Synonym
Gallamine Triethiodide; Flaxedil; Tricuran; Gallamoni jodidum; Gallaminii iodidum; Triethyl Iodide, Gallamine; Iodide, Gallamine; Triethyl Iodide, Gallamonium; Gallamine Triethochloride;
IUPAC/Chemical Name
2-[2,3-bis[2-(triethylazaniumyl)ethoxy]phenoxy]ethyl-triethylazanium triiodide
InChi Key
REEUVFCVXKWOFE-UHFFFAOYSA-K
InChi Code
InChI=1S/C30H60N3O3.3HI/c1-10-31(11-2,12-3)22-25-34-28-20-19-21-29(35-26-23-32(13-4,14-5)15-6)30(28)36-27-24-33(16-7,17-8)18-9;;;/h19-21H,10-18,22-27H2,1-9H3;3*1H/q+3;;;/p-3
SMILES Code
CC[N+](CC)(CC)CCOC1=C(C(=CC=C1)OCC[N+](CC)(CC)CC)OCC[N+](CC)(CC)CC.[I-].[I-].[I-]
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
891.53
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Ali AM, Ghandour MA, Abd-El-Fattah MM. Cathodic adsorptive stripping
voltammetric determination of muscle relaxant: gallamine triethiodide (flaxedil).
J Pharm Biomed Anal. 2001 Apr;25(1):31-7. PubMed PMID: 11274856.
2: Al-Jafari AA. The inhibitory effect of the neuromuscular blocking agent,
gallamine triethiodide, on camel retina acetylcholinesterase activity. Toxicol
Lett. 1997 Jan 15;90(1):45-51. PubMed PMID: 9020401.
3: Schauf CL, Smith KJ. Gallamine triethiodide-induced modifications of sodium
conductance in Myxicola giant axons. J Physiol. 1982 Feb;323:157-71. PubMed PMID:
6284914; PubMed Central PMCID: PMC1250350.
4: Ramzan MI, Triggs EJ, Shanks CA. Pharmacokinetic studies in man with gallamine
triethiodide. II. Single 4 and 6 mg/kg i.v. doses. Eur J Clin Pharmacol. 1980
Feb;17(2):145-52. PubMed PMID: 7371706.
5: Fisher MM. Anaphylactic reactions to gallamine triethiodide. Anaesth Intensive
Care. 1978 Feb;6(1):62-5. PubMed PMID: 665980.
6: Evans PJ, McKinnon I. An anaphylactoid reaction to gallamine triethiodide.
Anaesth Intensive Care. 1977 Aug;5(3):239-43. PubMed PMID: 19987.
7: Smalley N. Gallamine triethiodide. AANA J. 1975 Oct;43(5):487-91. PubMed PMID:
1043597.
8: Shembekar AG, Deshpande VR. Antiarrhythmic activity of ethosuximide and
gallamine triethiodide in experimentally induced arrhythmias. Indian J Physiol
Pharmacol. 1974 Oct-Dec;18(4):330-3. PubMed PMID: 4466791.
9: Kölliker K. The effects of pancuronium bromide and gallamine triethiodide
during barbiturate, N 2 O--halothane anaesthesia. Acta Anaesthesiol Scand.
1972;16(4):240-5. PubMed PMID: 4265584.
10: Sezaki T, Okamura H, Nakamura T, Sagara T, Matsuoka A. [Clinical study of
gallamine triethiodide in cardiotomy under simple extreme hypothermia]. Masui.
1969 Sep;18(9):863-70. Japanese. PubMed PMID: 5389154.
11: Farman JV, Kennedy BR. Circulatory effects of atropine in patients
anaesthetized with gallamine triethiodide and nitrous oxide. Br J Anaesth. 1969
Jan;41(1):38-46. PubMed PMID: 5774304.
12: Kennedy BR, Farman JV. Cardiovascular effects of gallamine triethiodide in
man. Br J Anaesth. 1968 Oct;40(10):773-80. PubMed PMID: 5698532.
13: Ascione PP, Zagar JB, Chrekian GP. Quantitative determination of gallamine
triethiodide. J Pharm Sci. 1968 Oct;57(10):1768-70. PubMed PMID: 4300952.
14: Halpern LM, Black RG. Gallamine triethiodide facilitation of local cortical
excitability compared with other neuromuscular blocking agents. J Pharmacol Exp
Ther. 1968 Jul;162(1):166-73. PubMed PMID: 5656595.
15: Halpern LM, Black RG. Evidence for a central action of gallamine triethiodide
(Flaxedil). Proc West Pharmacol Soc. 1967;10:37-8. PubMed PMID: 6055501.
16: THOMAS ET. The effect of gallamine triethiodide on blood pressure.
Anaesthesia. 1963 Jul;18:316-23. PubMed PMID: 13981064.
17: GREENFIELD W, IMIG CJ, EVONUK E. Effect of gallamine triethiodide and
pentobarbital on certain cardiovascular and respiratory events. Am J Physiol.
1961 Apr;200:801-3. PubMed PMID: 13708321.
18: MAPLESON WW, MUSHIN WM. Relaxant action in man; an experimental study. II.
Results with intravenous gallamine triethiodide. Anaesthesia. 1955
Oct;10(4):379-90. PubMed PMID: 13259126.
19: PITTINGER CB. Observations of the placental transmission of gallamine
triethiodide (flaxedil), succinylcholine chloride (anectine) and decamethonium
bromide (syncurine) in dogs. Curr Res Anesth Analg. 1955 Mar-Apr;34(2):107-11.
PubMed PMID: 14365201.
20: FOLDES FF, MACHAJ TS, CARBERRY PC. The use of gallamine triethiodide
(flaxedil) with pentothal sodium-nitrous oxide-oxygen anesthesia in abdominal
surgery. Curr Res Anesth Analg. 1954 Mar-Apr;33(2):122-8. PubMed PMID: 13141704.
