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MedKoo Cat#: 318468 | Name: Pentolinium Tartrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pentolonium tartrate is a nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension.

Chemical Structure

Pentolinium Tartrate
Pentolinium Tartrate
CAS#52-62-0 (tartrate)

Theoretical Analysis

MedKoo Cat#: 318468

Name: Pentolinium Tartrate

CAS#: 52-62-0 (tartrate)

Chemical Formula: C23H42N2O12

Exact Mass:

Molecular Weight: 538.59

Elemental Analysis: C, 51.29; H, 7.86; N, 5.20; O, 35.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
144-44-5 (cation) 52-62-0 (tartrate)
Synonym
Pentolinium Tartrate ; Pendine; Recuryl; Tensilest; Pentalinium tartrate; Pentolinium bitartrate; Tartrate, Pentolinium; Tartrate, Pentolonium;
IUPAC/Chemical Name
1-methyl-1-[5-(1-methylpyrrolidin-1-ium-1-yl)pentyl]pyrrolidin-1-ium;(2R,3R)-2,3,4-trihydroxy-4-oxobutanoate
InChi Key
HSMKTIKKPMTUQH-UHFFFAOYSA-L
InChi Code
InChI=1S/C15H32N2.2C4H6O6/c1-16(12-6-7-13-16)10-4-3-5-11-17(2)14-8-9-15-17;2*5-1(3(7)8)2(6)4(9)10/h3-15H2,1-2H3;2*1-2,5-6H,(H,7,8)(H,9,10)/q+2;;/p-2
SMILES Code
C[N+]1(CCCC1)CCCCC[N+]2(CCCC2)C.C(C(C(=O)[O-])O)(C(=O)O)O.C(C(C(=O)[O-])O)(C(=O)O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 538.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: BECKER KL, SUTNICK AI. Paralytic ileus simulating acute intestinal obstruction due to pentolinium tartrate (Ansolysen). Ann Intern Med. 1961 Feb;54:313-9. PubMed PMID: 13688462. 2: Basta JW, Niejadlik K, Pallares V. Autonomic hyperreflexia: intraoperative control with pentolinium tartrate. Br J Anaesth. 1977 Nov;49(11):1087-91. PubMed PMID: 588388. 3: Pertwee RG, Tavendale R. Effects of delta 9-tetrahydrocannabinol, 2.4-dinitrophenol and pentolinium tartrate on behavioural thermoregulation in mice. Br J Pharmacol. 1979 May;66(1):39-50. PubMed PMID: 454949; PubMed Central PMCID: PMC2043799. 4: Jackson KL, Marques FZ, Watson AM, Palma-Rigo K, Nguyen-Huu TP, Morris BJ, Charchar FJ, Davern PJ, Head GA. A novel interaction between sympathetic overactivity and aberrant regulation of renin by miR-181a in BPH/2J genetically hypertensive mice. Hypertension. 2013 Oct;62(4):775-81. doi: 10.1161/HYPERTENSIONAHA.113.01701. Epub 2013 Jul 29. PubMed PMID: 23897069. 5: Jackson KL, Palma-Rigo K, Nguyen-Huu TP, Davern PJ, Head GA. Major contribution of the medial amygdala to hypertension in BPH/2J genetically hypertensive mice. Hypertension. 2014 Apr;63(4):811-8. doi: 10.1161/HYPERTENSIONAHA.113.02020. Epub 2014 Jan 20. PubMed PMID: 24446057. 6: THOMSEN P, ORTUZAR R. [Prolonged treatment of severe arterial hypertension with combined pentolinium tartrate, hydralazine and Rauwalfia]. Arch Inst Cardiol Mex. 1957 May-Jun;27(3):333-44. Spanish. PubMed PMID: 13445469. 7: WALDMAN S, PELNER L. Treatment of the ambulatory hypertensive patient with pentolinium tartrate; a method for regulating dosage. Am J Med Sci. 1956 Feb;231(2):140-50. PubMed PMID: 13282895. 8: PERRY HM Jr, SCHROEDER HA. The use of pentolinium tartrate with and without hydralazine in the treatment of severe hypertension. N Engl J Med. 1955 Jun 23;252(25):1057-66. PubMed PMID: 14383963. 9: AGREST A, HOOBLER SW. Long-term management of hypertension with pentolinium tartrate (ansolysen). J Am Med Assoc. 1955 Mar 19;157(12):999-1003. PubMed PMID: 14353636. 10: ASHBY DW, O'NEILL J, MACLEAN MC. Initial control of hypertension with pentolinium tartrate. Lancet. 1955 Jan 29;268(6857):224-8. PubMed PMID: 13234334. 11: A DOUBLE blind control study of antihypertensive agents. I. Comparative effectiveness of reserpine, reserpine and hydralazine, and three ganglionic blocking agents, chlorisondamine, mecamyamine, and pentolinium tartrate. Arch Intern Med. 1960 Jul;106:81-96. PubMed PMID: 13856546. 12: DAVIS E, LANDAU J, KELETI L. The effect of pentolinium tartrate (ansolysen) on blood pressure in terminal vessels and on capillary diameter. Am Heart J. 1959 May;57(5):747-50. PubMed PMID: 13649541. 13: BROWN JF, CROSLEY AP Jr, CRUMPTON CW, HUSTON JH, ROWE GG, TUCHMAN H. The acute hemodynamic and metabolic response of hypertensive patients to pentolinium tartrate. Circulation. 1956 Oct;14(4 Part 1):584-92. PubMed PMID: 13365064. 14: FREIS ED, WILSON IM. Results of prolonged treatment with pentolinium tartrate with special reference to the addition of Rauwolfia, hydralazine or both. Circulation. 1956 Jun;13(6):856-65. PubMed PMID: 13356441. 15: MCCLOSKEY BJ. Hematuria during treatment of severe hypertension with hexamethonium bromide and pentolinium tartrate. J Fla Med Assoc. 1955 Oct;42(4):278-9. PubMed PMID: 13263500. 16: BAIN CW, ASHTON F, JONES BP. The treatment of essential hypertension with pentolinium tartrate combined with Rauwolfia alkaloids. Br Med J. 1955 Apr 2;1(4917):817-8. PubMed PMID: 14351794; PubMed Central PMCID: PMC2061924. 17: Davern PJ, Chowdhury S, Jackson KL, Nguyen-Huu TP, Head GA. GABAA receptor dysfunction contributes to high blood pressure and exaggerated response to stress in Schlager genetically hypertensive mice. J Hypertens. 2014 Feb;32(2):352-62. doi: 10.1097/HJH.0000000000000015. PubMed PMID: 24270178. 18: Abegaz B, Davern PJ, Jackson KL, Nguyen-Huu TP, Bassi JK, Connelly A, Choong YT, Allen AM, Head GA. Cardiovascular role of angiotensin type1A receptors in the nucleus of the solitary tract of mice. Cardiovasc Res. 2013 Nov 1;100(2):181-91. doi: 10.1093/cvr/cvt183. Epub 2013 Jul 24. PubMed PMID: 23887975. 19: Muravchick S, Brown BT, Carrion H, Politano VA, Pallares V. Pentolinium for control of reflex hypertension in spinal cord injured patients. Paraplegia. 1979 Feb;16(4):350-6. PubMed PMID: 431965. 20: Chan YL, Orie NN, Dyson A, Taylor V, Stidwill RP, Clapp LH, Singer M. Inhibition of vascular adenosine triphosphate-sensitive potassium channels by sympathetic tone during sepsis. Crit Care Med. 2012 Apr;40(4):1261-8. doi: 10.1097/CCM.0b013e31823da98d. PubMed PMID: 22425821.