MedKoo Cat#: 319833 | Name: Lagociclovir

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lagociclovir, also known as MIV-210, is a high oral bioavailability antiviral agent with potent activity against hepatitis B virus (HBV). MIV-210 may be a highly valuable candidate for further testing as an agent against chronic hepatitis B.

Chemical Structure

Lagociclovir
Lagociclovir
CAS#92562-88-4

Theoretical Analysis

MedKoo Cat#: 319833

Name: Lagociclovir

CAS#: 92562-88-4

Chemical Formula: C10H12FN5O3

Exact Mass: 269.0924

Molecular Weight: 269.24

Elemental Analysis: C, 44.61; H, 4.49; F, 7.06; N, 26.01; O, 17.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
MIV-210; MIV 210; MIV210; 3'-FddG; Fddguo; Lagociclovir.
IUPAC/Chemical Name
2-amino-9-((2R,4S,5R)-4-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one
InChi Key
RTJUXLYUUDBAJN-KVQBGUIXSA-N
InChi Code
InChI=1S/C10H12FN5O3/c11-4-1-6(19-5(4)2-17)16-3-13-7-8(16)14-10(12)15-9(7)18/h3-6,17H,1-2H2,(H3,12,14,15,18)/t4-,5+,6+/m0/s1
SMILES Code
OC[C@@H]1[C@@H](F)C[C@H](N2C=NC3=C2N=C(N)NC3=O)O1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 269.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Michalak TI, Zhang H, Churchill ND, Larsson T, Johansson NG, Oberg B. Profound antiviral effect of oral administration of MIV-210 on chronic hepadnaviral infection in a woodchuck model of hepatitis B. Antimicrob Agents Chemother. 2009 Sep;53(9):3803-14. doi: 10.1128/AAC.00263-09. Epub 2009 Jun 29. PubMed PMID: 19564357; PubMed Central PMCID: PMC2737870. 2: De Clercq E. Emerging anti-HIV drugs. Expert Opin Emerg Drugs. 2005 May;10(2):241-73. Review. PubMed PMID: 15934866.