Mepivacaine Hydrochloride | CAS#1722-62-9 | CAS#96-88-8 | Anesthetic

MedKoo Cat#: 318189 | Name: Mepivacaine Hydrochloride

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mepivacaine Hydrochloride is a local anesthetic. It reversibly blocks inward current of transient Na+, as well as the steady-state K+ outward current. Mepivacaine Hydrochloride blocks tandem pore (TASK) and Kv1.5, potassium channels in model systems.

Chemical Structure

Mepivacaine Hydrochloride

CAS#1722-62-9 (HCl)

Theoretical Analysis

MedKoo Cat#: 318189

Name: Mepivacaine Hydrochloride

CAS#: 1722-62-9 (HCl)

Chemical Formula: C15H23ClN2O

Exact Mass: 0.0000

Molecular Weight: 282.81

Elemental Analysis: C, 63.70; H, 8.20; Cl, 12.54; N, 9.91; O, 5.66

Price and Availability

Size	Price	Availability
1g	USD 350.00	2 weeks
2g	USD 600.00	2 weeks
5g	USD 1,150.00	2 weeks

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Related CAS #

1722-62-9 (HCl) 96-88-8 (free base)

Synonym

Mepivacaine Hydrochloride; Mepivacaine HCL; Mepivastesin; Carbocaina; Polocaine; Scandicain;

IUPAC/Chemical Name

N-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide;hydrochloride

InChi Key

RETIMRUQNCDCQB-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H22N2O.ClH/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3;/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18);1H

SMILES Code

CC1=C(C(=CC=C1)C)NC(=O)C2CCCCN2C.Cl

Appearance

White to off-white crystalline powder.

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Mepivacaine hydrochloride binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization.

In vitro activity:

The local anesthetics mepivacaine and S(-)-bupivacaine also blocked Na(v)1.8 and TTXs channels differentially. While mepivacaine displayed a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displayed a preference for TTXs Na(+) channels. Reference: Eur J Pharmacol. 2010 Mar 25;630(1-3):19-28. https://pubmed.ncbi.nlm.nih.gov/20044988/

In vivo activity:

The efficacy of topical anesthetics was evaluated in a preclinical rodent model of painful peripheral neuropathy induced by epineural administration of the HIV envelope protein gp120 delivered using saturated oxidized cellulose implanted around the sciatic nerve. Equipotent concentrations of mepivacaine and lidocaine applied topically to the tail of mice significantly increased tail withdrawal latencies in the tail flick test, demonstrating that both local anesthetics attenuate responding to a brief noxious stimulus. Reference: J Pain Res. 2016 Jun 6;9:361-71. https://pubmed.ncbi.nlm.nih.gov/27350758/

	Solvent	mg/mL	mM
Solubility
	Ethanol	8.0	28.29
	Water	78.5	277.57

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 282.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Mosqueira M, Aykut G, Fink RHA. Mepivacaine reduces calcium transients in isolated murine ventricular cardiomyocytes. BMC Anesthesiol. 2020 Jan 8;20(1):10. doi: 10.1186/s12871-019-0926-0. PMID: 31914932; PMCID: PMC6947945. 2. Leffler A, Reckzeh J, Nau C. Block of sensory neuronal Na+ channels by the secreolytic ambroxol is associated with an interaction with local anesthetic binding sites. Eur J Pharmacol. 2010 Mar 25;630(1-3):19-28. doi: 10.1016/j.ejphar.2009.12.027. Epub 2010 Jan 4. PMID: 20044988. 3. Sagen J, Castellanos DA, Hama AT. Antinociceptive effects of topical mepivacaine in a rat model of HIV-associated peripheral neuropathic pain. J Pain Res. 2016 Jun 6;9:361-71. doi: 10.2147/JPR.S104397. PMID: 27350758; PMCID: PMC4902250. 4. Satoh K, Chikuda M, Ohashi A, Kumagai M, Sato M, Joh S. The effect of mepivacaine on swine lingual, pulmonary and coronary arteries. BMC Anesthesiol. 2015 Jul 14;15:101. doi: 10.1186/s12871-015-0085-x. PMID: 26169676; PMCID: PMC4499916.

In vitro protocol:

In vivo protocol:

1. Sagen J, Castellanos DA, Hama AT. Antinociceptive effects of topical mepivacaine in a rat model of HIV-associated peripheral neuropathic pain. J Pain Res. 2016 Jun 6;9:361-71. doi: 10.2147/JPR.S104397. PMID: 27350758; PMCID: PMC4902250. 2. Satoh K, Chikuda M, Ohashi A, Kumagai M, Sato M, Joh S. The effect of mepivacaine on swine lingual, pulmonary and coronary arteries. BMC Anesthesiol. 2015 Jul 14;15:101. doi: 10.1186/s12871-015-0085-x. PMID: 26169676; PMCID: PMC4499916.

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