GYKI-16084 is a postsynaptic alpha2-blocker. GYKI-16084 may be potentially useful for the treatment of benign prostatic hyperplasia. The combined alpha1- and postsynaptically selective alpha2-blocker GYKI-16084 significantly improved the AUA symptom scores and increased Q(max) in patients with BPH, without inducing any adverse reaction, orthostatic changes or erectile dysfunction.
MedKoo Cat#: 526609
Name: GYKI-16084
CAS#: 185739-21-3 (free base)
Chemical Formula: C16H19N3O3
Exact Mass: 301.1426
Molecular Weight: 301.35
Elemental Analysis: C, 63.77; H, 6.36; N, 13.94; O, 15.93
The following data is based on the product molecular weight 301.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
