GW590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ. GW590735 significantly increased HDL cholesterol, decreased LDL and VLDL cholesterol, and significantly reduced triglycerides. Maximal increases in HDL cholesterol were 37%, 53%, and 84% with fenofibrate, torcetrapib, and GW590735, respectively.
MedKoo Cat#: 522711
Name: GW590735
CAS#: 343321-96-0 (free acid)
Chemical Formula: C23H21F3N2O4S
Exact Mass: 478.1174
Molecular Weight: 478.49
Elemental Analysis: C, 57.73; H, 4.42; F, 11.91; N, 5.85; O, 13.37; S, 6.70
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 30.0 | 62.70 | |
| DMSO | 30.0 | 62.70 | |
| Ethanol | 30.0 | 62.70 | |
| PBS (pH 7.2) | 0.3 | 0.52 |
The following data is based on the product molecular weight 478.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
