GYKI-53784, also known as LY 303070, is a potent and selective AMPA receptor antagonist. GYKI 53784 blocks action potential generation and excitotoxicity in the guinea pig cochlea. GYKI 53784 had the same potency as DNQX and was 10 times more potent than GYKI 52466 in reducing auditory nerve activity. GYKI 53784 completely blocked excitotoxicity (i.e. destruction of the afferent nerve endings) induced by AMPA and kainate. The histochemical detection of Co(2+) uptake was used to study Ca(2+) influx within the primary auditory nerve cells.
MedKoo Cat#: 522534
Name: GYKI-53784
CAS#: 161832-71-9
Chemical Formula: C19H20N4O3
Exact Mass: 352.1535
Molecular Weight: 352.39
Elemental Analysis: C, 64.76; H, 5.72; N, 15.90; O, 13.62
The following data is based on the product molecular weight 352.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
