Cudetaxestat is a non-competitive autotaxin inhibitor under investigation for its potential in treating fibrotic diseases. In vitro studies have demonstrated that cudetaxestat effectively inhibits autotaxin enzymatic activity with nanomolar potency, reducing the production of lysophosphatidic acid (LPA), a key mediator of fibrosis and inflammation. Compared to earlier autotaxin inhibitors, cudetaxestat exhibits a prolonged inhibitory effect due to its covalent binding mechanism. Cellular assays further confirm its ability to suppress LPA-driven signaling pathways, leading to reduced fibroblast proliferation and extracellular matrix deposition. These findings suggest cudetaxestat as a promising antifibrotic agent with superior pharmacological properties.
MedKoo Cat#: 577737
Name: Cudetaxestat
CAS#: 1782070-21-6 (free base)
Chemical Formula: C21H15Cl2F2N3O2S
Exact Mass: 481.0230
Molecular Weight: 482.33
Elemental Analysis: C, 52.29; H, 3.13; Cl, 14.70; F, 7.88; N, 8.71; O, 6.63; S, 6.65
The following data is based on the product molecular weight 482.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
