Pipazethate | CAS# 2167-85-3 (free base) | non-narcotic oral antitussive agent

MedKoo Cat#: 318496 | Name: Pipazethate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pipazetate is a cough suppressant. It is a non-narcotic oral antitussive agent.

Chemical Structure

Pipazethate

CAS#2167-85-3 (free base)

Theoretical Analysis

MedKoo Cat#: 318496

Name: Pipazethate

CAS#: 2167-85-3 (free base)

Chemical Formula: C21H25N3O3S

Exact Mass: 399.1617

Molecular Weight: 399.51

Elemental Analysis: C, 63.13; H, 6.31; N, 10.52; O, 12.01; S, 8.03

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

6056-11-7 (HCl); 2167-85-3 (free base)

Synonym

Pipazethate; Pipazethate; Pipazetate; Theratuss; Lenopect; Pipazetatum [INN-Latin]; pipazethate monohydrochloride; Selvigon; Theratuss;

IUPAC/Chemical Name

2-(2-piperidin-1-ylethoxy)ethyl pyrido[3,2-b][1,4]benzothiazine-10-carboxylate

InChi Key

DTVJXCOMJLLMAK-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H25N3O3S/c25-21(27-16-15-26-14-13-23-11-4-1-5-12-23)24-17-7-2-3-8-18(17)28-19-9-6-10-22-20(19)24/h2-3,6-10H,1,4-5,11-16H2

SMILES Code

C1CCN(CC1)CCOCCOC(=O)N2C3=CC=CC=C3SC4=C2N=CC=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 399.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Gouda AA, El-Sheikh R, El Shafey Z, Hossny N, El-Azzazy R. Spectrophotometric Determination of Pipazethate HCl and Dextromethorphan HBr using Potassium Permanganate. Int J Biomed Sci. 2008 Dec;4(4):294-302. PubMed PMID: 23675101; PubMed Central PMCID: PMC3614715. 2: Melwanki MB, Seetharamappa J, Masti SP. Spectrophotometric determination of molybdenum(VI) using isothipendyl hydrochloride and pipazethate hydrochloride in alloy steels and soil samples. Anal Sci. 2001 Sep;17(9):1121-3. PubMed PMID: 11708072. 3: Abdel-Ghani NT, Shoukry AF, el Nashar RM. Flow injection potentiometric determination of pipazethate hydrochloride. Analyst. 2001 Jan;126(1):79-85. PubMed PMID: 11205518. 4: Soto E, Ochoa Z, Alvarado H, Espinoza OB, Irastorza IM, Ramirez MS. Pipazethate lethality in a baby. Vet Hum Toxicol. 1993 Feb;35(1):41. PubMed PMID: 8434453. 5: Bonavita V, Crinò C. Accidental lethal pipazethate poisoning in a child. Z Rechtsmed. 1982;89(2):145-8. PubMed PMID: 7180211. 6: Vakil BJ, Mehta AJ, Prajapat KD. Trial of pipazethate as an antitussive. Clin Pharmacol Ther. 1966 Jul-Aug;7(4):515-9. PubMed PMID: 5328471. 7: El-Shiekh R, Amin AS, Zahran F, Gouda AA. Spectrophotometric determination of pipazethate hydrochloride in pure form and in pharmaceutical formulations. J AOAC Int. 2007 May-Jun;90(3):686-92. PubMed PMID: 17580620. 8: Amin AS, El-Sheikh R, Zahran F, Gouda AA. Spectrophotometric determination of pipazethate HCl, dextromethorphan HBr and drotaverine HCl in their pharmaceutical preparations. Spectrochim Acta A Mol Biomol Spectrosc. 2007 Jul;67(3-4):1088-93. Epub 2006 Sep 28. PubMed PMID: 17092767. 9: Issa YM, Shoukry AF, El-Nashar RM. Conductimetric determination of reproterol HCl and pipazethate HCl and salbutamol sulphate in their pharmaceutical formulations. J Pharm Biomed Anal. 2001 Oct;26(3):379-86. PubMed PMID: 11489383. 10: da Silva OA, Lopez M. Pipazethate--acute childhood poisoning. Clin Toxicol. 1977;11(4):455-8. PubMed PMID: 589958. 11: Qualitative and quantitative tests for pipazethate hydrochloride. J Pharm Sci. 1965 Sep;54(9):1338-41. PubMed PMID: 5881232. 12: AMLER AB, ROTHMAN CB. EVALUATION OF PIPAZETHATE AS AN ANTITUSSIVE AGENT IN PEDIATRIC PRACTICE. J New Drugs. 1963 Nov-Dec;3(6):362-6. PubMed PMID: 14113560. 13: BECKLOFF GL, HEWITT MI. THE CLINICAL EVALUATION OF PIPAZETHATE ADMINISTERED RECTALLY IN 172 PEDIATRIC PATIENTS. Am J Med Sci. 1963 Sep;246:285-8. PubMed PMID: 14064876. 14: FISCHMAN ME. Pipazethate suppositories for the suppression of cough in pediatric practice. A report on 61 cases. Arch Pediatr. 1962 Sep;79:332-4. PubMed PMID: 13893186.