Tobanum | Cloranolol HCl | CAS# 54247-25-5

MedKoo Cat#: 522538 | Name: Tobanum HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tobanum, also known as Cloranolol and GYKI-41099, is a long-acting beta-blocker. Clinical trials report showed that Tobanum produced antianginal effect in 82.2% of cases, and was well tolerated. The effect of one 5 mg pill set on later, as compared to anaprilin, and lasted longer (averaging 12 hours). Chloranolol treatment was particularly efficient in moderately hypertensive patients and also in some highly-hypertensive ones that had not responded to propranolol.

Chemical Structure

Tobanum HCl

CAS# 54247-25-5 (HCl)

Theoretical Analysis

MedKoo Cat#: 522538

Name: Tobanum HCl

CAS#: 54247-25-5 (HCl)

Chemical Formula: C13H20Cl3NO2

Exact Mass: 327.0560

Molecular Weight: 328.66

Elemental Analysis: C, 47.51; H, 6.13; Cl, 32.36; N, 4.26; O, 9.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

39563-28-5 (free base) 54247-25-5 (HCl)

Synonym

GYKI-41099; GYKI 41099; GYKI41099; Tobanum; Cloranolol HCl.

IUPAC/Chemical Name

1-(2,5-Dichlorophenoxy)-3-(tert-butylamino)-2-propanol hydrochloride

InChi Key

GSMITOPOWVFGOM-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H19Cl2NO2.ClH/c1-13(2,3)16-7-10(17)8-18-12-6-9(14)4-5-11(12)15;/h4-6,10,16-17H,7-8H2,1-3H3;1H

SMILES Code

OC(CNC(C)(C)C)COC1=CC(Cl)=CC=C1Cl.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 328.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mátyus P. [Cardiovascular system research at the Institute of Drug Research]. Acta Pharm Hung. 2001;71(1):67-72. Hungarian. PubMed PMID: 11769098. 2: Syrenskiĭ AV, Tsyrlin VA. [The effect of beta-adrenoblockaders on the elasticity of the vessels of the greater circulation]. Eksp Klin Farmakol. 1995 May-Jun;58(3):23-4. Russian. PubMed PMID: 7663288. 3: Ivanov SG. [The comparative efficacy of nondrug and drug methods of treating hypertension]. Ter Arkh. 1993;65(1):44-9. Russian. PubMed PMID: 8036572. 4: Grosu AA, Zhosan SI. [Effectiveness and pharmacodynamics of tobanum in patients with paroxysmal reciprocal atrioventricular tachycardia]. Kardiologiia. 1991 Jul;31(7):45-7. Russian. PubMed PMID: 1685755. 5: Ivanov SG, Smirnov VV, Batorina MI, Pastushenko LS. [The hemodynamic effects of a number of new hypotensive preparations]. Ter Arkh. 1990;62(1):29-32. Russian. PubMed PMID: 2333612. 6: Kempler P, Jóna G, Somogyi A, Varsányi-Nagy M, Rohla M, Balázsi L. Late effect of tobanum and tobanum + furosemide therapy on the glucose tolerance of patients and on the insulin response to oral glucose doses. Ther Hung. 1990;38(1):22-5. PubMed PMID: 1971732. 7: Kulcsár-Gergely J. Action of beta-adrenoceptor blockers on liver function of rats. Arzneimittelforschung. 1989 Jul;39(7):782-5. PubMed PMID: 2571334. 8: Shliakhto EV, Savushkin SN, Bondarenko BB. [Hypotensive effect of tobanum in hypertension]. Sov Med. 1989;(10):65-7. Russian. PubMed PMID: 2694384. 9: Korkushko OV, Shatilo VB, Butenko AG. [Effectiveness of tobanum and visken in ischemic heart disease with extrasystole]. Sov Med. 1989;(12):66-8. Russian. PubMed PMID: 2483591. 10: Maziĭ SA, Senik EA, Turashvili GA, Zisel'man SB, Kazarian AB. [Use of beta adrenergic receptor blockaders in industrial workers with neurocirculatory asthenia of the hypertensive type]. Sov Med. 1988;(7):96-9. Russian. PubMed PMID: 3067385. 11: Sirakova V, Penkov N, Kaponov Kh. [Relaxation and rapid filling of the left ventricle in essential hypertension during treatment with a non-selective beta blocker]. Vutr Boles. 1987;26(3):33-8. Bulgarian. PubMed PMID: 2887071. 12: Charyev KhE, Erina EV, Ibraimova AS, Prokopova TN, Iurenev AP. [Clinical use of chloranolol (tobanum) in essential hypertension patients]. Kardiologiia. 1986 Dec;26(12):86-9. Russian. PubMed PMID: 3560618. 13: Ol'binskaia LI, Vartanova OA. [Clinical and cardiohemodynamic effects of the new long-acting beta-blocker tobanum]. Kardiologiia. 1986 Feb;26(2):48-51. Russian. PubMed PMID: 2422430. 14: Udvarhelyi A. Tobanum treatment in mild and medium severity hypertension. Ther Hung. 1986;34(3):171-4. PubMed PMID: 2894722. 15: Sirakova V, Penkov N, Kaponov Kh. [Clinical study of the beta-blocker chlorpropanol (tobanum) in hypertension patients]. Vutr Boles. 1986;25(1):35-41. Bulgarian. PubMed PMID: 2872751. 16: Török E, Kósa E, Szontagh M, Juvancz P, Eggenhofer J, Borvendég J. Incidence of side effects during the application of placebo and active therapy (Tobanum) in patients suffering from hypertension, angina pectoris and arrhythmia. Int J Clin Pharmacol Ther Toxicol. 1985 Dec;23(12):650-6. PubMed PMID: 2868999. 17: Gambashidze NB, Kobaladze SG, Burdiashvili BSh, Kikodze NL, Mamaladze GT. [Effect of tobanum on various functions of the heart in patients with ischemic heart disease and prospects for its clinical application]. Kardiologiia. 1985 Sep;25(9):77-9. Russian. PubMed PMID: 2867245. 18: Sipos Z, Hollósi Z, Iskum M. Clinical examination of the beta-adrenergic receptor blocking activity of Tobanum in spontaneously occurring anginas. Ther Hung. 1984;32(2):74-8. PubMed PMID: 6152819. 19: Török E, Kósa E, Szontagh M, Juvancz P, Eggenhofer J, Borvendég J. Comparison of methods to detect side-effect on clinical application of chloranolol, a beta-adrenergic receptor inhibitor. Eur J Clin Pharmacol. 1984;26(5):555-62. PubMed PMID: 6147256. 20: Hankóczy J, Török E, Békés M, Podmaniczky M, Cheh K. Long-term use of tobanum in arrhythmias. Ther Hung. 1984;32(1):16-8. PubMed PMID: 6085943.