Synonym
                                        Hydroflumethiazide; Diuredemina; Glomerulin; Hidroflumetiazid; Diurometon; Flutizide;  
                                     
                                    
                                        IUPAC/Chemical Name
                                        1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
                                     
                                    
                                        InChi Key
                                        DMDGGSIALPNSEE-UHFFFAOYSA-N
                                     
                                    
                                        InChi Code
                                        InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16)
                                     
                                    
                                        SMILES Code
                                        C1NC2=C(C=C(C(=C2)C(F)(F)F)S(=O)(=O)N)S(=O)(=O)N1
                                     
                                    
                                    
                                        Purity
                                        >98% (or refer to the Certificate of Analysis)
                                     
                                    
                                        Shipping Condition
                                        Shipped under ambient temperature as non-hazardous chemical.  This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
                                     
                                    
                                        Storage Condition
                                        Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
                                     
                                    
                                        Solubility
                                        Soluble in DMSO, not in water
                                     
                                    
                                        Shelf Life
                                        >2 years if stored properly
                                     
                                    
                                        Drug Formulation
                                        This drug may be formulated in DMSO
                                     
                                    
                                        Stock Solution Storage
                                        0 - 4 C for short term (days to weeks), or -20 C for long term (months).
                                     
                                    
                                        HS Tariff Code
                                        2934.99.9001
                                     
                                    
                                 
                             
                            
                                                        
                                                                
                                    Preparing Stock Solutions
                                    
                                        The following data is based on the
                                        product
                                        molecular weight
                                        331.29
                                        Batch specific molecular weights may vary
                                        from batch to batch
                                        due to the degree of hydration, which will
                                        affect the solvent
                                        volumes required to prepare stock solutions.
                                    
                                    
                                    
                                        
                                            
                                            
                                                | Concentration / Solvent Volume / Mass | 
                                                1 mg | 
                                                5 mg | 
                                                10 mg | 
                                            
                                            
                                            
                                            
                                                | 1 mM | 
                                                1.15 mL | 
                                                5.76 mL | 
                                                11.51 mL | 
                                            
                                            
                                                | 5 mM | 
                                                0.23 mL | 
                                                1.15 mL | 
                                                2.3 mL | 
                                            
                                            
                                                | 10 mM | 
                                                0.12 mL | 
                                                0.58 mL | 
                                                1.15 mL | 
                                            
                                            
                                                | 50 mM | 
                                                0.02 mL | 
                                                0.12 mL | 
                                                0.23 mL | 
                                            
                                            
                                        
                                     
                                 
                                                             
                            
                            
                                
                                    1: Ogola EN, Yonga GO. Comparative study of the efficacy and tolerability of
hydroflumethiazide versus propranolol in Africans with mild to moderate
hypertension. East Afr Med J. 1993 May;70(5):277-9. PubMed PMID: 8306902.
2: Agrawal YK, Giridhar R, Menon SK. Spectrophotometric determination of
hydroflumethiazide. J Pharm Biomed Anal. 1989;7(6):759-63. PubMed PMID: 2490778.
3: Hermansen K, Schmitz O, Mogensen CE. Effects of a thiazide diuretic
(hydroflumethiazide) and a loop diuretic (bumetanide) on the endocrine pancreas: 
studies in vitro. Metabolism. 1985 Aug;34(8):784-9. PubMed PMID: 2862565.
4: Corrigan OI, Holohan EM. Amorphous spray-dried
hydroflumethiazide-polyvinylpyrrolidone systems: physiochemical properties. J
Pharm Pharmacol. 1984 Apr;36(4):217-21. PubMed PMID: 6144766.
5: Brørs O, Braut GS, Braut S, Jacobsen S. Interaction of hydroflumethiazide and 
2,4-disulfamyl-5-trifluoromethylaniline with cyclic AMP phosphodiesterase and
carbonic anhydrase. Acta Pharmacol Toxicol (Copenh). 1982 Oct;51(4):273-7. PubMed
PMID: 6295063.
6: Brørs O, Jacobsen S. Distribution of elimination of hydroflumethiazide in man.
Eur J Clin Pharmacol. 1979 Sep;16(2):125-31. PubMed PMID: 499309.
7: Brørs O, Jacobsen S. Pharmacokinetics of hydroflumethiazide during repeated
oral administration to healthy subjects. Eur J Clin Pharmacol. 1979 May
21;15(4):281-6. PubMed PMID: 477713.
8: McNamara PJ, Colburn WA, Gibaldi M. Absorption kinetics of hydroflumethiazide.
J Clin Pharmacol. 1978 Apr;18(4):190-3. PubMed PMID: 632365.
9: Owen BJ, Wilkie SV. Separation and quantitative determination of
2,4-disulfamyl-5-trifluoromethylaniline in hydroflumethiazide using high-pressure
liquid chromatography. J Pharm Sci. 1977 Jun;66(6):877-8. PubMed PMID: 874795.
10: Smith RB, Smith RV, Yakatan GJ. Spectrofluorometric determination of
hydroflumethiazide in plasma and urine. J Pharm Sci. 1976 Aug;65(8):1208-11.
PubMed PMID: 10417.
11: Corrigan OI, Timoney RF. Anomalous behavior of some hydroflumethiazide
crystal samples. J Pharm Pharmacol. 1974 Oct;26(10):838-40. PubMed PMID: 4156551.
12: Kjaerulff J, Lyngsoe J. [The antihypertensive effects of bendroflumethiazide,
hydroflumethiazide, trichlormethiazide, chlorthalidone and furosemide]. Ugeskr
Laeger. 1973 Aug 13;135(33):1744-6. Danish. PubMed PMID: 4777951.
13: Agren A, Bäck T. Complex formation between macromolecules and drugs. 8.
Binding of saccharine, N-methyl saccharine, and the diuretic drugs
hydroflumethiazide and bendroflumethiazide to human serum albumin. Acta Pharm
Suec. 1973 Jun;10(3):223-8. PubMed PMID: 4729699.
14: Nishioeda Y. [Effect of hydroflumethiazide on the kinetics of thyroxine in
the blood]. Nihon Naibunpi Gakkai Zasshi. 1972 Jul 20;48(4):245-59. Japanese.
PubMed PMID: 4626614.
15: A spironolactone-hydroflumethiazide combination in hypertension.
Practitioner. 1971 Mar;206(233):412-5. PubMed PMID: 4929196.
16: Jamil MA. A comparative study of spironolactone and hydroflumethiazide alone 
and together in the treatment of hypertension. Guys Hosp Rep. 1971;120(3):207-19.
PubMed PMID: 4951058.
17: Williamson JM, Neilson FJ, Gibbs WN. Hypoplastic anaemia and
hydroflumethiazide. Scott Med J. 1966 Jan;11(1):19-20. PubMed PMID: 5905311.
18: PISANI E, BOSELLI G. [Clinical research with a new diuretic:
hydroflumethiazide potassium salt]. Minerva Med. 1962 Oct 24;53:3159-62. Italian.
PubMed PMID: 13943783.
19: VERTES V, KATZ JB, ROBINOW SH. Comparison of short term metabolic effects of 
hydroflumethiazide and hydrochlorothiazide. J Chronic Dis. 1962 Feb;15:171-7.
PubMed PMID: 13925585.
20: GILLHESPY RO. The antihypertensive activity of hydroflumethiazide with
Rauwolfia. J Ir Med Assoc. 1962 Feb;50:49-50. PubMed PMID: 13898651.