GYKI-13324 | CAS#76123-41-6

MedKoo Cat#: 206627 | Name: GYKI-13324

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GYKI-13324 is bifunctional nitrosoureido derivative and alkylating agent. GYKI-13324 was studied on human colorectal tumor xenograft lines. Given orally in single or multiple daily doses, GYKI-13324 produced long-term or total regression of adenomatous, but only marginal growth delay of mucinous tumors. GYKI-13324, with slightly lower toxicity than that of BCNU, seems to be a candidate in the clinical management of colorectal tumors.

Chemical Structure

GYKI-13324

CAS#76123-41-6

Theoretical Analysis

MedKoo Cat#: 206627

Name: GYKI-13324

CAS#: 76123-41-6

Chemical Formula: C10H18Cl2N6O6

Exact Mass: 388.0665

Molecular Weight: 389.19

Elemental Analysis: C, 30.86; H, 4.66; Cl, 18.22; N, 21.59; O, 24.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

GYKI-13324; GYKI 13324; GYKI13324.

IUPAC/Chemical Name

N-(2-Chloroethyl)-N'-(4-((((2-chloroethyl)amino)carbonyl)nitrosamino)-2,3-dihydroxybutyl)-N-nitrosourea

InChi Key

UYXBAEBEXLEPKR-UHFFFAOYSA-N

InChi Code

InChI=1S/C10H18Cl2N6O6/c11-1-3-13-9(21)18(16-24)6-8(20)7(19)5-14-10(22)17(15-23)4-2-12/h7-8,19-20H,1-6H2,(H,13,21)(H,14,22)

SMILES Code

O=C(NCC(O)C(O)CN(C(NCCCl)=O)N=O)N(CCCl)N=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 389.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Pál K, Kopper L, Lapis K. Chemotherapeutic sensitivity of liver metastases from intrasplenically-growing Lewis lung tumor. Clin Exp Metastasis. 1983 Oct-Dec;1(4):341-7. PubMed PMID: 6443744. 2: Kopper L, Lapis K, Csányi E, Horváth T. Effect of a new bifunctional nitrosoureido derivative on human colorectal tumor xenografts. Anticancer Res. 1981;1(4):229-33. PubMed PMID: 7345967. 3: Csányi E, Horváth T, Király E, Lapis K, Kopper L. New type bifunctional nitrosoureido derivatives with cytostatic activity. Oncology. 1980;37 Suppl 1:59-66. PubMed PMID: 7454201.