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MedKoo Cat#: 561599 | Name: Metrizoic Acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Metrizoic Acid is a molecule used as a radiographic contrast agent. Due to its high osmolality, Metrizoic Acid has a risk of inducing allergic reactions compared to lower osmolar contrast media.

Chemical Structure

Metrizoic Acid
Metrizoic Acid
CAS#1949-45-7

Theoretical Analysis

MedKoo Cat#: 561599

Name: Metrizoic Acid

CAS#: 1949-45-7

Chemical Formula: C12H11I3N2O4

Exact Mass: 627.7853

Molecular Weight: 627.94

Elemental Analysis: C, 22.95; H, 1.77; I, 60.63; N, 4.46; O, 10.19

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 Weeks
25g USD 550.00 2 weeks
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Related CAS #
No Data
Synonym
Metrizoic Acid; Metrizoate;
IUPAC/Chemical Name
3-Acetamido-5-[acetyl(methyl)amino]-2,4,6-triiodobenzoic acid
InChi Key
GGGDNPWHMNJRFN-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H11I3N2O4/c1-4(18)16-10-7(13)6(12(20)21)8(14)11(9(10)15)17(3)5(2)19/h1-3H3,(H,16,18)(H,20,21)
SMILES Code
O=C(O)C1=C(I)C(N(C(C)=O)C)=C(I)C(NC(C)=O)=C1I
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Metrizoic acid (Metrizoate) is an ionic contrast medium.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM comments
Solubility
DMSO 65.6 104.51
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 627.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Spinler SA, Goldfarb S. Nephrotoxicity of contrast media following cardiac angiography: pathogenesis, clinical course, and preventive measures, including the role of low-osmolality contrast media. Ann Pharmacother. 1992 Jan;26(1):56-64. Review. PubMed PMID: 1606346. 2: Almén T. Contrast media: the relation of chemical structure, animal toxicity and adverse clinical effects. Am J Cardiol. 1990 Oct 26;66(14):2F-8F. Review. PubMed PMID: 2239695. 3: Pokorny L, Kiss I, Karcsú S, Nehéz I, Feledi J, Vadon G. [Significance of low osmolarity contrast media in state of the art roentgen diagnosis]. Orv Hetil. 1989 Jun 18;130(25):1317-21. Review. Hungarian. PubMed PMID: 2664636. 4: Sergeev PV, Sviridov NK. [Effect of contrast media on the cardiovascular system (review of the literature)]. Farmakol Toksikol. 1977 Jul-Aug;40(4):498-503. Review. Russian. PubMed PMID: 332518. 5: Almén T. Angiography with metrizamide. Animal experiments and preliminary clinical experiences. Acta Radiol Suppl. 1977;355:419-30. Review. PubMed PMID: 400907. 6: Golman K. Urography. Physiological considerations on the excretion of contrast media. J Belge Radiol. 1977;60(3):229-38. Review. PubMed PMID: 338573. 7: Lazecki L. [Nephrotropic contrast media]. Pol Przegl Radiol Med Nukl. 1975 Mar-Apr;39(2):239-50. Review. Polish. PubMed PMID: 1096096.