Synonym
Hexafluronium Bromide; Mylaxen; Hexafluorenium bromide; Milaxen; Hexafluorenium dibromide; Esafluronio bromuro; hexafluorenium dibromide salt;
IUPAC/Chemical Name
9H-fluoren-9-yl-[6-[9H-fluoren-9-yl(dimethyl)azaniumyl]hexyl]-dimethylazanium;dibromide
InChi Key
WDEFPRUEZRUYNW-UHFFFAOYSA-L
InChi Code
InChI=1S/C36H42N2.2BrH/c1-37(2,35-31-21-11-7-17-27(31)28-18-8-12-22-32(28)35)25-15-5-6-16-26-38(3,4)36-33-23-13-9-19-29(33)30-20-10-14-24-34(30)36;;/h7-14,17-24,35-36H,5-6,15-16,25-26H2,1-4H3;2*1H/q+2;;/p-2
SMILES Code
C[N+](C)(CCCCCC[N+](C)(C)C1C2=CC=CC=C2C3=CC=CC=C13)C4C5=CC=CC=C5C6=CC=CC=C46.[Br-].[Br-]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
| Solubility |
| Soluble in DMSO, not in water |
0.0 |
100.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
662.54
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Britton RM, Figueroa M. Hexafluorenium bromide: current status and a review.
Anesth Analg. 1973 Jan-Feb;52(1):100-5. Review. PubMed PMID: 4567515.
2: Radnay PA, Badola RP, Dalsania A, El-Gaweet EI, Duncalf D. Prevention of
suxamethonium-induced changes in serum potassium concentration by hexafluorenium.
Is their combined use justified? Br J Anaesth. 1979 May;51(5):447-51. PubMed
PMID: 444345.
3: Radnay PA, El-Gaweet ES, Novakovic M, Badola R, Cizmar S, Duncalf D.
Prevention of succinylcholine induced hyperkalemia by neurolept anesthesia and
hexafluorenium in anephric patients. Anaesthesist. 1981 Jul;30(7):334-7. PubMed
PMID: 6455928.
4: Scaf AH, Langendijk JW. The desensitizing interaction of hexafluorenium with
the cholinergic receptor in the diaphragm of the rat. Arch Int Pharmacodyn Ther.
1977 Feb;225(2):196-207. PubMed PMID: 849069.
5: Baraka A. Hexafluorenium-suxamethonium interaction in patients with normal
versus atypical cholinesterase. Br J Anaesth. 1975 Aug;47(8):885-8. PubMed PMID:
1201167.
6: KATZ RL, GISSEN AJ, KARIS JH. THE EFFECTS OF HEXAFLUORENIUM AND EDROPHONIUM ON
THE NEUROMUSCULAR BLOCKING ACTIONS OF SUCCINYLCHOLINE, DECAMETHONIUM, IMBRETIL
AND D-TUBOCURARINE. Anesthesiology. 1965 Mar-Apr;26:154-61. PubMed PMID:
14261050.
7: RIZZI R, GIUSSANI A. [THE COMBINATION OF HEXAFLUORENIUM, SUCCINYLCHOLINE AND
FLUOTHANE IN ANESTHESIA. PRELIMINARY NOTE]. Acta Anaesthesiol. 1964
Jan-Feb;15:53-62. Italian. PubMed PMID: 14131757.
8: VAN HEMERTV. [CHOLINESTERASE INHIBITORS IN ANESTHESIA, WITH SPECIAL REFERENCE
TO HEXAFLUORENIUM (MYLAXEN)]. Ned Tijdschr Geneeskd. 1964 Oct 3;108:1931-2.
Dutch. PubMed PMID: 14242486.
9: NASTUK WL, KARIS JH. THE BLOCKING ACTION OF HEXAFLUORENIUM ON NEUROMUSCULAR
TRANSMISSION AND ITS INTERACTION WITH SUCCINYLCHOLINE. J Pharmacol Exp Ther. 1964
May;144:236-52. PubMed PMID: 14183436.
10: MOSTERT JW, KUENDIG H. EXPERIMENTAL STUDY OF ARRHYTHMIAS AND BRONCHOSPASM
ASSOCIATED WITH THE USE OF HEXAFLUORENIUM. Br J Anaesth. 1964 Feb;36:83-93.
PubMed PMID: 14117757.
11: JOBIDON A, PARADIS B, LABRECQUE A, DOUVILLE G. [HEXAFLUORENIUM, POTENTIATOR
OF SUCCINYLCHOLINE]. Can Anaesth Soc J. 1964 Jan;11:88-100. French. PubMed PMID:
14099695.
12: MOSTERT JW. [Hexafluorenium, antagonist of hexabiscarbacholine during
anesthesia in humans]. Can Anaesth Soc J. 1963 May;10:241-3. French. PubMed PMID:
13936235.
13: SOBEL AM. Hexafluorenium, succinylcholine, and intraocular tension. Anesth
Analg. 1962 Jul-Aug;41:399-404. PubMed PMID: 13914678.
14: FOLDES FF, MOLLOY RE, ZSIGMOND EK, ZWARTZ JA. Hexafluorenium: its
anticholinesterase and neuromuscular activity. J Pharmacol Exp Ther. 1960
Aug;129:400-4. PubMed PMID: 13823697.
15: FOLDES FF, HILLMER NR, MOLLOY RE, MONTE AP. Potentiation of the neuromuscular
effect of succinylcholine by hexafluorenium. Anesthesiology. 1960
Jan-Feb;21:50-8. PubMed PMID: 13823695.
16: Schuh FR. Interaction of hexafluorenium with human plasma cholinesterase in
comparison with hexamethonium. Naunyn Schmiedebergs Arch Pharmacol.
1976;293(1):11-3. PubMed PMID: 948350.
17: Scaf AH, van den Akker J, Berends F. The interactions of hexafluorenium with
depolarizing and competitive neuromuscular blocking agents. Arch Int Pharmacodyn
Ther. 1974 Mar;208(1):166-76. PubMed PMID: 4276930.
18: Vermeer GA, Hess SW. The potentiation of the neuromuscular blocking activity
of hexafluorenium and d-tubocurarine by volatile anaesthetics. Anaesthesist. 1974
Feb;23(2):72-8. PubMed PMID: 4458482.
19: Scaf AH. The interaction of the bisquaternary ammonium compound
hexafluorenium with the histaminic receptor in the guinea-pig ileum. Eur J
Pharmacol. 1971;15(3):363-5. PubMed PMID: 4258489.
20: Walts LF, DeAngelis J, Dillon JB. Clinical studies of the interaction of
hexafluorenium and succinylcholine in man. Anesthesiology. 1970 Nov;33(5):503-7.
PubMed PMID: 4249163.
