MedKoo Cat#: 574429 | Name: TCS-1105
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TCS-1105 is a GABAA benzodiazepine receptor (BZR) ligand that acts as an agonist at α2 and antagonist at α1 benzodiazepine receptors. It is also an anxiolytic agent lacking sedative activity.

Chemical Structure

TCS-1105
TCS-1105
CAS#185391-33-7

Theoretical Analysis

MedKoo Cat#: 574429

Name: TCS-1105

CAS#: 185391-33-7

Chemical Formula: C17H13FN2O2

Exact Mass: 296.0961

Molecular Weight: 296.30

Elemental Analysis: C, 68.91; H, 4.42; F, 6.41; N, 9.45; O, 10.80

Price and Availability

Size Price Availability Quantity
10mg USD 450.00 2 Weeks
50mg USD 1,150.00 2 Weeks
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Related CAS #
No Data
Synonym
TCS-1105, TCS1105, TCS 1105
IUPAC/Chemical Name
N-[(-4-Fluorophenyl)methyl]-α-oxo-1H-indole-3-acetamide
InChi Key
VWCCHJFFYCGXFL-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H13FN2O2/c18-12-7-5-11(6-8-12)9-20-17(22)16(21)14-10-19-15-4-2-1-3-13(14)15/h1-8,10,19H,9H2,(H,20,22)
SMILES Code
O=C(NCC1=CC=C(F)C=C1)C(C2=CNC3=C2C=CC=C3)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 296.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Taliani et al (2009) Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABAA) α2 benzodiazepine receptor. J.Med.Chem 52 3723 PMID: 19469479 2: Xu, J., Xu, M., Wang, Y., Mathena, R. P., Wen, J., Zhang, P., ... & Mintz, C. D. (2019). Anesthetics disrupt growth cone guidance cue sensing through actions on the GABAA α2 receptor mediated by the immature chloride gradient. Neurotoxicology and teratology, 74, 106812.