MedKoo Cat#: 317615 | Name: Dihydrotachysterol
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dihydrotachysterol is a synthetic vitamin D analog activated in the liver that does not require renal hydroxylation like vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). DHT has a rapid onset of action (2 hours), a shorter half-life, and a greater effect on mineralization of bone salts than does vitamin D.

Chemical Structure

Dihydrotachysterol
CAS#67-96-9

Theoretical Analysis

MedKoo Cat#: 317615

Name: Dihydrotachysterol

CAS#: 67-96-9

Chemical Formula: C28H46O

Exact Mass: 398.3549

Molecular Weight: 398.68

Elemental Analysis: C, 84.36; H, 11.63; O, 4.01

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
50mg USD 750.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Dihydrotachysterol; Parterol; Tachyrol; DHT2; Calcamine; Hytakerol; Dihidrotaquisterol;
IUPAC/Chemical Name
(1S,4S,E)-3-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylcyclohexanol
InChi Key
ILYCWAKSDCYMBB-OPCMSESCSA-N
InChi Code
InChI=1S/C28H46O/c1-19(2)20(3)9-10-22(5)26-15-16-27-23(8-7-17-28(26,27)6)12-13-24-18-25(29)14-11-21(24)4/h9-10,12-13,19-22,25-27,29H,7-8,11,14-18H2,1-6H3/b10-9+,23-12+,24-13+/t20-,21-,22+,25-,26+,27-,28+/m0/s1
SMILES Code
C[C@H](C(C)C)/C=C/[C@@H](C)[C@H]([C@]1(CCC/2)C)CC[C@@]1([H])C2=C\C=C3C[C@@H](O)CC[C@@H]/3C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
Dihydrotachysterol is a synthetic analog of vitamin D.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 398.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Voigts AL, Felsenfeld AJ, Llach F. The effects of calciferol and its metabolites on patients with chronic renal failure. I. Calciferol, dihydrotachysterol, and calcifediol. Arch Intern Med. 1983 May;143(5):960-3. Review. PubMed PMID: 6089682. 2: Quack I, Zwernemann C, Weiner SM, Sellin L, Henning BF, Waldherr R, Büchner NJ, Stegbauer J, Vonend O, Rump LC. Dihydrotachysterol therapy for hypoparathyroidism: consequences of inadequate monitoring. Five cases and a review. Exp Clin Endocrinol Diabetes. 2005 Jul;113(7):376-80. Review. PubMed PMID: 16025398. 3: Kaiser W, Mampel E. [New viewpoints on the therapy and prevention of renal osteopathy]. Z Gesamte Inn Med. 1977 Jun 15;32(12):254-9. Review. German. PubMed PMID: 333796. 4: NORDIO S, ANTENER I. [RICKETS. METABOLIC, NOSOLOGICAL, PREVENTIVE AND THERAPEUTIC PROBLEMS]. Minerva Pediatr. 1963 Aug 25;15:849-90. Review. Italian. PubMed PMID: 14087868. 5: PRIORESCHI P. EXPERIMENTAL CARDIAC NECROSIS. Biochem Clin. 1963;2:149-57. Review. PubMed PMID: 14095768. 6: SELYE H. CALCIPHYLAXIS. Marquette Med Rev. 1964 Jan;30:2-9. Review. PubMed PMID: 14119600. 7: Bosch R, Thijssen JH, Duursma SA. Action and metabolism of dihydrotachysterol2. J Steroid Biochem. 1987;27(4-6):829-36. Review. PubMed PMID: 3320562. 8: Haas HG, Dambacher MA, Guncaga J. [Hypo and hypercalcemia as an emergency]. Klin Wochenschr. 1975 May 15;53(10):451-9. Review. German. PubMed PMID: 1104994. 9: Kleeman CR, Massry SG, Coburn JW. The clinical physiology of calcium homeostasis, parathyroid hormone, and calcitonin. II. Calif Med. 1971 Apr;114(4):19-30. Review. PubMed PMID: 4927915; PubMed Central PMCID: PMC1501857. 10: Varga E. [Treatment of hypoparathyroidism]. Orv Hetil. 2005 May 15;146(20):1019-20. Review. Hungarian. PubMed PMID: 15945245. 11: Bruyette DS, Feldman EC. Primary hypoparathyroidism in the dog. Report of 15 cases and review of 13 previously reported cases. J Vet Intern Med. 1988 Jan-Mar;2(1):7-14. Review. PubMed PMID: 3065494. 12: van der Spuy ZM, Jacobs HS. Management of endocrine disorders in pregnancy Part I--thyroid and parathyroid disease. Postgrad Med J. 1984 Apr;60(702):245-52. Review. PubMed PMID: 6374643; PubMed Central PMCID: PMC2417828. 13: Anast CS. Parathyroid disorders in children. Pediatr Ann. 1980 Oct;9(10):376-83. Review. PubMed PMID: 7003518. 14: Reeve J. Therapeutic applications of vitamin D analogues. Br Med J. 1979 Oct 13;2(6195):888-90. Review. PubMed PMID: 391320; PubMed Central PMCID: PMC1596737. 15: Harrrison HE, Harrison HC. Rickets then and now. J Pediatr. 1975 Dec;87(6 Pt 2):1144-51. Review. PubMed PMID: 1102648. 16: Avioli LV. The therapeutic approach to hypoparathyroidism. Am J Med. 1974 Jul;57(1):34-42. Review. PubMed PMID: 4601117. 17: Steendijk R. The metabolism of vitamin D; recent developments and their clinical relevance. Neth J Med. 1974;17(3):131-9. Review. PubMed PMID: 4367820. 18: Knowles JA. Breast milk: a source of more than nutrition for the neonate. Clin Toxicol. 1974;7(1):69-82. Review. PubMed PMID: 4135128. 19: Coburn JW, Norman AW. Editorial: Role of the kidney in the metabolism of calciferol (vitamin D). Clin Nephrol. 1973 Sep-Oct;1(5):273-83. Review. PubMed PMID: 4358418. 20: Brickman AS, Norman AW. Treatment of renal osteodystrophy with calciferol (vitamin D) and related steroids. Kidney Int. 1973 Aug;4(2):161-7. Review. PubMed PMID: 4364427.