GW1100 | CAS#306974-70-9 | antagonist of GPR40

MedKoo Cat#: 526772 | Name: GW1100

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GW1100 is a a selective antagonist of GPR40.

Chemical Structure

GW1100

CAS#306974-70-9

Theoretical Analysis

MedKoo Cat#: 526772

Name: GW1100

CAS#: 306974-70-9

Chemical Formula: C27H25FN4O4S

Exact Mass: 520.1581

Molecular Weight: 520.58

Elemental Analysis: C, 62.30; H, 4.84; F, 3.65; N, 10.76; O, 12.29; S, 6.16

Price and Availability

Size	Price	Availability
10mg	USD 350.00	2 Weeks
25mg	USD 650.00	2 Weeks
50mg	USD 950.00	2 Weeks

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Related CAS #

No Data

Synonym

GW 1100; GW-1100; GW1100.

IUPAC/Chemical Name

ethyl 4-(5-((2-ethoxypyrimidin-5-yl)methyl)-2-((4-fluorobenzyl)thio)-4-oxopyrimidin-1(4H)-yl)benzoate

InChi Key

PTPNCCWOTBBVJR-UHFFFAOYSA-N

InChi Code

InChI=1S/C27H25FN4O4S/c1-3-35-25(34)20-7-11-23(12-8-20)32-16-21(13-19-14-29-26(30-15-19)36-4-2)24(33)31-27(32)37-17-18-5-9-22(28)10-6-18/h5-12,14-16H,3-4,13,17H2,1-2H3

SMILES Code

FC1=CC=C(CSC(N(C2=CC=C(C(OCC)=O)C=C2)C=C3CC4=CN=C(OCC)N=C4)=NC3=O)C=C1

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 520.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Involvement of GPR40, a long-chain free fatty acid receptor, in the production of central post-stroke pain after global cerebral ischemia. Eur J Pharmacol. 2014 Dec 5;744:115-23. doi: 10.1016/j.ejphar.2014.09.036. Epub 2014 Sep 30. PubMed PMID: 25281202. 13: Zamarbide M, Etayo-Labiano I, Ricobaraza A, Martínez-Pinilla E, Aymerich MS, Luis Lanciego J, Pérez-Mediavilla A, Franco R. GPR40 activation leads to CREB and ERK phosphorylation in primary cultures of neurons from the mouse CNS and in human neuroblastoma cells. Hippocampus. 2014 Jul;24(7):733-9. doi: 10.1002/hipo.22263. Epub 2014 Feb 27. PubMed PMID: 24550142. 14: Nakamoto K, Nishinaka T, Sato N, Mankura M, Koyama Y, Kasuya F, Tokuyama S. Hypothalamic GPR40 signaling activated by free long chain fatty acids suppresses CFA-induced inflammatory chronic pain. PLoS One. 2013 Dec 12;8(12):e81563. doi: 10.1371/journal.pone.0081563. eCollection 2013. 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