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MedKoo Cat#: 326638 | Name: Argipressin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Argipressin is the predominant form of mammalian antidiuretic hormone. Argipressin is a nonapeptide containing an ARGININE at residue 8 and two disulfide-linked CYSTEINES at residues of 1 and 6. Arg-vasopressin is used to treat diabetes insipidus or to improve vasomotor tone and blood pressure.

Chemical Structure

Argipressin
CAS#113-79-1 (free base)

Theoretical Analysis

MedKoo Cat#: 326638

Name: Argipressin

CAS#: 113-79-1 (free base)

Chemical Formula: C46H65N15O12S2

Exact Mass: 1083.4400

Molecular Weight: 1084.24

Elemental Analysis: C, 50.96; H, 6.04; N, 19.38; O, 17.71; S, 5.91

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 650.00 2 Weeks
50mg USD 950.00 2 Weeks
1g USD 2,950.00 2 Weeks
2g USD 5,450.00 2 Weeks
5g USD 8,650.00 2 Weeks
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Related CAS #
83968-48-3 (acetate) 113-79-1 (free base)
Synonym
Argipressin; Pitressin; Vasopressin. H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bond)
IUPAC/Chemical Name
(S)-N-((S)-1-((2-amino-2-oxoethyl)amino)-5-guanidino-1-oxopentan-2-yl)-1-((4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)pyrrolidine-2-carboxamide
InChi Key
KBZOIRJILGZLEJ-LGYYRGKSSA-N
InChi Code
InChI=1S/C46H65N15O12S2/c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53)/t27-,28-,29-,30-,31-,32-,33-,34-/m0/s1
SMILES Code
O=C([C@H]1N(C([C@@H](NC([C@H](CC(N)=O)NC([C@H](CCC(N)=O)NC([C@H](CC2=CC=CC=C2)NC([C@H](CC3=CC=C(O)C=C3)N4)=O)=O)=O)=O)CSSC[C@H](N)C4=O)=O)CCC1)N[C@@H](CCCNC(N)=N)C(NCC(N)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,084.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cohn JA, Kowalik CG, Reynolds WS, Kaufman MR, Milam DF, Dmochowski RR, Wein AJ. Desmopressin acetate nasal spray for adults with nocturia. Expert Rev Clin Pharmacol. 2017 Dec;10(12):1281-1293. doi: 10.1080/17512433.2017.1394185. Epub 2017 Oct 30. PMID: 29048257. 2: Karanth L, Barua A, Kanagasabai S, Nair S. Desmopressin acetate (DDAVP) for preventing and treating acute bleeds during pregnancy in women with congenital bleeding disorders. Cochrane Database Syst Rev. 2015 Sep 9;(9):CD009824. doi: 10.1002/14651858.CD009824.pub3. Update in: Cochrane Database Syst Rev. 2019 Feb 13;2:CD009824. PMID: 26350784. 3: Karanth L, Barua A, Kanagasabai S, Nair NS. Desmopressin acetate (DDAVP) for preventing and treating acute bleeds during pregnancy in women with congenital bleeding disorders. Cochrane Database Syst Rev. 2013 Apr 30;(4):CD009824. doi: 10.1002/14651858.CD009824.pub2. Update in: Cochrane Database Syst Rev. 2015;(9):CD009824. PMID: 23633378. 4: Alford N, Hashim H. Desmopressin acetate the first sublingual tablet to treat nocturia due to nocturnal polyuria. Expert Rev Clin Pharmacol. 2021 Aug;14(8):939-954. doi: 10.1080/17512433.2021.1931122. Epub 2021 Jun 14. PMID: 33993824. 5: Ferraris VA, Klingman R, Bufo A, Saifi J. Cardiopulmonary bypass. Curr Opin Cardiol. 1991 Apr;6(2):227-34. doi: 10.1097/00001573-199104000-00009. PMID: 10171173. 