MedKoo Cat#: 526620 | Name: TB-21007
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TB-21007 is a nootropic drug which acts as a subtype-selective inverse agonist at the α5 containing GABAA receptors. TB-21007 impaired rats' memory of the initial shock-probe experience when infused into the dorsal hippocampus, but not when infused into the ventral hippocampus.

Chemical Structure

TB-21007
TB-21007
CAS#207306-50-1

Theoretical Analysis

MedKoo Cat#: 526620

Name: TB-21007

CAS#: 207306-50-1

Chemical Formula: C15H17NO2S3

Exact Mass: 339.0421

Molecular Weight: 339.49

Elemental Analysis: C, 53.07; H, 5.05; N, 4.13; O, 9.43; S, 28.33

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 500.00 2 Weeks
25mg USD 850.00 2 Weeks
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Related CAS #
No Data
Synonym
TB-21007, TB 21007, TB21007
IUPAC/Chemical Name
6,6-dimethyl-3-(2-hydroxyethyl)thio-1-(thiazol-2-yl)-6,7-dihydro-2-benzothiophen-4(5H)-one
InChi Key
QILRYFCEXLFIDS-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H17NO2S3/c1-15(2)7-9-11(10(18)8-15)14(20-6-4-17)21-12(9)13-16-3-5-19-13/h3,5,17H,4,6-8H2,1-2H3
SMILES Code
O=C1CC(C)(C)CC2=C(C3=NC=CS3)SC(SCCO)=C21
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 339.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: McEown K, Treit D. Α2 GABAA receptor sub-units in the ventral hippocampus and α5 GABAA receptor sub-units in the dorsal hippocampus mediate anxiety and fear memory. Neuroscience. 2013 Nov 12;252:169-77. doi: 10.1016/j.neuroscience.2013.08.012. Epub 2013 Aug 17. PubMed PMID: 23962649. 2: Chen X, Keramidas A, Lynch JW. Physiological and pharmacological properties of inhibitory postsynaptic currents mediated by α5β1γ2, α5β2γ2 and α5β3γ2 GABAA receptors. Neuropharmacology. 2017 Oct;125:243-253. doi: 10.1016/j.neuropharm.2017.07.027. Epub 2017 Jul 27. PMID: 28757051.