Pheniramine Maleate | CAS#132-20-7 | H1 Histamine Receptor Antagonist

MedKoo Cat#: 318480 | Name: Pheniramine Maleate

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pheniramine Maleate is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus. It is a H1 histamine receptor antagonist with little sedative action.

Chemical Structure

Pheniramine Maleate

CAS#132-20-7 (maleate)

Theoretical Analysis

MedKoo Cat#: 318480

Name: Pheniramine Maleate

CAS#: 132-20-7 (maleate)

Chemical Formula: C20H24N2O4

Exact Mass:

Molecular Weight: 356.42

Elemental Analysis: C, 67.40; H, 6.79; N, 7.86; O, 17.96

Price and Availability

Size	Price	Availability	Quantity
5g	USD 250.00
10g	USD 450.00
20g	USD 650.00
50g	USD 950.00

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Related CAS #

132-20-7 (maleate) 86-21-5 (free base) 25332-09-6 (HCl)

Synonym

Pheniramine Maleate; Daneral; Trimetose; Naphcon a; Pheniramine (Maleate); Prophenpyridamine; aneral Histapyridamine; Maleate, Pheniramine; Pheniramine; Pheniramine; Bimaleate; Pheniramine Maleate; Propheniramine

IUPAC/Chemical Name

N,N-dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

InChi Key

SSOXZAQUVINQSA-BTJKTKAUSA-N

InChi Code

InChI=1S/C16H20N2.C4H4O4/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16;5-3(6)1-2-4(7)8/h3-10,12,15H,11,13H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

SMILES Code

O=C(O)/C=C\C(O)=O.CN(C)CCC(C1=CC=CC=C1)C2=NC=CC=C2

Appearance

White to off-white crystalline powder.

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Pheniramine Maleate is a H1 histamine receptor antagonist.

In vitro activity:

TBD

In vivo activity:

The aim of this study is to investigate the protective effects of methylprednisolone (MP) and pheniramine maleate (PM) on reperfusion injury of lungs developing after ischemia of the left lower extremity of rats. Malondialdehyde levels were significantly lower in Ph group than in I/R group (P < .05). Superoxide dismutase and glutathione peroxidase enzyme activities were found to be significantly higher in Ph group than in the I/R group (P < .05). Histological examination demonstrated that PM had protective effects against I/R injury. Reference: Vasc Endovascular Surg. 2013 Apr;47(3):219-24. https://pubmed.ncbi.nlm.nih.gov/23377174/

	Solvent	mg/mL	mM	comments
Solubility
	Water	71.3	200.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 356.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Yuvanc E, Tuglu D, Ozan T, Kisa U, Balci M, Batislam E, Yilmaz E. Investigation of the antioxidant effects of pheniramine maleate and nebivolol on testicular damage in rats with experimentally induced testis torsion. Acta Cir Bras. 2018 Feb;33(2):125-133. doi: 10.1590/s0102-865020180020000004. PMID: 29513811. 2. Gokalp O, Yurekli I, Kiray M, Bagriyanik A, Yetkin U, Yurekli BS, Gur S, Aksun M, Satoglu IS, Gokalp G, Gurbuz A. Assessment of protective effects of pheniramine maleate on reperfusion injury in lung after distant organ ischemia: a rat model. Vasc Endovascular Surg. 2013 Apr;47(3):219-24. doi: 10.1177/1538574413475885. Epub 2013 Jan 31. PMID: 23377174.

In vitro protocol:

TBD

In vivo protocol:

