Cat#: 524315 | Name: Avridine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Avridine is a potent synthetic adjuvant that can induce arthritis. It is an immunomodulator and interferon-inducing agent.

Chemical Structure

Avridine
Avridine
CAS#35607-20-6

Theoretical Analysis

MedKoo Cat#: 524315

Name: Avridine

CAS#: 35607-20-6

Chemical Formula: C43H90N2O2

Exact Mass: 666.7002

Molecular Weight: 667.19

Elemental Analysis: C, 77.41; H, 13.60; N, 4.20; O, 4.80

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 750.00 2 Weeks
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Related CAS #
No Data
Synonym
Avridine; CP 20961; CP-20,961; Avridine; CP20961; UNII-P9J7O7YNSW; Avridinum [Latin]; BRN 2227682; BRN2227682; BRN-2227682
IUPAC/Chemical Name
Ethanol, 2,2'-((3-(dioctadecylamino)propyl)imino)bis-
InChi Key
WXNRAKRZUCLRBP-UHFFFAOYSA-N
InChi Code
InChI=1S/C43H90N2O2/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-36-44(38-35-39-45(40-42-46)41-43-47)37-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h46-47H,3-43H2,1-2H3
SMILES Code
N(CCCN(CCO)CCO)(CCCCCCCCCCCCCCCCCC)CCCCCCCCCCCCCCCCCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 667.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Vingsbo C, Jonsson R, Holmdahl R. Avridine-induced arthritis in rats; a T cell-dependent chronic disease influenced both by MHC genes and by non-MHC genes. Clin Exp Immunol. 1995 Mar;99(3):359-63. doi: 10.1111/j.1365-2249.1995.tb05558.x. PMID: 7882557; PMCID: PMC1534209. 2: Brun JG, Håland G, Haga HJ, Fagerhol MK, Jonsson R. Effects of calprotectin in avridine-induced arthritis. APMIS. 1995 Mar;103(3):233-40. doi: 10.1111/j.1699-0463.1995.tb01100.x. PMID: 7755980. 3: Fatunmbi OO, Newman JA, Sivanandan V, Halvorson DA. Enhancement of antibody response of turkeys to trivalent avian influenza vaccine by positively charged liposomal avridine adjuvant. Vaccine. 1992;10(9):623-6. doi: 10.1016/0264-410x(92)90444-o. PMID: 1502840. 4: Rweyemamu MM, Umehara O, de Lucca-Neto D, Baltazar MC, Vicente FE, Medeiros- Neto Rda R. Efficacy of avridine as an adjuvant for Newcastle disease virus antigen in chickens. Am J Vet Res. 1986 Jun;47(6):1243-8. PMID: 3729124. 5: Exon JH, Henningsen GM, Koller LD, Talcott PA. The selectivity of isoprinosine, NPT 15392, avridine and cyclophosphamide on multiple immune responses in rats. Int J Immunopharmacol. 1986;8(1):53-62. doi: 10.1016/0192-0561(86)90073-1. PMID: 2420733. 6: Megid J, Peraçolli MT, Curi PR, Zanetti CR, Cabrera WH, Vassao R, Ito FH. Effect of the bacillus of Calmette-Guérin, Propionibacter acnes and avridine as immunomodulators in antirabies vaccination of mice using the Fuenzalida-Palacios mouse brain vaccine. Vaccine. 1999 May 14;17(19):2446-52. doi: 10.1016/s0264-410x(98)00465-4. PMID: 10392627. 7: Roth JA, Kaeberle ML. Enhancement of lymphocyte blastogenesis and neutrophil function by avridine in dexamethasone-treated and nontreated cattle. Am J Vet Res. 1985 Jan;46(1):53-7. PMID: 3970443. 8: Berinstein A, Pérez Filgueira M, Schudel A, Zamorano P, Borca M, Sadir A. Avridine and LPS from Brucella ovis: effect on the memory induced by foot-and- mouth disease virus vaccination in mice. Vaccine. 1993 Oct;11(13):1295-301. doi: 10.1016/0264-410x(93)90098-i. PMID: 8296482. 