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MedKoo Cat#: 522676 | Name: LY-2608204
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY-2608204 is an activator of glucokinase (GK) with an EC50 value of 42 nM. LY2608204 decreases plasma glucose in a dose-dependent manner at both fasted and postprandial glucose levels. In 2010, LY-2608204 was entered clinical trials in Patients With Type 2 Diabetes.

Chemical Structure

LY-2608204
LY-2608204
CAS#1234703-40-2 (free base)

Theoretical Analysis

MedKoo Cat#: 522676

Name: LY-2608204

CAS#: 1234703-40-2 (free base)

Chemical Formula: C28H37N3O3S3

Exact Mass: 559.1997

Molecular Weight: 559.80

Elemental Analysis: C, 60.08; H, 6.66; N, 7.51; O, 8.57; S, 17.18

Price and Availability

Size Price Availability Quantity
25mg USD 150.00 2 weeks
50mg USD 250.00 2 weeks
100mg USD 450.00 2 weeks
200mg USD 750.00 2 weeks
500mg USD 1,250.00 2 weeks
1g USD 2,250.00 2 weeks
2g USD 3,650.00 2 weeks
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Related CAS #
1234703-40-2 (free base) Globalagliatin HCl
Synonym
LY-2608204; LY 2608204; LY2608204; Globalagliatin hydrochloride; GLOBALAGLIATIN HYDROCHLORIDE; CH9BD8J28R; SY-004 HYDROCHLORIDE; CHEMBL5095182; LY2608204 HYDROCHLORIDE
IUPAC/Chemical Name
(1R,2S)-2-cyclohexyl-1-(4-cyclopropylsulfonylphenyl)-N-[5-(2-pyrrolidin-1-ylethylsulfanyl)-1,3-thiazol-2-yl]cyclopropane-1-carboxamide
InChi Key
QIIVJLHCZUTGSD-CUBQBAPOSA-N
InChi Code
InChI=1S/C28H37N3O3S3/c32-26(30-27-29-19-25(36-27)35-17-16-31-14-4-5-15-31)28(18-24(28)20-6-2-1-3-7-20)21-8-10-22(11-9-21)37(33,34)23-12-13-23/h8-11,19-20,23-24H,1-7,12-18H2,(H,29,30,32)/t24-,28-/m0/s1
SMILES Code
O=C([C@@]1(C2=CC=C(S(=O)(C3CC3)=O)C=C2)[C@H](C4CCCCC4)C1)NC5=NC=C(SCCN6CCCC6)S5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Globalagliatin (LY2608204) is a activator of glucokinase (GK) with EC50 of 42 nM.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
DMF 33.0 58.95
DMF:PBS (pH 7.2) (1:2) 0.3 0.59
DMSO 79.0 141.12
Ethanol 35.0 62.52
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 559.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD