MedKoo Cat#: 522695 | Name: BMS-986120
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

BMS-986120 is a potent and selective oral antagonist of protease-activated receptor-4 (PAR4), a thrombin-activated platelet receptor thought to be important in thrombus propagation and pathological vascular occlusion. PAR4 antagonism has potential therapeutic utility in the treatment and prevention of thrombotic diseases.

Chemical Structure

BMS-986120
BMS-986120
CAS#1478712-37-6

Theoretical Analysis

MedKoo Cat#: 522695

Name: BMS-986120

CAS#: 1478712-37-6

Chemical Formula: C23H23N5O5S2

Exact Mass: 513.1141

Molecular Weight: 513.59

Elemental Analysis: C, 53.79; H, 4.51; N, 13.64; O, 15.58; S, 12.48

Price and Availability

Size Price Availability Quantity
2mg USD 165.00 Ready to ship
5mg USD 350.00 Ready to ship
10mg USD 550.00 Ready to ship
25mg USD 1,150.00 Ready to ship
50mg USD 2,050.00 Ready to ship
100mg USD 3,650.00 Ready to ship
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Related CAS #
No Data
Synonym
BMS-986120; BMS 986120; BMS986120.
IUPAC/Chemical Name
4-(4-(((6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-4-yl)oxy)methyl)-5-methylthiazol-2-yl)morpholine
InChi Key
MINMDCMSHDBHKG-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H23N5O5S2/c1-13-17(25-21(34-13)27-4-6-31-7-5-27)12-32-18-8-14(29-2)9-19-15(18)10-20(33-19)16-11-28-22(24-16)35-23(26-28)30-3/h8-11H,4-7,12H2,1-3H3
SMILES Code
COC1=NN2C(S1)=NC(C(O3)=CC4=C3C=C(OC)C=C4OCC(N=C5N6CCOCC6)=C(S5)C)=C2
Appearance
White to off-white solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in chloroform, not soluble in DMSO, not soluble in water.
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 513.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wong PC, Seiffert D, Bird JE, Watson CA, Bostwick JS, Giancarli M, Allegretto N, Hua J, Harden D, Guay J, Callejo M, Miller MM, Lawrence RM, Banville J, Guy J, Maxwell BD, Priestley ES, Marinier A, Wexler RR, Bouvier M, Gordon DA, Schumacher WA, Yang J. Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding. Sci Transl Med. 2017 Jan 4;9(371). pii: eaaf5294. doi: 10.1126/scitranslmed.aaf5294. PubMed PMID: 28053157.