MedKoo Cat#: 318776 | Name: Sulfathiazole
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sulfathiazole is an organosulfur compound used as a short-acting sulfa drug. It is an organic compound. Formerly, it was a common oral and topical antimicrobial, until less toxic alternatives were discovered. It is still occasionally used, sometimes in combination with sulfabenzamide and sulfacetamide, and in aquariums. It exists in various forms (polymorphs). The imine tautomer is dominant, at least in the solid state. In this tautomer, the proton resides on the ring nitrogen.

Chemical Structure

Sulfathiazole
Sulfathiazole
CAS#72-14-0

Theoretical Analysis

MedKoo Cat#: 318776

Name: Sulfathiazole

CAS#: 72-14-0

Chemical Formula: C9H9N3O2S2

Exact Mass: 255.0136

Molecular Weight: 255.31

Elemental Analysis: C, 42.34; H, 3.55; N, 16.46; O, 12.53; S, 25.11

Price and Availability

Size Price Availability Quantity
25g USD 300.00 2 weeks
100g USD 550.00 2 weeks
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Related CAS #
No Data
Synonym
HSDB4380; HSDB-4380; HSDB 4380; Sulfathiazole; Planomide; Poliseptil
IUPAC/Chemical Name
4-amino-N-(thiazol-2-yl)benzenesulfonamide
InChi Key
JNMRHUJNCSQMMB-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H9N3O2S2/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9/h1-6H,10H2,(H,11,12)
SMILES Code
O=S(NC1=NC=CS1)(C2=CC=C(N)C=C2)=O
Appearance
White to off-white crystalline powder.
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
Sulfathiazole is a short-acting sulfonamide antibiotic.
In vitro activity:
To be determined
In vivo activity:
Sulfathiazole along with CYP19A1 target bring new promise for the better therapy of type 2 diabetes mellitus (T2DM). Sulfathiazole decreased the blood glucose and improved glucose metabolism in T2DM mice. Additionally, sulfathiazole treated T2DM by activating CYP19A1 protein to synthesize estrogen. Reference: Biochim Biophys Acta Gen Subj. 2023 Mar;1867(3):130303. https://pubmed.ncbi.nlm.nih.gov/36627088/
Solvent mg/mL mM
Solubility
DMSO 250.0 979.16
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 255.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Hu Z, Li C, Wu T, Zhou J, Han L, Liu J, Qiang S, Zhao W, Li X, Liu X, Li J, Chen X. Sulfathiazole treats type 2 diabetes by restoring metabolism through activating CYP19A1. Biochim Biophys Acta Gen Subj. 2023 Mar;1867(3):130303. doi: 10.1016/j.bbagen.2023.130303. Epub 2023 Jan 7. PMID: 36627088. 2. Ji K, Choi K, Lee S, Park S, Khim JS, Jo EH, Choi K, Zhang X, Giesy JP. Effects of sulfathiazole, oxytetracycline and chlortetracycline on steroidogenesis in the human adrenocarcinoma (H295R) cell line and freshwater fish Oryzias latipes. J Hazard Mater. 2010 Oct 15;182(1-3):494-502. doi: 10.1016/j.jhazmat.2010.06.059. Epub 2010 Jun 19. PMID: 20630653.
In vitro protocol:
To be determined
In vivo protocol:
1. Hu Z, Li C, Wu T, Zhou J, Han L, Liu J, Qiang S, Zhao W, Li X, Liu X, Li J, Chen X. Sulfathiazole treats type 2 diabetes by restoring metabolism through activating CYP19A1. Biochim Biophys Acta Gen Subj. 2023 Mar;1867(3):130303. doi: 10.1016/j.bbagen.2023.130303. Epub 2023 Jan 7. PMID: 36627088. 2. Ji K, Choi K, Lee S, Park S, Khim JS, Jo EH, Choi K, Zhang X, Giesy JP. Effects of sulfathiazole, oxytetracycline and chlortetracycline on steroidogenesis in the human adrenocarcinoma (H295R) cell line and freshwater fish Oryzias latipes. J Hazard Mater. 2010 Oct 15;182(1-3):494-502. doi: 10.1016/j.jhazmat.2010.06.059. Epub 2010 Jun 19. PMID: 20630653.
1: Kabra SK, Lodha R. Antibiotics for preventing complications in children with measles. Cochrane Database Syst Rev. 2013 Aug 14;8:CD001477. doi: 10.1002/14651858.CD001477.pub4. Review. PubMed PMID: 23943263. 2: Abu Bakar MR, Nagy ZK, Rielly CD, Dann SE. Investigation of the riddle of sulfathiazole polymorphism. Int J Pharm. 2011 Jul 29;414(1-2):86-103. doi: 10.1016/j.ijpharm.2011.05.004. Epub 2011 May 10. Review. PubMed PMID: 21596117. 3: Kabra SK, Lodha R, Hilton DJ. Antibiotics for preventing complications in children with measles. Cochrane Database Syst Rev. 2008 Jul 16;(3):CD001477. doi: 10.1002/14651858.CD001477.pub3. Review. Update in: Cochrane Database Syst Rev. 2013;8:CD001477. PubMed PMID: 18646073. 4: Heifets LB. Antimycobacterial drugs. Semin Respir Infect. 1994 Jun;9(2):84-103. Review. Erratum in: Semin Respir Infect 1995 Jun;10(2):121. PubMed PMID: 7973175. 5: Paynter OE, Burin GJ, Jaeger RB, Gregorio CA. Goitrogens and thyroid follicular cell neoplasia: evidence for a threshold process. Regul Toxicol Pharmacol. 1988 Mar;8(1):102-19. Review. PubMed PMID: 3285378. 6: Makarov VA, Kudrin AN. [Mechanism of absorption and acetylation of sulfanilamides in the body]. Klin Med (Mosk). 1983 Nov;61(11):17-21. Review. Russian. PubMed PMID: 6363811. 7: Hekster CA, Vree TB. Clinical pharmacokinetics of sulphonamides and their N4-acetyl derivatives. Antibiot Chemother (1971). 1982;31:22-118. Review. PubMed PMID: 7036849.