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MedKoo Cat#: 145129 | Name: Flubeneteram

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Flubeneteram (Flu) is a novel succinate dehydrogenase inhibitor (SDHI) which exhibits strong fungicidal activity against F. graminearum.

Chemical Structure

Flubeneteram
Flubeneteram
CAS#1676101-39-5

Theoretical Analysis

MedKoo Cat#: 145129

Name: Flubeneteram

CAS#: 1676101-39-5

Chemical Formula: C19H13ClF5N3O2

Exact Mass: 445.0616

Molecular Weight: 445.77

Elemental Analysis: C, 51.19; H, 2.94; Cl, 7.95; F, 21.31; N, 9.43; O, 7.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Flubeneteram; Y 13149;
IUPAC/Chemical Name
N-(2-(2-chloro-4-(trifluoromethyl)phenoxy)phenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide
InChi Key
YSVSUCSNKUVUFZ-UHFFFAOYSA-N
InChi Code
1S/C19H13ClF5N3O2/c1-28-9-11(16(27-28)17(21)22)18(29)26-13-4-2-3-5-15(13)30-14-7-6-10(8-12(14)20)19(23,24)25/h2-9,17H,1H3,(H,26,29)
SMILES Code
CN1C=C(C(=O)NC2=CC=CC=C2OC3=CC=C(C=C3Cl)C(F)(F)F)C(=N1)C(F)F
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 445.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ji F, Zhang J, Chen X, Liu B, Zhou A, Feng Y, Zhao J, Huang L, Kang Z, Zhan G. Effects of Flubeneteram on Inhibiting the Development of Puccinia striiformis f. sp. tritici in Wheat Leaves. J Agric Food Chem. 2023 Apr 5;71(13):5162-5171. doi: 10.1021/acs.jafc.3c00499. Epub 2023 Mar 22. PMID: 36946748. 2: Chen W, Wei L, Li X, Ma H, Lou T, Zhang P, Zheng H, Zhu X, Zhang Y, Liu F, Chen C, Yang G. Point Mutations in FgSdhC2 or in the 5' Untranslated Region of FgSdhC1 Confer Resistance to a Novel Succinate Dehydrogenase Inhibitor Flubeneteram in Fusarium graminearum. J Agric Food Chem. 2021 Nov 10;69(44):13006-13019. doi: 10.1021/acs.jafc.1c04363. Epub 2021 Nov 1. PMID: 34723519. 3: Wei G, Huang MW, Wang WJ, Wu Y, Mei SF, Zhou LM, Mei LC, Zhu XL, Yang GF. Expanding the Chemical Space of Succinate Dehydrogenase Inhibitors via the Carbon-Silicon Switch Strategy. J Agric Food Chem. 2021 Apr 7;69(13):3965-3971. doi: 10.1021/acs.jafc.0c07322. Epub 2021 Mar 28. PMID: 33779164. 4: Wang Q, Mao Y, Li S, Li T, Wang J, Zhou M, Duan Y. Molecular Mechanism of Sclerotinia sclerotiorum Resistance to Succinate Dehydrogenase Inhibitor Fungicides. J Agric Food Chem. 2022 Jun 15;70(23):7039-7048. doi: 10.1021/acs.jafc.2c02056. Epub 2022 Jun 6. PMID: 35666187. 5: He B, Chen W, Ma ZT, He X, Hu MX, Hu YH, Zhang XT, Yan W, Liu MX, Zhang ZG, Ye YH. Design and Synthesis of Novel Diphenyl Ether Carboxamide Derivatives To Control the Phytopathogenic Fungus Sclerotinia sclerotiorum. J Agric Food Chem. 2024 Feb 14;72(6):2935-2942. doi: 10.1021/acs.jafc.3c04595. Epub 2024 Feb 5. PMID: 38317284. 6: Li H, Gao MQ, Chen Y, Wang YX, Zhu XL, Yang GF. Discovery of Pyrazine- Carboxamide-Diphenyl-Ethers as Novel Succinate Dehydrogenase Inhibitors via Fragment Recombination. J Agric Food Chem. 2020 Nov 25;68(47):14001-14008. doi: 10.1021/acs.jafc.0c05646. Epub 2020 Nov 13. PMID: 33185088. 7: Zhan G, Ji F, Zhao J, Liu Y, Zhou A, Xia M, Zhang J, Huang L, Guo J, Kang Z. Sensitivity and Resistance Risk Assessment of Puccinia striiformis f. sp. tritici to Triadimefon in China. Plant Dis. 2022 Jun;106(6):1690-1699. doi: 10.1094/PDIS-10-21-2168-RE. Epub 2022 May 6. PMID: 34962420. 8: Ji F, Zhou A, Liu B, Liu Y, Feng Y, Wang X, Huang L, Kang Z, Zhan G. Sensitivity of Puccinia triticina f. sp. tritici from China to Triadimefon and Resistance Risk Assessment. Plant Dis. 2023 Dec;107(12):3877-3885. doi: 10.1094/PDIS-02-23-0277-RE. Epub 2023 Dec 5. PMID: 37311234. 9: Luo B, Zhao Y, Zhang J, Li W, Liu M, Yang M, Wei L, Liu Y, Wen B, Qu L. Design, Synthesis, and Antifungal Activities of Novel Pyrazole-4-carboxamide Derivatives Containing an Ether Group as Potential Succinate Dehydrogenase Inhibitors. J Agric Food Chem. 2023 Jun 21;71(24):9255-9265. doi: 10.1021/acs.jafc.3c00116. Epub 2023 Jun 7. PMID: 37283465.