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MedKoo Cat#: 318583 | Name: Propafenone Hydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Propafenone Hydrochloride is a sodium channel protein inhibitor. Propafenone Hydrochloride is an inhibitor of AR.

Chemical Structure

Propafenone Hydrochloride
Propafenone Hydrochloride
CAS#34183-22-7

Theoretical Analysis

MedKoo Cat#: 318583

Name: Propafenone Hydrochloride

CAS#: 34183-22-7

Chemical Formula: C21H28ClNO3

Exact Mass: 0.0000

Molecular Weight: 377.90

Elemental Analysis: C, 66.74; H, 7.47; Cl, 9.38; N, 3.71; O, 12.70

Price and Availability

Size Price Availability Quantity
25mg USD 150.00
50mg USD 250.00
100mg USD 350.00
200mg USD 450.00
500mg USD 550.00
1g USD 650.00
2g USD 850.00
5g USD 1,250.00
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Synonym
Propafenone Hydrochloride; Propafenone HCl; Rytmonorm; Pronon; Arythmol; Abbott Brand of Propafenone Hydrochloride; Aliud Brand of Propafenone Hydrochloride; Alpharma Brand of Propafenone Hydrochloride; Baxarytmon; Cuxafenon; Fenoprain;
IUPAC/Chemical Name
1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one;hydrochloride
InChi Key
XWIHRGFIPXWGEF-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H
SMILES Code
CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 377.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Uekusa T, Sugano K. Prediction of Liquid-Liquid Phase Separation at the Dissolving Drug Salt Particle Surface. Mol Pharm. 2023 Jun 5;20(6):3140-3149. doi: 10.1021/acs.molpharmaceut.3c00157. Epub 2023 May 14. PMID: 37183369. 2: Lin YS, Lin SC, Hsieh YT, Liu LY, Lin CH, Shen LJ, Huang CF. Formulation and stability of an extemporaneously compounded propafenone hydrochloride oral suspension for children with arrhythmia. Eur J Hosp Pharm. 2022 Nov;29(6):324-328. doi: 10.1136/ejhpharm-2020-002567. Epub 2021 Feb 19. PMID: 33608396; PMCID: PMC9614132. 3: Liu M, Li Y, Tang Y, Zheng L, Peng C. Synergistic effect of Aconiti Lateralis Radix Praeparata water-soluble alkaloids and Ginseng Radix et Rhizoma total ginsenosides compatibility on acute heart failure rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2020 Jan 15;1137:121935. doi: 10.1016/j.jchromb.2019.121935. Epub 2019 Dec 9. PMID: 31877430. 4: Chen S, Ding W, Ye J, Wang Z, Zhao X, Cui Y. Propafenone-associated Gross Hematuria: A Case Report and Review of the Literature. Clin Ther. 2019 Aug;41(8):1614-1620. doi: 10.1016/j.clinthera.2019.05.002. Epub 2019 Jun 1. PMID: 31164244. 5: Wang QH, Gao JH, Chen HM, Xie XF, Peng C. [Transcriptomics study on mechanism of Aconiti Lateralis Radix Praeparata in treatment of rats with acute heart failure]. Zhongguo Zhong Yao Za Zhi. 2019 Jan;44(1):131-140. Chinese. doi: 10.19540/j.cnki.cjcmm.20180903.004. PMID: 30868824. 6: He YN, Zhang DK, Lin JZ, Han X, Zhang YM, Zhang HZ, Pei J, Yang M, Wang JB. Cardiac function evaluation for a novel one-step detoxification product of Aconiti Lateralis Radix Praeparata. Chin Med. 2018 Dec 17;13:62. doi: 10.1186/s13020-018-0219-4. PMID: 30568725; PMCID: PMC6297959. 7: Baxevanis F, Kuiper J, Fotaki N. Impact of presence of excipients in drug analysis in fed-state gastric biorelevant media. Eur J Pharm Biopharm. 2018 Oct;131:178-188. doi: 10.1016/j.ejpb.2018.08.004. Epub 2018 Aug 12. PMID: 30110669. 8: Zhang L, Lu X, Wang J, Li P, Li H, Wei S, Zhou X, Li K, Wang L, Wang R, Zhao Y, Xiao X. Zingiberis rhizoma mediated enhancement of the pharmacological effect of aconiti lateralis radix praeparata against acute heart failure and the underlying biological mechanisms. Biomed Pharmacother. 