Forasartan | CAS#145216-43-9 | Angiotensin II Receptor Antagonist

MedKoo Cat#: 317950 | Name: Forasartan

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Forasartan is a nonpeptide angiotensin II receptor antagonist with antihypertensive activity. Forasartan competes with angiotensin II for binding at the AT1 receptor subtype in vascular smooth muscle, thereby blocking angiotensin II-mediated vasoconstriction resulting in vascular dilatation. In addition, the antagonistic effect on AT1 in the adrenal gland, prevents angiotensin II-induced stimulation of aldosterone synthesis and secretion by the adrenal cortex.

Chemical Structure

Forasartan

CAS#145216-43-9

Theoretical Analysis

MedKoo Cat#: 317950

Name: Forasartan

CAS#: 145216-43-9

Chemical Formula: C23H28N8

Exact Mass: 416.2437

Molecular Weight: 416.52

Elemental Analysis: C, 66.32; H, 6.78; N, 26.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Forasartan; SC-52458; SC 52458; SC52458.

IUPAC/Chemical Name

5-[(3,5-dibutyl-1,2,4-triazol-1-yl)methyl]-2-[2-(2H-tetrazol-5-yl)phenyl]pyridine

InChi Key

YONOBYIBNBCDSJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H28N8/c1-3-5-11-21-25-22(12-6-4-2)31(28-21)16-17-13-14-20(24-15-17)18-9-7-8-10-19(18)23-26-29-30-27-23/h7-10,13-15H,3-6,11-12,16H2,1-2H3,(H,26,27,29,30)

SMILES Code

CCCCC1=NN(C(=N1)CCCC)CC2=CN=C(C=C2)C3=CC=CC=C3C4=NNN=N4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 416.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kushiku K, Yamada H, Shibata K, Tokunaga R, Katsuragi T, Furukawa T. Upregulation of immunoreactive angiotensin II release and angiotensinogen mRNA expression by high-frequency preganglionic stimulation at the canine cardiac sympathetic ganglia. Circ Res. 2001 Jan 19;88(1):110-6. PubMed PMID: 11139482. 2: Aki Y, Tomohiro A, Nishiyama A, Kiyomoto K, Kimura S, Abe Y. The role of basally synthesized nitric oxide in modulating the renal vasoconstrictor action of angiotensin II. Hypertens Res. 1997 Dec;20(4):251-6. PubMed PMID: 9453259. 3: McMahon EG, Yang PC, Babler MA, Suleymanov OD, Palomo MA, Olins GM, Cook CS. Effects of SC-52458, an angiotensin AT1 receptor antagonist, in the dog. Am J Hypertens. 1997 Jun;10(6):671-7. PubMed PMID: 9194514. 4: Usune S, Furukawa T. Effects of SC-52458, a new nonpeptide angiotensin II receptor antagonist, on increase in cytoplasmic Ca2+ concentrations and contraction induced by angiotensin II and K(+)-depolarization in guinea-pig taenia coli. Gen Pharmacol. 1996 Oct;27(7):1179-85. PubMed PMID: 8981065. 5: Ohta K, Kim S, Hamaguchi A, Yukimura T, Miura K, Takaori K, Iwao H. Role of angiotensin II in extracellular matrix and transforming growth factor-beta 1 expression in hypertensive rats. Eur J Pharmacol. 1994 Sep 15;269(1):115-9. PubMed PMID: 7828653. 6: Olins GM, Corpus VM, Chen ST, McMahon EG, Palomo MA, McGraw DE, Smits GJ, Null CL, Brown MA, Bittner SE, et al. Pharmacology of SC-52458, an orally active, nonpeptide angiotensin AT1 receptor antagonist. J Cardiovasc Pharmacol. 1993 Oct;22(4):617-25. PubMed PMID: 7505365. 7: de la Hoz JC. [Bee (Apis mellifera, Hymenoptera: Apoidea) visitation to cantaloupe Cucumis melo (Cucurvitaceae) flowers in Panama]. Rev Biol Trop. 2007 Jun;55(2):677-80. Spanish. PubMed PMID: 19069779. 8: Krovat EM, Langer T. Non-peptide angiotensin II receptor antagonists: chemical feature based pharmacophore identification. J Med Chem. 2003 Feb 27;46(5):716-26. PubMed PMID: 12593652. 9: Katsuragi T, Sato C, Guangyuan L, Honda K. Inositol(1,4,5)trisphosphate signal triggers a receptor-mediated ATP release. Biochem Biophys Res Commun. 2002 May 3;293(2):686-90. PubMed PMID: 12054523. 10: Hagmann M, Nussberger J, Naudin RB, Burns TS, Karim A, Waeber B, Brunner HR. SC-52458, an orally active angiotensin II-receptor antagonist: inhibition of blood pressure response to angiotensin II challenges and pharmacokinetics in normal volunteers. J Cardiovasc Pharmacol. 1997 Apr;29(4):444-50. PubMed PMID: 9156352. 11: Bauer JH, Reams GP. The angiotensin II type 1 receptor antagonists. A new class of antihypertensive drugs. Arch Intern Med. 1995 Jul 10;155(13):1361-8. Review. PubMed PMID: 7794084. 12: Ohta K, Kim S, Hamaguchi A, Miura K, Yukimura T, Iwao H. Cardiac hypertrophy-related gene expression in spontaneously hypertensive rats: crucial role of angiotensin AT1 receptor. Jpn J Pharmacol. 1995 Jan;67(1):95-9. PubMed PMID: 7745853. 13: Tokunaga R, Kushiku K, Yamada K, Yamada H, Furukawa T. Possible involvement of calcium-calmodulin pathways in the positive chronotropic response to angiotensin II on the canine cardiac sympathetic ganglia. Jpn J Pharmacol. 2001 Aug;86(4):381-9. PubMed PMID: 11569611.