MedKoo Cat#: 318074 | Name: Isoproterenol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isoproterenol is a medication used for the treatment of bradycardia (slow heart rate), heart block, and rarely for asthma. In humans, it is a non-selective beta-adrenergic agonist and TAAR1 agonist that is structurally similar to adrenaline.

Chemical Structure

Isoproterenol
Isoproterenol
CAS#7683-59-2 (free)

Theoretical Analysis

MedKoo Cat#: 318074

Name: Isoproterenol

CAS#: 7683-59-2 (free)

Chemical Formula: C11H17NO3

Exact Mass: 211.1208

Molecular Weight: 211.26

Elemental Analysis: C, 62.54; H, 8.11; N, 6.63; O, 22.72

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
7683-59-2 (free) 51-30-9 (HCl)
Synonym
Isoproterenol, Isoprenaline, Medihaler-Iso, Isuprel, Norisodrine, Novodrin, Isoproterenol HCl, Isoproterenol hydrochloride
IUPAC/Chemical Name
4-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol
InChi Key
JWZZKOKVBUJMES-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3
SMILES Code
OC1=CC=C(C(O)CNC(C)C)C=C1O
Appearance
White to off-white solid powder.
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 211.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Garg M, Khanna D. Exploration of pharmacological interventions to prevent isoproterenol-induced myocardial infarction in experimental models. Ther Adv Cardiovasc Dis. 2014 May 9;8(4):155-169. [Epub ahead of print] Review. PubMed PMID: 24817146. 2: Nichtova Z, Novotova M, Kralova E, Stankovicova T. Morphological and functional characteristics of models of experimental myocardial injury induced by isoproterenol. Gen Physiol Biophys. 2012 Jun;31(2):141-51. doi: 10.4149/gpb_2012_015. Review. PubMed PMID: 22781817. 3: Calkins H. Isoproterenol-provoked versus nitroglycerin-provoked tilt tests: do they differ? J Cardiovasc Electrophysiol. 2001 Jul;12(7):797-9. Review. PubMed PMID: 11469430. 4: Morrison Y, Thompson DF. Isoproterenol treatment of torsades de pointes. Ann Pharmacother. 1993 Feb;27(2):189-90. Review. PubMed PMID: 8439698. 5: Saetersdal T, Jodalen H, Lie R, Rotevatn S, Engedal H, Myklebust R. Effects of isoproterenol on the dense core and perigranular membrane of atrial specific granules. Cell Tissue Res. 1979 Jun 27;199(2):213-24. Review. PubMed PMID: 383301. 6: Weil MH. Isoproterenol for the treatment of circulatory shock. Ann Intern Med. 1969 Mar;70(3):638-41. Review. PubMed PMID: 4886923. 7: Matthews R. Isoproterenol-induced elevated bispectral indexes while undergoing radiofrequency ablation: a case report. AANA J. 2006 Jun;74(3):193-5. Review. PubMed PMID: 16786912. 8: Shubnikova EA, Pogodina LS. [Compensatory function of submandibular salivary glands in diabetes and prospects for stimulating them with isoproterenol]. Ontogenez. 2000 Nov-Dec;31(6):476-80. Review. Russian. PubMed PMID: 11153445. 9: Huang CC, Wang SJ, Gean PW. Selective enhancement of P-type calcium currents by isoproterenol in the rat amygdala. J Neurosci. 1998 Mar 15;18(6):2276-82. Review. PubMed PMID: 9482812. 10: Raybaud F, Camous JP, Jung M, Dadoun M, Baudouy M, Morand P. [Comparative data of tilt test with or without isoproterenol in investigation of unexplained unconsciousness and syncope]. Arch Mal Coeur Vaiss. 1996 Sep;89(9):1145-51. Review. French. PubMed PMID: 8952838. 11: Kataoka H. Right precordial coved ST-T segment elevation in a healthy subject evaluated by isoproterenol infusion test. A case report. Angiology. 1994 May;45(5):409-11. Review. PubMed PMID: 8172390. 12: Howard PA. Isoproterenol in the diagnosis of vasodepressor syncope. Ann Pharmacother. 1992 Sep;26(9):1097-8. Review. PubMed PMID: 1421676. 13: Victoria MS, Tayaba RG, Nangia BS. Isoproterenol infusion in the management of respiratory failure in children with status asthmaticus: experience in a small community hospital and review of the literature. J Asthma. 1991;28(2):103-8. Review. PubMed PMID: 2013558. 14: Gallagher KP. Transmural steal with isoproterenol and exercise in poststenotic myocardium. Basic Res Cardiol. 1990;85 Suppl 1:145-55. Review. PubMed PMID: 2091604. 15: Brownstein SL, Hopson RC, Martins JB, Aschoff AM, Olshansky B, Constantin L, Kienzle MG. Usefulness of isoproterenol in facilitating atrioventricular nodal reentry tachycardia during electrophysiologic testing. Am J Cardiol. 1988 May 1;61(13):1037-41. Review. PubMed PMID: 2896452. 16: Dimsdale J, Ziegler M, Graham R. The effect of hypertension, sodium, and race on isoproterenol sensitivity. Clin Exp Hypertens A. 1988;10(5):747-56. Review. PubMed PMID: 2846213. 17: Mokhtari A, Do Khac L, Tanfin Z, Harbon S. Forskolin modulates cyclic AMP generation in the rat myometrium. Interactions with isoproterenol and prostaglandins E2 and I2. J Cyclic Nucleotide Protein Phosphor Res. 1985;10(3):213-27. Review. PubMed PMID: 2991348. 18: Meerson FZ, Gomazkov OA. [Role of the sympathetic factor in the pathogenesis of myocardial infarct and isoproterenol necrosis]. Kardiologiia. 1971 Sep;11(9):140-53. Review. Russian. PubMed PMID: 4332677. 19: Collins-Williams C, Nizami R, Lamenza C. The use of isoproterenol in the treatment of the acute asthmatic attack with report of case. J Asthma Res. 1969 Sep;7(1):17-24. Review. PubMed PMID: 4898581. 20: RONA G, KAHN DS, CHAPPEL CI. STUDIES ON INFARCT-LIKE MYOCARDIAL NECROSIS PRODUCED BY ISOPROTERENOL: A REVIEW. Rev Can Biol. 1963 Jun;22:241-55. Review. PubMed PMID: 14143355.