2017 Dec;96:246-255. doi: 10.1016/j.biopha.2017.09.145. Epub 2017 Oct 6. PMID: 28987949. 9: Li Y, Wang LX, Xie YM. [Efficacy and safety of smiltiorrhizadepsidesal combined with conventional western medicine treatment for stable angina pectoris]. Zhongguo Zhong Yao Za Zhi. 2016 Dec;41(24):4488-4493. Chinese. doi: 10.4268/cjcmm20162403. PMID: 28936828. 10: Lu X, Zhang L, Li P, Wang J, Li R, Huang Y, Wu M, Zhou H, Li Y, Wei S, Li K, Li H, Zhou X, Zhao Y, Xiao X. The protective effects of compatibility of Aconiti Lateralis Radix Praeparata and Zingiberis Rhizoma on rats with heart failure by enhancing mitochondrial biogenesis via Sirt1/PGC-1α pathway. Biomed Pharmacother. 2017 Aug;92:651-660. doi: 10.1016/j.biopha.2017.05.117. Epub 2017 Jun 2. PMID: 28578259. 11: Pan L, Qian Y, Cheng M, Gu P, He Y, Xu X, Ding L. Pharmacokinetics of propafenone hydrochloride sustained-release capsules in male beagle dogs. Acta Pharm Sin B. 2015 Jan;5(1):74-8. doi: 10.1016/j.apsb.2014.11.003. Epub 2015 Jan 7. PMID: 26579428; PMCID: PMC4629124. 12: Zhang L, Jiang P, Liu J. Novel sustained-release of propafenone through pellets: preparation and in vitro/in vivo evaluation. Int J Mol Sci. 2014 Sep 2;15(9):15503-11. doi: 10.3390/ijms150915503. PMID: 25184949; PMCID: PMC4200845. 13: Siva S, Thulasidhasan J, Rajendiran N. Host-guest inclusion complex of propafenone hydrochloride with α- and β-cyclodextrins: spectral and molecular modeling studies. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Nov;115:559-67. doi: 10.1016/j.saa.2013.06.079. Epub 2013 Jun 29. PMID: 23872014. 14: Ito N, Tashiro T, Morishige N, Nishimi M, Hayashida Y, Takeuchi K, Minematsu N, Kuwahara G, Sukehiro Y. Efficacy of propafenone hydrochloride in preventing postoperative atrial fibrillation after coronary artery bypass grafting. Heart Surg Forum. 2010 Aug;13(4):E223-7. doi: 10.1532/HSF98.20091173. PMID: 20719723. 15: D'Orazio JL, Curtis JA. Overdose of propafenone surreptitiously sold as "Percocet". J Emerg Med. 2011 Aug;41(2):172-5. doi: 10.1016/j.jemermed.2009.10.030. Epub 2010 Apr 24. PMID: 20456902. 16: Hu X, Xu D, Liu S, Liu Z, Liu S. Determination of propafenone hydrochloride by flow-injection analysis coupled with resonance light scattering detection. Luminescence. 2009 Mar-Apr;24(2):79-83. doi: 10.1002/bio.1068. PMID: 18780414. 17: Segale L, Albertini B, Giovannelli L, Pattarino F. Empirical kinetic model of propafenone release from Hot Air Coating microparticles. Int J Pharm. 2008 Apr 2;353(1-2):124-30. doi: 10.1016/j.ijpharm.2007.11.022. Epub 2007 Nov 21. PMID: 18162344. 18: Albertini B, Passerini N, Pattarino F, Rodriguez L. New spray congealing atomizer for the microencapsulation of highly concentrated solid and liquid substances. Eur J Pharm Biopharm. 2008 May;69(1):348-57. doi: 10.1016/j.ejpb.2007.09.011. Epub 2007 Oct 24. PMID: 17962005. 19: El Dawya MA, Mabrouk MM, El Barbary RA. Spectrofluorimetric determination of drugs containing active methylene group using N1-methyl nicotinamide chloride as a fluorigenic agent. Chem Pharm Bull (Tokyo). 2006 Jul;54(7):1026-9. doi: 10.1248/cpb.54.1026. PMID: 16819224. 20: Lafuente-Lafuente C, Mouly S, Longás-Tejero MA, Mahé I, Bergmann JF. Antiarrhythmic drugs for maintaining sinus rhythm after cardioversion of atrial fibrillation: a systematic review of randomized controlled trials. Arch Intern Med. 2006 Apr 10;166(7):719-28. doi: 10.1001/archinte.166.7.719. PMID: 16606807.

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