MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 318757 | Name: Stepronin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Stepronin is a mucolytic and expectorant.

Chemical Structure

Stepronin
Stepronin
CAS#72324-18-6 (free acid)

Theoretical Analysis

MedKoo Cat#: 318757

Name: Stepronin

CAS#: 72324-18-6 (free acid)

Chemical Formula: C10H11NO4S2

Exact Mass: 273.0129

Molecular Weight: 273.32

Elemental Analysis: C, 43.94; H, 4.06; N, 5.12; O, 23.41; S, 23.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
78126-10-0 (sodium) 72324-18-6 (free acid) 113790-28-6 (lysine salt)
Synonym
Stepronin; Tiase; Tiofacic
IUPAC/Chemical Name
(2-((thiophene-2-carbonyl)thio)propanoyl)glycine
InChi Key
JNYSEDHQJCOWQU-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H11NO4S2/c1-6(9(14)11-5-8(12)13)17-10(15)7-3-2-4-16-7/h2-4,6H,5H2,1H3,(H,11,14)(H,12,13)
SMILES Code
O=C(O)CNC(C(SC(C1=CC=CS1)=O)C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 273.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: de Giorgi L, Habeshaw JA, Broadhurst K, Carminati P, Oxford JS. Anti-human immunodeficiency virus activity of a new immunosuppressant drug called stepronin. Transplant Proc. 1999 Dec;31(8):3257. PubMed PMID: 10616467. 2: Romano A, Di Fonso M, Mormile F, Quaratino D, Giuffreda F, Venuti A. Accelerated cell-mediated broncho-obstructive reaction to inhaled stepronin: a case report. Allergy. 1996 Apr;51(4):269-71. PubMed PMID: 8792926. 3: Kim HY, Thomas D, Hanley MR. Stimulation of Ca(2+)-dependent membrane currents in Xenopus oocytes by microinjection of pyrimidine nucleotide-glucose conjugates. Mol Pharmacol. 1996 Feb;49(2):360-4. PubMed PMID: 8632770. 4: de Giorgi L, Arrigoni-Martelli E, Matossian-Rogers A. Immunosuppressive effect of stepronin (TS-5010680) in mice. Transplant Proc. 1994 Dec;26(6):3513-6. PubMed PMID: 7998255. 5: Yamada K, Satoh M, Shimura S, Sasaki T, Takishima T, Shirato K. An expectorant, stepronin, reduces airway secretion in vitro. Respiration. 1994;61(1):42-7. PubMed PMID: 8177972. 6: Romano A, Pietrantonio F, di Fonso M, Pocobelli D, Venuti A. Delayed hypersensitivity to stepronin: a case report. Contact Dermatitis. 1993 Sep;29(3):166. PubMed PMID: 8222642. 7: Marzo A, Bruno G, Nava D, Giubilei C, Arrigoni Martelli E, Douin MJ, Chassard D, Mignot A, Thebault JJ. Pharmacokinetics of 2-(alpha-thenoylthio)-propionylglycine (TTPG) in healthy volunteers--an oral dose-proportionality investigation. J Pharm Biomed Anal. 1992 Sep;10(9):623-9. PubMed PMID: 1286128. 8: Marzo A, Arrigoni Martelli E, Bruno G, Nava D, Mignot A, Vidal R, Lefebvre MA. High-performance liquid chromatographic evaluation of 2-(alpha-thenoylthio)propionylglycine and its two metabolites in biological fluids. J Chromatogr. 1991 Jan 4;536(1-2):327-35. PubMed PMID: 2050772. 9: De Rensis L, Schianchi L, Assunto A, Antenora G, Allocca F, Bossone V. [A controlled clinical study on the efficacy and tolerability of stepronin in chronic alcoholic liver diseases]. Clin Ter. 1990 Nov 15;135(3):209-13. Italian. PubMed PMID: 2150022. 10: Guslandi M, Barbieri P, Gaiani P, Nannini D. Noninvolvement of gastric mucus in the mucolytic effect of stepronine lysine salt. Int J Clin Pharmacol Res. 1988;8(3):223-5. PubMed PMID: 3403109. 11: Braga PC, Bossi R, Allegra L. Rheological modifications of mucus in chronic bronchitic patients after treatment with stepronine-lysine salt. Drugs Exp Clin Res. 1987;13(11):707-10. PubMed PMID: 3443046. 12: Ardizzi A, Della Toffola A, Galietti F, Giorgis GE, Miravalle C, Oliaro A, Scappaticci E. [Efficacy of the simultaneous aerosol administration of fenoterol and 2(alpha-thenoylthio)propionylglycine]. Minerva Med. 1986 Oct 13;77(39):1823-6. Italian. PubMed PMID: 3534632. 13: Duranti L, Galmuzzi G, Zeuli L, Oriani G, Lisciani R. Gastrointestinal absorption of 2-(alpha-thenoylthio)propionylglycine (TTPG) in healthy volunteers: a comparative study between two different pharmaceutical forms. Farmaco Prat. 1985 Oct;40(10):347-54. PubMed PMID: 4065320. 14: Olivieri D, Bernareggi V, Quitadamo M. [Effect of lysine stepronin salts on mucociliary clearance]. Arch Monaldi. 1985 Sep-Dec;40(5-6):211-7. Italian. PubMed PMID: 3843171. 15: Davis SS, Cox A, Marriott C, Readman AS, Barrett-Bee K. A new mucotropic agent--in vitro and in vivo evaluation of 2-alpha-thenoylthiopropionylglycine (bronchoplus). Eur J Respir Dis. 1985 Aug;67(2):94-102. PubMed PMID: 4054265. 16: Dotta F, Ciani A, Acone A, Nava D. [Efficacy of mucotropic agents in the treatment of bronchial asthma. Preliminary study of 2-(alpha-thenoylthio)-propionylglycine]. Clin Ter. 1983 May 31;105(4):307-16. Italian. PubMed PMID: 6872473. 17: Morale MC, Fiumara A, Bousquet E, Matera M, Guarcello V, Rizza V. The effects of 2-(alpha-Tenoyl) thiopropionylglycine (TTPG) on human lung mucus. Int J Tissue React. 1983;5(2):231-5. PubMed PMID: 6618789. 18: Bosio G, Bramato C, Salassa B, Andreoni G, Magliocca R. [The therapeutic activity of stepronin in viral hepatitis]. Minerva Med. 1982 Oct 27;73(41):2897-904. Italian. PubMed PMID: 6752758. 19: Bruno M, Fruttero B, Marangella M, Linari F. [Cystinuria: clinical and therapeutic aspects]. Boll Chim Farm. 1982 Feb;121(2):1S-8S. Italian. PubMed PMID: 7126344. 20: Radice G, Rugarli G. [Effect of stepronin on alcohol metabolism. An experimental study in the rabbit]. Boll Chim Farm. 1982 Feb;121(2):91-6. Italian. PubMed PMID: 6751354.