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MedKoo Cat#: 526162 | Name: Ro 19-1400

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro 19-1400 is a platelet-activating factor antagonist that directly inhibits immunoglobulin E-dependent mediator release.

Chemical Structure

Ro 19-1400
Ro 19-1400
CAS#122937-55-7

Theoretical Analysis

MedKoo Cat#: 526162

Name: Ro 19-1400

CAS#: 122937-55-7

Chemical Formula: C31H56N2O8S

Exact Mass: 616.3757

Molecular Weight: 616.86

Elemental Analysis: C, 60.36; H, 9.15; N, 4.54; O, 20.75; S, 5.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ro 19-1400; Ro19-1400; Ro-19-1400.
IUPAC/Chemical Name
3-(4-(2-((Methoxycarbonyl)oxy)-3-(((octadecylamino)carbonyl)oxy)propoxy)-4-oxobutyl)-, hydroxide, (R)-thiazolium
InChi Key
VTMUVAONYKPTSA-LNLSOMNWSA-N
InChi Code
InChI=1S/C31H54N2O7S.H2O/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-21-32-30(35)39-26-28(40-31(36)37-2)25-38-29(34)20-19-22-33-23-24-41-27-33;/h23-24,27-28H,3-22,25-26H2,1-2H3;1H2/t28-;/m1./s1
SMILES Code
O=C(OC[C@@H](OC(OC)=O)COC(NCCCCCCCCCCCCCCCCCC)=O)CCC[N+]1=CSC=C1.[OH-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 616.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gilfillan AM, Wiggan GA, Hope WC, Patel BJ, Welton AF. Ro 19-3704 directly inhibits immunoglobulin E-dependent mediator release by a mechanism independent of its platelet-activating factor antagonist properties. Eur J Pharmacol. 1990 Feb 13;176(3):255-62. PubMed PMID: 1691711. 2: Pretolani M, Lefort J, Vargaftig BB. Limited interference of specific Paf antagonists with hyper-responsiveness to Paf itself of lungs from actively sensitized guinea-pigs. Br J Pharmacol. 1989 Jun;97(2):433-42. PubMed PMID: 2474345; PubMed Central PMCID: PMC1854509.