Dimethylenastron is an inhibitor of mitotic motor kinesin Eg5 (IC50 = 200 nM). Dimethylenastron suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5. The inhibition of kinesin Eg5 by small molecules such as monastrol is currently evaluated as an approach to develop a novel class of antiproliferative drugs for the treatment of malignant tumours.
MedKoo Cat#: 407308
Name: Dimethylenastron
CAS#: 863774-58-7
Chemical Formula: C16H18N2O2S
Exact Mass: 302.1089
Molecular Weight: 302.39
Elemental Analysis: C, 63.55; H, 6.00; N, 9.26; O, 10.58; S, 10.60
| Solvent | mg/mL | mM | comments | |
|---|---|---|---|---|
| Solubility | ||||
| DMF | 10.0 | 33.07 | ||
| DMSO | 31.8 | 104.99 | ||
| Ethanol | 5.9 | 19.42 |
The following data is based on the product molecular weight 302.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
