Synonym
6-Nitroveratraldehyde; DMNB; NSC 65590; NSC65590; NSC-65590;
IUPAC/Chemical Name
4,5-dimethoxy-2-nitro-benzaldehyde
InChi Key
YWSPWKXREVSQCA-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H9NO5/c1-14-8-3-6(5-11)7(10(12)13)4-9(8)15-2/h3-5H,1-2H3
SMILES Code
COC1=CC([N+]([O-])=O)=C(C=O)C=C1OC
Purity
>97% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
DMNB (6-Nitroveratraldehyde), a precursor, can be used for the synthesis no-carrier-added 6-[18F]fluoro-L-DOPA (6-FDOPA).
In vitro activity:
By imaging the spread of H+ ions from a photochemically-activated source (6-nitroveratraldehyde), DCO2 in human RBCs was calculated to be only 5% of the rate in water.
Reference: Sci Rep. 2016 Oct 25;6:36018. https://pubmed.ncbi.nlm.nih.gov/27777410/
|
Solvent |
mg/mL |
mM |
| Solubility |
| DMSO |
100.0 |
473.55 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
211.17
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
1. Peeler JC, Weerapana E. Expression of selenoproteins via genetic code expansion in mammalian cells. Methods Enzymol. 2022;662:143-158. doi: 10.1016/bs.mie.2021.10.015. Epub 2021 Nov 24. PMID: 35101208; PMCID: PMC9531563.
2. Richardson SL, Swietach P. Red blood cell thickness is evolutionarily constrained by slow, hemoglobin-restricted diffusion in cytoplasm. Sci Rep. 2016 Oct 25;6:36018. doi: 10.1038/srep36018. PMID: 27777410; PMCID: PMC5078773.
In vitro protocol:
1. Peeler JC, Weerapana E. Expression of selenoproteins via genetic code expansion in mammalian cells. Methods Enzymol. 2022;662:143-158. doi: 10.1016/bs.mie.2021.10.015. Epub 2021 Nov 24. PMID: 35101208; PMCID: PMC9531563.
2. Richardson SL, Swietach P. Red blood cell thickness is evolutionarily constrained by slow, hemoglobin-restricted diffusion in cytoplasm. Sci Rep. 2016 Oct 25;6:36018. doi: 10.1038/srep36018. PMID: 27777410; PMCID: PMC5078773.
1. Hulikova, A., and Swietach, P. Nuclear proton dynamics and interactions with calcium signaling. J. Mol. Cell. Cardiol. 96, 26-37 (2016).
2. Richardson, S.L., and Swietach, P. Red blood cell thickness is evolutionarily constrained by slow, hemoglobin-restricted diffusion in cytoplasm. Sci. Rep. 6:36018, 1-11 (2016).
3. Hulikova, A., Black, N., Hsia, L.T., et al. Stromal uptake and transmission of acid is a pathway for venting cancer cell-generated acid. Proc. Natl. Acad. Sci. U.S.A. 113(36), 344-353 (2016).
4. Reddy, G.N., Haeberli, M., Beer, H.-F., et al. An improved synthesis of no-carrier-added (NCA) 6-[18F]Fluoro-l-DOPA and its remote routine production for PET investigations of dopaminergic systems. Appl. Radiat. Isot. 44(4), 645-649 (1993).