1: Yektaş A, Gümüş F, Totoz T, Gül N, Erkalp K, Alagöl A. EFFECTS OF DEXAMETHASONE AND PHENIRAMINE MALEATE ON HEMODYNAMIC AND RESPIRATORY PARAMETERS AFTER CEMENTATION IN CEMENTED PARTIAL HIP PROSTHESIS. Middle East J Anaesthesiol. 2015 Feb;23(1):55-62. PubMed PMID: 26121896. 2: Venugopal K, Reddy MM, Bharathraj MY, Jaligidad K, Kushal DP. Pheniramine Maleate-Induced Rhabdomyolysis and Aki: Is it Fatal? Toxicol Int. 2014 Sep-Dec;21(3):319-21. doi: 10.4103/0971-6580.155384. PubMed PMID: 25948974; PubMed Central PMCID: PMC4413418. 3: Shrestha BB, Karmacharya M, Gharti BB, Timilsina B, Ghimire P. Effect of Dexamethasone and Pheniramine Maleate in Patients Undergoing Elective Laparoscopic Cholecystectomy. JNMA J Nepal Med Assoc. 2014 Jul-Sep;52(195):920-4. PubMed PMID: 26982667. 4: Huang T, Chen N, Wang D, Lai Y, Cao Z. A validated stability-indicating HPLC method for the simultaneous determination of pheniramine maleate and naphazoline hydrochloride in pharmaceutical formulations. Chem Cent J. 2014 Feb 1;8(1):7. doi: 10.1186/1752-153X-8-7. PubMed PMID: 24485011; PubMed Central PMCID: PMC3931327. 5: Yürekli I, Gökalp O, Kiray M, Gökalp G, Ergüneş K, Salman E, Yürekli BS, Satoğlu IS, Beşir Y, Cakır H, Gürbüz A. Effect of pheniramine maleate on reperfusion injury in brain tissue. Med Sci Monit Basic Res. 2013 Dec 6;19:285-90. doi: 10.12659/MSMBR.889570. PubMed PMID: 24309384; PubMed Central PMCID: PMC3867399. 6: Gokalp O, Yurekli I, Kiray M, Bagriyanik A, Yetkin U, Yurekli BS, Gur S, Aksun M, Satoglu IS, Gokalp G, Gurbuz A. Assessment of protective effects of pheniramine maleate on reperfusion injury in lung after distant organ ischemia: a rat model. Vasc Endovascular Surg. 2013 Apr;47(3):219-24. doi: 10.1177/1538574413475885. Epub 2013 Jan 31. PubMed PMID: 23377174. 7: Bayrak S, Yurekli I, Gokalp O, Kiray M, Bademci MS, Ozcem B, Besir Y, Yilik L, Kestelli M, Gurbuz A. Assessment of protective effects of methylprednisolone and pheniramine maleate on reperfusion injury in kidney after distant organ ischemia: a rat model. Ann Vasc Surg. 2012 May;26(4):559-65. doi: 10.1016/j.avsg.2012.01.006. Epub 2012 Mar 22. PubMed PMID: 22445244. 8: Paul G, Sood P, Paul BS, Puri S. Acute renal failure caused by pheniramine maleate induced rhabdomyolysis: an unusual case. Indian J Crit Care Med. 2009 Oct;13(4):221-3. doi: 10.4103/0972-5229.60176. PubMed PMID: 20436692; PubMed Central PMCID: PMC2856151. 9: Swamy PV, Divate SP, Shirsand SB, Rajendra P. Preparation and evaluation of orodispersible tablets of pheniramine maleate by effervescent method. Indian J Pharm Sci. 2009 Mar;71(2):151-4. doi: 10.4103/0250-474X.54284. PubMed PMID: 20336216; PubMed Central PMCID: PMC2839404. 10: Greiner JV, Udell IJ. A comparison of the clinical efficacy of pheniramine maleate/naphazoline hydrochloride ophthalmic solution and olopatadine hydrochloride ophthalmic solution in the conjunctival allergen challenge model. Clin Ther. 2005 May;27(5):568-77. PubMed PMID: 15978305. 11: Subramaniyan SP, Das SK. Rapid identification and quantification of chlorpheniramine maleate or pheniramine maleate in pharmaceutical preparations by thin-layer chromatography-densitometry. J AOAC Int. 2004 Nov-Dec;87(6):1319-22. PubMed PMID: 15675442. 12: Parente G, Pazzaglia M, Vincenzi C, Tosti A. Contact dermatitis from pheniramine maleate in eyedrops. Contact Dermatitis. 1999 Jun;40(6):338. PubMed PMID: 10385349. 13: Raval RC, Bilimoria FE, Patel HA. A comparative study of loratadine versus pheniramine maleate in chronic idiopathic urticaria. Indian J Dermatol Venereol Leprol. 1995 May-Jun;61(3):137-9. PubMed PMID: 20952926. 14: el-Gizawy SM, Ahmed Ael H. High-performance liquid chromatographic determination of mepyramine maleate, pheniramine maleate and phenylpropanolamine hydrochloride in tablets and drops. Analyst. 1987 Jun;112(6):867-9. PubMed PMID: 3619056. 15: Lucy CA, Cantwell FF. Simultaneous determination of phenylephrine hydrochloride and pheniramine maleate in nasal spray by solvent extraction-flow injection analysis using two porous-membrane phase separators and one photometric detector. Anal Chem. 1986 Nov;58(13):2727-31. PubMed PMID: 3813012. 16: Heidemann DR. High-pressure liquid chromatographic determination of methscopolamine nitrate, phenylpropanolamine hydrochloride, pyrilamine maleate, and pheniramine maleate in tablets. J Pharm Sci. 1981 Jul;70(7):820-2. PubMed PMID: 7264941. 17: Subramanyam S, Ganeshan S, Devi P. Action of anti-allergic agent pheniramine maleate on mammalian somatic & meiotic chromosomes. Indian J Exp Biol. 1981 Jun;19(6):516-9. PubMed PMID: 7275212. 18: Gupta VD, Ghanekar AG. Quantitative determinations of codeine phosphate, guaifenesin, pheniramine maleate, phenylpropanolamine hydrochloride, and pyrilamine maleate in an expectorant by high-pressure liquid chromatography. J Pharm Sci. 1977 Jun;66(6):895-7. PubMed PMID: 874803. 19: Rao KV. Effects of histamine and pheniramine maleate on protease activity of sheep brain. Indian J Physiol Pharmacol. 1973 Apr-Jun;17(2):121-3. PubMed PMID: 4148847. 20: Vakil BJ, Gaitonde BB, Chabria NL, Dattani KK, Oza SM. Comparative efficacy of pheniramine maleate and a combination of pheniramine maleate with prednisolone in reducing histamine induced triple response of the skin. Indian J Med Sci. 1973 Feb;27(2):114-9. PubMed PMID: 4574980.