GYKI-16638 HCl | CAS#307556-59-8 | 778564-77-5 | antiarrhythmic

MedKoo Cat#: 526611 | Name: GYKI-16638 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GYKI-16638 is a novel antiarrhythmic agent. GYKI-16638 has an in vivo antiarrhythmic effect, comparable to that of D-sotalol. GYKI 16638 in human ventricular muscle shows combined Class IB and Class III antiarrhythmic properties, resembling the electrophysiological manifestation seen after chronic amiodarone treatment.

Chemical Structure

GYKI-16638 HCl

CAS#307556-59-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 526611

Name: GYKI-16638 HCl

CAS#: 307556-59-8 (HCl)

Chemical Formula: C21H31ClN2O5S

Exact Mass:

Molecular Weight: 459.00

Elemental Analysis: C, 54.95; H, 6.81; Cl, 7.72; N, 6.10; O, 17.43; S, 6.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

307556-59-8 (HCl) 778564-77-5 (free base)

Synonym

GYKI-16638; GYKI 16638; GYKI16638; GYKI-16,638; GYKI 16,638; GYKI16,638.

IUPAC/Chemical Name

N-(4-(2-((1-(2,6-dimethoxyphenoxy)propan-2-yl)(methyl)amino)ethyl)phenyl)methanesulfonamide hydrochloride

InChi Key

DEVXAIVAHHEHKR-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H30N2O5S.ClH/c1-16(15-28-21-19(26-3)7-6-8-20(21)27-4)23(2)14-13-17-9-11-18(12-10-17)22-29(5,24)25;/h6-12,16,22H,13-15H2,1-5H3;1H

SMILES Code

CS(=O)(NC1=CC=C(CCN(C(C)COC2=C(OC)C=CC=C2OC)C)C=C1)=O.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 459.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mátyus P, Varga I, Rettegi T, Simay A, Kállay N, Károlyházy L, Kocsis A, Varró A, Pénzes I, Papp JG. Novel antiarrhythmic compounds with combined class IB and class III mode of action. Curr Med Chem. 2004 Jan;11(1):61-9. Review. PubMed PMID: 14754426. 2: Opincariu M, Varró A, Iost N, Virág L, Hála O, Szolnoki J, Szécsi J, Bogáts G, Szenohradszky P, Mátyus P, Papp JG. The cellular electrophysiologic effect of a new amiodarone like antiarrhythmic drug GYKI 16638 in undiseased human ventricular muscle: comparison with sotalol and mexiletine. Curr Med Chem. 2002 Jan;9(1):41-6. PubMed PMID: 11860346. 3: Baczkó I, El-Reyani NE, Farkas A, Virág L, Iost N, Leprán I, Mátyus P, Varró A, Papp JG. Antiarrhythmic and electrophysiological effects of GYKI-16638, a novel N-(phenoxyalkyl)-N-phenylalkylamine, in rabbits. Eur J Pharmacol. 2000 Sep 15;404(1-2):181-90. PubMed PMID: 10980278.