Fluticasone furoate is a synthetic trifluorinated corticosteroid with high glucocorticoid receptor affinity, designed for enhanced topical potency and prolonged tissue retention. It exerts anti-inflammatory effects by modulating gene transcription: it upregulates anti-inflammatory proteins and downregulates pro-inflammatory cytokines through glucocorticoid response element (GRE) interactions. Fluticasone furoate displays high local activity with minimal systemic bioavailability, making it effective for once-daily treatment of respiratory and dermatologic inflammatory conditions.
MedKoo Cat#: 317898
Name: Fluticasone furoate
CAS#: 397864-44-7 (furoate)
Chemical Formula: C27H29F3O6S
Exact Mass: 538.1637
Molecular Weight: 538.58
Elemental Analysis: C, 60.21; H, 5.43; F, 10.58; O, 17.82; S, 5.95
The following data is based on the product molecular weight 538.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
