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MedKoo Cat#: 318282 | Name: Mitiglinide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mitiglinide belongs to the meglitinide class of blood glucose-lowering drugs. It is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) K(ATP) channels in pancreatic beta-cells.

Chemical Structure

Mitiglinide
Mitiglinide
CAS#0145375-43-5

Theoretical Analysis

MedKoo Cat#: 318282

Name: Mitiglinide

CAS#: 0145375-43-5

Chemical Formula: C19H25NO3

Exact Mass: 315.1834

Molecular Weight: 315.41

Elemental Analysis: C, 72.35; H, 7.99; N, 4.44; O, 15.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Mitiglinide, Glufast, KAD-1229, S21403
IUPAC/Chemical Name
(2S)-4-[(3aS,7aR)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]-2-benzyl-4-oxobutanoic acid
InChi Key
WPGGHFDDFPHPOB-BBWFWOEESA-N
InChi Code
InChI=1S/C19H25NO3/c21-18(20-12-15-8-4-5-9-16(15)13-20)11-17(19(22)23)10-14-6-2-1-3-7-14/h1-3,6-7,15-17H,4-5,8-13H2,(H,22,23)/t15-,16+,17-/m0/s1
SMILES Code
O=C(O)[C@@H](CC1=CC=CC=C1)CC(N2C[C@]3([H])CCCC[C@]3([H])C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 315.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Phillippe HM, Wargo KA. Mitiglinide for type 2 diabetes treatment. Expert Opin Pharmacother. 2013 Oct;14(15):2133-44. doi: 10.1517/14656566.2013.834048. Epub 2013 Aug 30. Review. PubMed PMID: 23992284. 2: Konya H, Katsuno T, Tsunoda T, Yano Y, Kamitani M, Miuchi M, Hamaguchi T, Miyagawa J, Namba M. Effects of combination therapy with mitiglinide and voglibose on postprandial plasma glucose in patients with type 2 diabetes mellitus. Diabetes Metab Syndr Obes. 2013 Sep 2;6:317-25. doi: 10.2147/DMSO.S36046. Review. PubMed PMID: 24039439; PubMed Central PMCID: PMC3769413. 3: Kitasato L, Tojo T, Hatakeyama Y, Kameda R, Hashikata T, Yamaoka-Tojo M. Postprandial hyperglycemia and endothelial function in type 2 diabetes: focus on mitiglinide. Cardiovasc Diabetol. 2012 Jun 29;11:79. doi: 10.1186/1475-2840-11-79. Review. PubMed PMID: 22748110; PubMed Central PMCID: PMC3492036. 4: Phillippe HM, Wargo KA. Mitiglinide: a novel agent for the treatment of type 2 diabetes mellitus. Ann Pharmacother. 2010 Oct;44(10):1615-23. doi: 10.1345/aph.1P136. Epub 2010 Sep 14. Review. PubMed PMID: 20841518. 5: Malaisse WJ. Mitiglinide: a rapid- and short-acting non-sulfonylurea insulinotropic agent for the treatment of type 2 diabetic patients. Expert Opin Pharmacother. 2008 Oct;9(15):2691-8. doi: 10.1517/14656566.9.15.2691 . Review. PubMed PMID: 18803455. 6: Mitiglinide: KAD 1229, S 21403. Drugs R D. 2004;5(2):98-101. Review. PubMed PMID: 15293870. 7: Katahira H, Ishida H. [Effects of mitiglinide in treatment of impaired glucose tolerance]. Nihon Rinsho. 2005 Feb;63 Suppl 2:444-50. Review. Japanese. PubMed PMID: 15779420. 8: Odawara M. [Nateglinide and mitiglinide]. Nihon Rinsho. 2003 Jul;61(7):1230-7. Review. Japanese. PubMed PMID: 12877090. 9: Kusama H, Shibata N. [Mitiglinide (KAD-1229)]. Nihon Rinsho. 2002 Sep;60 Suppl 9:559-65. Review. Japanese. PubMed PMID: 12387051.