Croconazole HCl | CAS# 77174-66-4 (HCl) | imidazole antifungal |MedKoo

MedKoo Cat#: 413350 | Name: Croconazole HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Croconazole HCl is the salt form of Croconazole, an imidazole antifungal drug, a conazole antifungal drug, a member of monochlorobenzenes and an aromatic ether.

Chemical Structure

Croconazole HCl

CAS#77174-66-4 (HCl)

Theoretical Analysis

MedKoo Cat#: 413350

Name: Croconazole HCl

CAS#: 77174-66-4 (HCl)

Chemical Formula: C18H16Cl2N2O

Exact Mass:

Molecular Weight: 347.24

Elemental Analysis: C, 62.26; H, 4.64; Cl, 20.42; N, 8.07; O, 4.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

77174-66-4 (HCl) 77175-51-0 (free base)

Synonym

Croconazole HCl; Pilzcin; Croconazole Hydrochloride

IUPAC/Chemical Name

1H-Imidazole, 1-(1-(2-((3-chlorobenzyl)oxy)phenyl)vinyl)-, monohydrochloride

InChi Key

LWJUIYYIILPRRI-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H15ClN2O.ClH/c1-14(21-10-9-20-13-21)17-7-2-3-8-18(17)22-12-15-5-4-6-16(19)11-15;/h2-11,13H,1,12H2;1H

SMILES Code

C=C(N1C=CN=C1)C2=CC=CC=C2OCC3=CC=CC(Cl)=C3.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 347.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: El-Badry M, Fetih G, Shakeel F. Comparative topical delivery of antifungal drug croconazole using liposome and micro-emulsion-based gel formulations. Drug Deliv. 2014 Feb;21(1):34-43. doi: 10.3109/10717544.2013.843610. Epub 2013 Oct 14. PMID: 24116896. 2: Shono M, Hayashi K, Sugimoto R. Allergic contact dermatitis from croconazole hydrochloride. Contact Dermatitis. 1989 Oct;21(4):225-7. doi: 10.1111/j.1600-0536.1989.tb03200.x. PMID: 2598648. 3: Beierdörffer H, Michel G, Kehr K. Croconazole in the treatment of tinea pedis. Mycoses. 1995 Nov-Dec;38(11-12):501-7. doi: 10.1111/j.1439-0507.1995.tb00028.x. PMID: 8720204. 4: Lehmann B, Wozel G, Steinmann D, Barth J. Croconazole: an inhibitor of eicosanoid synthesis in A23187-stimulated human polymorphonuclear leukocytes and human whole blood. Skin Pharmacol. 1995;8(6):326-33. doi: 10.1159/000211364. PMID: 8688199. 5: Akhtar MJ, Khan S, Roy IM, Jafri IA. High performance liquid chromatographic determination of phenoxetol, methyl paraben, ethyl paraben, n-propyl paraben, iso-butyl paraben, n-butyl paraben and croconazole.HCl. J Pharm Biomed Anal. 1996 Aug;14(11):1609-13. doi: 10.1016/0731-7085(96)01777-3. PMID: 8877869. 6: Fromtling RA. Overview of medically important antifungal azole derivatives. Clin Microbiol Rev. 1988 Apr;1(2):187-217. doi: 10.1128/cmr.1.2.187. PMID: 3069196; PMCID: PMC358042. 7: Scherr N, Röltgen K, Witschel M, Pluschke G. Screening of antifungal azole drugs and agrochemicals with an adapted alamarBlue-based assay demonstrates antibacterial activity of croconazole against Mycobacterium ulcerans. Antimicrob Agents Chemother. 2012 Dec;56(12):6410-3. doi: 10.1128/AAC.01383-12. Epub 2012 Sep 24. PMID: 23006761; PMCID: PMC3497166. 8: Steinmann A, Mayer G, Breit R, Agathos M. Allergic contact dermatitis from croconazole without cross-sensitivity to clotrimazole and bifonazole. Contact Dermatitis. 1996 Oct;35(4):255-6. doi: 10.1111/j.1600-0536.1996.tb02375.x. PMID: 8957655. 9: Meinicke K, Michel G. Croconazole: a new broad spectrum agent in the treatment of fungal skin infections. Int J Clin Pharmacol Res. 1994;14(4):139-48. PMID: 7607787. 10: Steinmann D, Barth J, Wozel G. Anti-inflammatory activity of croconazole, a broad-spectrum antimycotic agent, in the arachidonic acid-induced mouse ear swelling test. Skin Pharmacol. 1995;8(4):211-4. doi: 10.1159/000211349. PMID: 7488399.