ARD-61 | CAS#2316837-08-6 | AR antagonist

MedKoo Cat#: 465420 | Name: ARD-61

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ARD-61 is an AR antagonist and PROTAC AR degrader.

Chemical Structure

ARD-61

CAS#2316837-08-6

Theoretical Analysis

MedKoo Cat#: 465420

Name: ARD-61

CAS#: 2316837-08-6

Chemical Formula: C61H71ClN8O7S

Exact Mass: 1094.4855

Molecular Weight: 1095.80

Elemental Analysis: C, 66.86; H, 6.53; Cl, 3.24; N, 10.23; O, 10.22; S, 2.93

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 2,650.00	2 Weeks

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Related CAS #

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Synonym

ARD-61; ARD61; ARD 61;

IUPAC/Chemical Name

(2S,4R)-N-((S)-3-(4-((4-(((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)carbamoyl)phenyl)ethynyl)-[1,4'-bipiperidin]-1'-yl)-1-(4-(4-methylthiazol-5-yl)phenyl)-3-oxopropyl)-4-hydroxy-1-((R)-3-methyl-2-(3-methylisoxazol-5-yl)butanoyl)pyrrolidine-2-carboxamide

InChi Key

RGPUSLXMPBTXNU-MLMZQBPXSA-N

InChi Code

InChI=1S/C61H71ClN8O7S/c1-36(2)53(51-29-37(3)67-77-51)57(75)70-34-46(71)30-50(70)56(74)65-49(41-15-17-42(18-16-41)54-38(4)64-35-78-54)32-52(72)69-27-23-45(24-28-69)68-25-21-40(22-26-68)10-9-39-11-13-43(14-12-39)55(73)66-58-60(5,6)59(61(58,7)8)76-47-20-19-44(33-63)48(62)31-47/h11-20,29,31,35-36,40,45-46,49-50,53,58-59,71H,21-28,30,32,34H2,1-8H3,(H,65,74)(H,66,73)/t46-,49+,50+,53-,58-,59-/m1/s1

SMILES Code

ClC1=CC(O[C@H]2C(C)(C)[C@H](NC(C3=CC=C(C#CC4CCN(C5CCN(C(C[C@@H](C6=CC=C(C7=C(C)N=CS7)C=C6)NC([C@H]8N(C([C@@H](C9=CC(C)=NO9)C(C)C)=O)C[C@H](O)C8)=O)=O)CC5)CC4)C=C3)=O)C2(C)C)=CC=C1C#N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,095.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhao L, Han X, Lu J, McEachern D, Wang S. A highly potent PROTAC androgen receptor (AR) degrader ARD-61 effectively inhibits AR-positive breast cancer cell growth in vitro and tumor growth in vivo. Neoplasia. 2020 Oct;22(10):522-532. doi: 10.1016/j.neo.2020.07.002. PMID: 32928363; PMCID: PMC7498667. 2: Kregel S, Wang C, Han X, Xiao L, Fernandez-Salas E, Bawa P, McCollum BL, Wilder-Romans K, Apel IJ, Cao X, Speers C, Wang S, Chinnaiyan AM. Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment. Neoplasia. 2020 Feb;22(2):111-119. doi: 10.1016/j.neo.2019.12.003. Epub 2020 Jan 10. PMID: 31931431; PMCID: PMC6957805.