|
Solvent |
mg/mL |
mM |
comments |
Solubility |
DMF |
33.0 |
136.79 |
|
DMF:PBS (pH 7.2) (1:30) |
0.0 |
0.12 |
|
DMSO |
54.7 |
226.60 |
|
Ethanol |
31.0 |
128.50 |
|
Water |
3.0 |
12.44 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
241.24
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Dobek CE, Dipinto AA, Kuan AJ, Lam RW, Blumberger DM, Downar J, Daskalakis ZJ,
Vila-Rodriguez F. Sinus Tachycardia Induced by Methocarbamol and Repetitive
Transcranial Magnetic Stimulation (rTMS). Brain Stimul. 2016 Jan-Feb;9(1):156-8.
doi: 10.1016/j.brs.2015.10.012. Epub 2015 Nov 24. PubMed PMID: 26792632.
2: Knych HK, Stanley SD, Seminoff KN, McKemie DS, Kass PH. Pharmacokinetics of
methocarbamol and phenylbutazone in exercised Thoroughbred horses. J Vet
Pharmacol Ther. 2016 Feb 29. doi: 10.1111/jvp.12298. [Epub ahead of print] PubMed
PMID: 26924025.
3: Aljuhani O, Kopp BJ, Patanwala AE. Effect of Methocarbamol on Acute Pain After
Traumatic Injury. Am J Ther. 2015 Oct 8. [Epub ahead of print] PubMed PMID:
26469684.
4: Emrich OM, Milachowski KA, Strohmeier M. [Methocarbamol in acute low back
pain. A randomized double-blind controlled study]. MMW Fortschr Med. 2015 Jul;157
Suppl 5:9-16. doi: 10.1007/s15006-015-3307-x. Epub 2015 Jul 13. German. PubMed
PMID: 26168743.
5: Essam HM, Abd-El Rahman MK. Smart manipulation of ratio spectra for resolving
a pharmaceutical mixture of Methocarbamol and Paracetamol. Spectrochim Acta A Mol
Biomol Spectrosc. 2015 Apr 15;141:1-9. doi: 10.1016/j.saa.2015.01.017. Epub 2015
Jan 21. PubMed PMID: 25659736.
6: Saraji M, Khayamian T, Hashemian Z. Extraction of methocarbamol from human
plasma with a polypyrrole/multiwalled carbon nanotubes composite decorated with
magnetic nanoparticles as an adsorbent followed by electrospray ionization ion
mobility spectrometry detection. J Sep Sci. 2014 Dec;37(23):3518-25. doi:
10.1002/jssc.201400614. Epub 2014 Oct 21. PubMed PMID: 25243817.
7: Mansour AM, Shehab OR. Trapping of muscle relaxant methocarbamol degradation
product by complexation with copper(II) ion: spectroscopic and quantum chemical
studies. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Jul 15;128:263-71. doi:
10.1016/j.saa.2014.02.142. Epub 2014 Mar 12. PubMed PMID: 24674917.
8: Helmy SA, El-Bedaiwy HM. Simultaneous determination of paracetamol and
methocarbamol in human plasma By HPLC using UV detection with time programming:
application to pharmacokinetic study. Drug Res (Stuttg). 2014 Jul;64(7):363-7.
doi: 10.1055/s-0033-1358703. Epub 2013 Nov 20. PubMed PMID: 24258704.
9: Rumpler MJ, Colahan P, Sams RA. The pharmacokinetics of methocarbamol and
guaifenesin after single intravenous and multiple-dose oral administration of
methocarbamol in the horse. J Vet Pharmacol Ther. 2014 Feb;37(1):25-34. doi:
10.1111/jvp.12068. Epub 2013 Jul 17. PubMed PMID: 23859819.
10: Abdelwahab NS, Abdelrahman MM. Simultaneous determination of methocarbamol
and Ibuprofen by first derivative synchronous fluorescence spectroscopic method
in their binary mixture and spiked human plasma. J Fluoresc. 2014
Jan;24(1):129-35. doi: 10.1007/s10895-013-1276-9. Epub 2013 Aug 3. PubMed PMID:
23912962.
11: Draper WE, Bolfer L, Cottam E, McMichael M, Schubert T. Methocarbamol CRI for
symptomatic treatment of pyrethroid intoxication: a report of three cases. J Am
Anim Hosp Assoc. 2013 Sep-Oct;49(5):325-8. doi: 10.5326/JAAHA-MS-5835. Epub 2013
Mar 27. PubMed PMID: 23535756.
12: Pruitt BN 3rd. Methocarbamol suspension for the treatment of rhabdomyolysis
in equines. Int J Pharm Compd. 2013 Sep-Oct;17(5):384-7. PubMed PMID: 24459784.
13: Kuo K, Odunayo A. Adjunctive therapy with intravenous lipid emulsion and
methocarbamol for permethrin toxicity in 2 cats. J Vet Emerg Crit Care (San
Antonio). 2013 Jul-Aug;23(4):436-41. doi: 10.1111/vec.12070. Epub 2013 Jul 15.
PubMed PMID: 23855545.
14: El-Din MS, Eid M, Zeid AM. Simultaneous determination of methocarbamol and
aspirin by RP-HPLC using fluorescence detection with time programming: its
application to pharmaceutical dosage form. Luminescence. 2013
May-Jun;28(3):332-8. doi: 10.1002/bio.2386. Epub 2012 Jun 20. PubMed PMID:
22715138.
15: Looke TD, Kluth CT. Effect of preoperative intravenous methocarbamol and
intravenous acetaminophen on opioid use after primary total hip and knee
replacement. Orthopedics. 2013 Feb;36(2 Suppl):25-32. doi:
10.3928/01477447-20130122-54. PubMed PMID: 23379573.
16: Ali NW, Hegazy MA, Abdelkawy M, Abdelaleem EA. Simultaneous determination of
methocarbamol and ibuprofen or diclofenac potassium using mean centering of the
ratio spectra method. Acta Pharm. 2012 Jun;62(2):191-200. doi:
10.2478/v10007-012-0016-z. PubMed PMID: 22750817.
17: Minai-Tehrani D, Masoudnia A, Alavi S, Osmani R, Lotfi L, Asghari M,
Pirsalehi M, Sobhani-Damavandifar Z. Interaction of methocarbamol and yeast
sucrase induces enzyme inhibition. Drug Metabol Drug Interact. 2012;27(4):225-8.
PubMed PMID: 23023692.
18: Gholivand MB, Khodadadian M. Rationally designed molecularly imprinted
polymers for selective extraction of methocarbamol from human plasma. Talanta.
2011 Sep 15;85(3):1680-8. doi: 10.1016/j.talanta.2011.06.066. Epub 2011 Jul 2.
PubMed PMID: 21807239.
19: Elkady EF. Simultaneous spectrophotometric determination of diclofenac
potassium and methocarbamol in binary mixture using chemometric techniques and
artificial neural networks. Drug Test Anal. 2011 Apr;3(4):228-33. doi:
10.1002/dta.216. Epub 2010 Dec 29. PubMed PMID: 21500367.
20: Walash M, Belal F, Eid M, EL Abass SA. Spectrofluorometric determination of
methocarbamol in pharmaceutical preparations and human plasma. J Fluoresc. 2011
Mar;21(2):555-61. doi: 10.1007/s10895-010-0742-x. Epub 2010 Oct 9. PubMed PMID:
20936330.