Transtinib is a potent and irreversible EGFR tyrosine kinase inhibitors (EGFR-TKIs) with activity against L858R/T790M mutant NSCLC cell lines and xenografts. Transtinib displayed strong anti-proliferative activity against the H1975 and A431 cell lines with IC50 values of 34 nM and 62 nM, respectively. In xenograft models, Transtinib significantly decreases tumor size for a prolonged period of time. Transtinib is a potential cancer therapeutic drug lead for the inhibition of mutant EGFR to overcome the development of resistance.
MedKoo Cat#: 407260
Name: Transtinib
CAS#: 1246089-27-9
Chemical Formula: C30H29ClFN5O3
Exact Mass: 561.1943
Molecular Weight: 562.04
Elemental Analysis: C, 64.11; H, 5.20; Cl, 6.31; F, 3.38; N, 12.46; O, 8.54
The following data is based on the product molecular weight 562.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
