Synonym
AH-22216; AH22216; AH 22216
IUPAC/Chemical Name
1-(m-(3-((3-Amino-1-methyl-1H-1,2,4-triazol-5-yl)amino)propoxy)benzyl)piperidine
InChi Key
NRIGRKAXOLMTSK-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H28N6O/c1-23-18(21-17(19)22-23)20-9-6-12-25-16-8-5-7-15(13-16)14-24-10-3-2-4-11-24/h5,7-8,13H,2-4,6,9-12,14H2,1H3,(H3,19,20,21,22)
SMILES Code
CN1N=C(N)N=C1NCCCOC2=CC(CN3CCCCC3)=CC=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
344.46
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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6: Orsetti M, Sorba G. Characterization of an accessory binding area in the histamine H2 receptor. Eur J Pharmacol. 1991 Jul 12;207(3):259-65. PubMed PMID: 1680063.
7: Büyüktimkin N, Keller F, Schunack W. Gas-liquid chromatographic resolution of some racemic synthons for lamtidine analogous histamine H2-receptor antagonists via diastereomeric amides of (1S)-(-)-camphanic acid. J Chromatogr. 1989 Apr 28;467(2):402-5. PubMed PMID: 2569470.
8: Orsetti M. Histamine H2-receptor blocking activity of ranitidine and lamtidine analogues containing aminomethyl-substituted aliphatic systems. Agents Actions. 1988 Dec;25(3-4):291-5. PubMed PMID: 2905866.
9: Bonjean VJ, Schunack W. [Alkyl- and alkoxy-substituted lamtidine analogs: synthesis and H2-antagonistic activity. 38. H2-antihistaminics]. Arzneimittelforschung. 1988 Apr;38(4):501-7. German. PubMed PMID: 2900010.
10: Orsetti M, Sorba G. Pharmacological profile of new histamine H2-receptor antagonists related to cimetidine, ranitidine and lamtidine. J Pharm Pharmacol. 1988 Jan;40(1):31-4. PubMed PMID: 2896770.
11: Trumm KA, Postius S, Szelenyi I, Schunack W. [Tetrahydroisoquinolines as components of H2-antagonists. 27. H2-antihistaminics]. Arzneimittelforschung. 1986 Aug;36(8):1169-74. German. PubMed PMID: 2877673.
12: Menez I, Gespach C, Emami S, Rosselin G. Irreversible and specific inactivation by AH 22216 of histamine H2 receptors in the human gastric cancer cell line HGT-1. Biochem Biophys Res Commun. 1983 Oct 14;116(1):251-7. PubMed PMID: 6315003.
13: Gespach C, Menez I, Emami S. Potent and specific blockade by AH 22216 of histamine-H2-receptor-mediated acid secretion in isolated rabbit gastric cells. Biosci Rep. 1983 Sep;3(9):871-8. PubMed PMID: 6640083.
14: Stables R, Daly MJ, Humphray JM. Comparison of antisecretory potency and duration of action of the H2-receptor antagonists AH 22216, cimetidine, ranitidine and SK & F 93479 in the dog. Agents Actions. 1983 Apr;13(2-3):166-9. PubMed PMID: 6135321.