9: Sadir AM, Zamorano PI, Romera A, Wigdorovitz A, Smitsaart E, Marangunich L, Schiappacassi C, Borca MV. Improvement of the immune response to foot and mouth disease virus vaccine in calves by using Avridine as adjuvant. Vet Immunol Immunopathol. 1999 Jul 1;69(1):11-22. doi: 10.1016/s0165-2427(99)00035-5. PMID: 10490231. 10: Talcott PA, Koller LD, Woodard LF, Whitbeck GA. Opposing effects of the interferon inducer, avridine: enhancement or suppression of tumor growth depending on treatment regimen. Int J Immunopharmacol. 1986;8(6):553-9. doi: 10.1016/0192-0561(86)90025-1. PMID: 2432025. 11: Côrtes JA, Rweyemamu MM, Ito FH, Umehara O, Medeiros Neto RR, De Lucca-Neto D, Baltazar MC, Vasconcellos SA, Vasconcellos ME. Immune response in cattle induced by inactivated rabies vaccine adjuvanted with aluminium hydroxide either alone or in combination with avridine. Rev Sci Tech. 1993 Sep;12(3):941-55. doi: 10.20506/rst.12.3.726. PMID: 8219344. 12: Knudsen RC, Card DM, Hoffman WW. Protection of guinea pigs against local and systemic foot-and-mouth disease after administration of synthetic lipid amine (Avridine) liposomes. Antiviral Res. 1986 Mar;6(2):123-33. doi: 10.1016/0166-3542(86)90032-x. PMID: 3010856. 13: Pérez Filgueira DM, Wigdorovitz A, Zamorano PI, Ostermann W, Fernández FM, Romera A, Borca MV, Sadir AM. Effect of Mycobacterium sp. wall and Avridine on the antibody response, IgG isotype profile and proliferative response induced by foot and mouth disease virus (FMDV) vaccination in cattle. Vaccine. 1999 Jan 28;17(4):345-52. doi: 10.1016/s0264-410x(98)00204-7. PMID: 9987173. 14: Pierce NF, Sacci JB Jr. Enhanced mucosal priming by cholera toxin and procholeragenoid with a lipoidal amine adjuvant (avridine) delivered in liposomes. Infect Immun. 1984 May;44(2):469-73. doi: 10.1128/iai.44.2.469-473.1984. PMID: 6370867; PMCID: PMC263543. 15: Joe B, Wilder RL. Animal models of rheumatoid arthritis. Mol Med Today. 1999 Aug;5(8):367-9. doi: 10.1016/s1357-4310(99)01528-2. PMID: 10475714. 16: Fatunmbi OO, Newman JA, Sivanandan V, Halvorson DA. Efficacy of avridine and liposomes as adjuvants for avian influenza virus antigens in turkeys. Avian Pathol. 1992;21(2):225-37. doi: 10.1080/03079459208418838. PMID: 18670935. 17: Lorentzen JC, Klareskog L. Comparative susceptibility of DA, LEW, and LEW.1AV1 rats to arthritis induced with different arthritogens: mineral oil, mycobacteria, muramyl dipeptide, avridine and rat collagen type II. Transplant Proc. 1997 May;29(3):1692-3. doi: 10.1016/s0041-1345(97)00018-3. PMID: 9142235. 18: Anderson AO, Rubin DH. Effect of Avridine on enteric antigen uptake and mucosal immunity to reovirus (1/Lang). Adv Exp Med Biol. 1985;186:579-90. doi: 10.1007/978-1-4613-2463-8_71. PMID: 4050592. 19: Wigdorovitz A, Zamorano P, Borca MV, Sadir AM. Modulation of the antigen presentation activity in foot and mouth disease virus (FMDV) vaccines by two adjuvants: avridine and a water soluble fraction of Mycobacterium sp. Vaccine. 1998 Oct;16(17):1627-32. doi: 10.1016/s0264-410x(98)00059-0. PMID: 9713938. 20: Anderson AO, Wood OL, King AD, Stephenson EH. Studies on anti-viral mucosal immunity with the lipoidal amine adjuvant avridine. Adv Exp Med Biol. 1987;216B:1781-90. PMID: 3425462.