6: Hayashi M. [Pharmacological and clinical profile of desmopressin acetate hydrate (MINIRIN Melt(®))]. Nihon Yakurigaku Zasshi. 2013 Mar;141(3):169-74. Japanese. doi: 10.1254/fpj.141.169. PMID: 23470483. 7: Higasa S, Tokugawa T, Sawada A. [Diagnosis and management of von Willebrand disease]. Rinsho Ketsueki. 2018;59(10):2222-2232. Japanese. doi: 10.11406/rinketsu.59.2222. PMID: 30305529. 8: Lim CC, Tan HZ, Tan CS, Healy H, Choo J, Franca Gois PH. Desmopressin acetate to prevent bleeding in percutaneous kidney biopsy: a systematic review. Intern Med J. 2021 Apr;51(4):571-579. doi: 10.1111/imj.14774. PMID: 32040251. 9: Daugirdas JT, Nawab ZM. Acetate relaxation of isolated vascular smooth muscle. Kidney Int. 1987 Jul;32(1):39-46. doi: 10.1038/ki.1987.169. PMID: 3626298. 10: Korkmaz U, Demir E, Yazici H, Sever MS. Hypertensive pulmonary edema related to desmopressin acetate. Nefrologia. 2017 May-Jun;37(3):349-350. English, Spanish. doi: 10.1016/j.nefro.2016.11.008. PMID: 28648214. 11: Daugirdas JT, Swanson V, Islam S, Nutting C, Kim DD, Wang XA, Fiscus RR. Acetate causes endothelium-independent increases in cyclic AMP in rat caudal artery. Am J Physiol. 1988 Dec;255(6 Pt 2):H1378-83. doi: 10.1152/ajpheart.1988.255.6.H1378. PMID: 2462365. 12: McManus J, Ferreira J, Jones GM, Smetana KS, Smith Condeni M, Berger K, Witenko C, Smotherman C, Gautam S, Pizzi MA, Erdman MJ. Effect of desmopressin acetate on acute spontaneous intracranial hemorrhage in patients on antiplatelet therapy. J Neurol Sci. 2022 Mar 15;434:120142. doi: 10.1016/j.jns.2022.120142. Epub 2022 Jan 6. PMID: 35081458. 13: Zachoval R, Krhut J, Šottner O, Hanuš T, Martan A, Horčička L, Feyereisl J, Halaška M, Švabík K, Krofta L. Léčba noční polyurie desmopresinem [Nocturnal polyuria, treatment with desmopressin]. Ceska Gynekol. 2013 Aug;78(4):385-9. Czech. PMID: 24040989. 14: Steele BT. Nocturnal enuresis. Treatment options. Can Fam Physician. 1993 Apr;39:877-80. PMID: 8495145; PMCID: PMC2379840. 15: Vance DA. Desmopressin acetate. J Post Anesth Nurs. 1988 Feb;3(1):65-6. PMID: 3351781. 16: Bloom DA. The American experience with desmopressin. Clin Pediatr (Phila). 1993 Jul;Spec No:28-31. doi: 10.1177/0009922893032001s07. PMID: 8039336. 17: Karanth L, Barua A, Kanagasabai S, Nair NS. Desmopressin acetate (DDAVP) for preventing and treating acute bleeds during pregnancy in women with congenital bleeding disorders. Cochrane Database Syst Rev. 2019 Feb 13;2(2):CD009824. doi: 10.1002/14651858.CD009824.pub4. PMID: 30758840; PMCID: PMC6373982. 18: Qiao LY, Du YC. Involvement of a putative G-protein-coupled receptor and a branching pathway in argipressin (4-8) signal transduction in rat hippocampus. Zhongguo Yao Li Xue Bao. 1998 Jan;19(1):15-20. PMID: 10375750. 19: Moffatt ME, Harlos S, Kirshen AJ, Burd L. Desmopressin acetate and nocturnal enuresis: how much do we know? Pediatrics. 1993 Sep;92(3):420-5. PMID: 8361796. 20: Mansouritorghabeh H, Shirdel A. Desmopressin acetate as a haemostatic elevator in individuals with combined deficiency of factors V and VIII: a clinical trial. J Thromb Haemost. 2016 Feb;14(2):336-9. doi: 10.1111/jth.13207. Epub 2016 Jan 30. PMID: 26599105.