AS-1669058 oxalate | CAS#1395553-32-8 | 1395553-31-7 | GPR119 Agonist

MedKoo Cat#: 524267 | Name: AS-1669058 oxalate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AS-1669058 is a G-protein-coupled receptor 119 (GPR119) agonist used to as new drug to treat type 2 diabetes.

Chemical Structure

AS-1669058 oxalate

CAS#1395553-32-8 (oxalate)

Theoretical Analysis

MedKoo Cat#: 524267

Name: AS-1669058 oxalate

CAS#: 1395553-32-8 (oxalate)

Chemical Formula: C20H17BrF2N4O5

Exact Mass:

Molecular Weight: 511.27

Elemental Analysis: C, 46.98; H, 3.35; Br, 15.63; F, 7.43; N, 10.96; O, 15.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

1395553-32-8 (oxalate) 1395553-31-7 (free base)

Synonym

AS-1669058; AS 1669058; AS1669058; AS-1669058 oxalate

IUPAC/Chemical Name

3-(2-((2-(4-bromo-2,5-difluorophenyl)-6-methylpyrimidin-4-yl)amino)ethyl)pyridine 1-oxide oxalate

InChi Key

RHZMWZFMDCGRBP-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H15BrF2N4O.C2H2O4/c1-11-7-17(22-5-4-12-3-2-6-25(26)10-12)24-18(23-11)13-8-16(21)14(19)9-15(13)20;3-1(4)2(5)6/h2-3,6-10H,4-5H2,1H3,(H,22,23,24);(H,3,4)(H,5,6)

SMILES Code

Cc1cc(nc(n1)c2cc(c(cc2F)Br)F)NCCc3ccc[n+](c3)[O-].C(=O)(C(=O)O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Related: 1395553-32-8 (AS-1669058) 1395553-31-7 (AS-1669058 free base)

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 511.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Oshima H, Yoshida S, Ohishi T, Matsui T, Tanaka H, Yonetoku Y, Shibasaki M, Uchiyama Y. Novel GPR119 agonist AS1669058 potentiates insulin secretion from rat islets and has potent anti-diabetic effects in ICR and diabetic db/db mice. Life Sci. 2013 Feb 7;92(2):167-73. doi: 10.1016/j.lfs.2012.11.015. Epub 2012 Dec 13. PubMed PMID: 23246743.