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MedKoo Cat#: 317391 | Name: Cefoperazone Sodium
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cefoperazone Sodium is the sodium salt form of cefoperazone and a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity. It is marketed by Pfizer under the name Cefobid. Cefoperazone sodium inhibits bacterial cell wall synthesis by inactivating penicillin binding proteins (PBPs) thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of bacterial cell walls. This results in a reduction of cell wall stability and causes cell lysis. It is one of few cephalosporin antibiotics effective in treating Pseudomonas bacterial infections which are otherwise resistant to these antibiotics.

Chemical Structure

Cefoperazone Sodium
Cefoperazone Sodium
CAS#62893-20-3 (sodium)

Theoretical Analysis

MedKoo Cat#: 317391

Name: Cefoperazone Sodium

CAS#: 62893-20-3 (sodium)

Chemical Formula: C25H26N9NaO8S2

Exact Mass: 0.0000

Molecular Weight: 667.65

Elemental Analysis: C, 44.97; H, 3.93; N, 18.88; Na, 3.44; O, 19.17; S, 9.61

Price and Availability

Size Price Availability Quantity
1g USD 150.00 2 Weeks
2g USD 220.00 2 Weeks
5g USD 500.00 2 Weeks
10g USD 750.00 2 Weeks
25g USD 1,250.00 2 Weeks
50g USD 2,250.00 2 Weeks
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Related CAS #
62893-20-3 (sodium) 62893-19-0 (free acid)
Synonym
Cefoperazone Sodium; Sodium cefoperazone; Tomabef; T-1551; UNII-5FQG9774WD; Sodium, Cefoperazone; T 1551; T-1551; T1551; Farmasierra Brand of Cefoperazone Sodium; Pfizer Brand of Cefoperazone Sodium; Salt, Cefoperazone Sodium; Sodium Salt, Cefoperazone;
IUPAC/Chemical Name
sodium;(6R,7R)-7-[[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChi Key
NCFTXMQPRQZFMZ-WERGMSTESA-M
InChi Code
InChI=1S/C25H27N9O8S2.Na/c1-3-32-8-9-33(21(39)20(32)38)24(42)27-15(12-4-6-14(35)7-5-12)18(36)26-16-19(37)34-17(23(40)41)13(10-43-22(16)34)11-44-25-28-29-30-31(25)2;/h4-7,15-16,22,35H,3,8-11H2,1-2H3,(H,26,36)(H,27,42)(H,40,41);/q;+1/p-1/t15-,16-,22-;/m1./s1
SMILES Code
CCN1CCN(C(=O)C1=O)C(=O)N[C@H](C2=CC=C(C=C2)O)C(=O)N[C@H]3[C@@H]4N(C3=O)C(=C(CS4)CSC5=NN=NN5C)C(=O)[O-].[Na+]
Appearance
White to off-white solid powder.
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 667.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PMID: 40201540; PMCID: PMC11977545. 4: Tang Y, Chen L, Xiao J, Yan K, Qi J, Zhou K, Liu H. A single-center retrospective study of pathogen distribution and antibiotic resistance of bloodstream infections in emergency department. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2024 Nov 28;49(11):1799-1807. English, Chinese. doi: 10.11817/j.issn.1672-7347.2024.240333. PMID: 40177763; PMCID: PMC11964804. 5: Hu Y, Zhou J, Gao Y, Chen B, Su J, Li H. Deep Learning Accelerates the Development of Antimicrobial Peptides Comprising 15 Amino Acids. Assay Drug Dev Technol. 2025 Mar 27. doi: 10.1089/adt.2025.011. Epub ahead of print. PMID: 40139786. 6: Zhou L, Chen SZ, Li YY, Xue RY, Duan X, Lin XY, Chen S, Zhou D, Li HB. Gut Dysbiosis Exacerbates Intestinal Absorption of Cadmium and Arsenic from Cocontaminated Rice in Mice Due to Impaired Intestinal Barrier Functions. Environ Sci Technol. 2025 Feb 25;59(7):3459-3471. doi: 10.1021/acs.est.5c00817. Epub 2025 Feb 13. 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Toxic epidermal necrolysis following heart transplantation may caused by cefoperazone sodium and sulbactam sodium. J Cardiothorac Surg. 2024 Sep 23;19(1):542. doi: 10.1186/s13019-024-03025-x. PMID: 39307887; PMCID: PMC11418188. 11: Yang D, Hu D, Hui J, Liu Z. The clinical significance of pyogenic liver abscess after transarterial chemoembolization or microwave ablation on malignant liver tumors: A retrospective study. Medicine (Baltimore). 2024 Sep 13;103(37):e39625. doi: 10.1097/MD.0000000000039625. PMID: 39287315; PMCID: PMC11404977. 12: Deng QM, Zhang J, Zhang YY, Jia M, Ding DS, Fang YQ, Wang HZ, Gu HC. Diagnosis and treatment of refractory infectious diseases using nanopore sequencing technology: Three case reports. World J Clin Cases. 2024 Aug 6;12(22):5208-5216. doi: 10.12998/wjcc.v12.i22.5208. PMID: 39109020; PMCID: PMC11238794. 13: Xu HC, Cui Y, Wang XY, Wu HB, Li W, Wang D, Lin N, Lin L, Zhang YH. Clinical analysis of colistin sulfate in the treatment of pneumonia caused by carbapenem- resistant Gram-negative bacteria. World J Clin Cases. 2024 May 6;12(13):2173-2181. doi: 10.12998/wjcc.v12.i13.2173. Retraction in: World J Clin Cases. 2024 Jul 6;12(19):4029-4030. doi: 10.12998/wjcc.v12.i19.4029. PMID: 38808336; PMCID: PMC11129130. 14: Chen H, Zhang Y, Pan Y, Wu L, Wang W, Zhang H, Lou H. Antibiotic-induced microbiome depletion promotes intestinal colonization by Campylobacter jejuni in mice. BMC Microbiol. 2024 May 9;24(1):156. doi: 10.1186/s12866-024-03313-5. PMID: 38724913; PMCID: PMC11080253. 15: Guo RQ, Yang J, Yang YB, Chen YN, Xiao YY, Xiang P, Dong MJ, He MF, Wang YT, Xiao YL, Ke HQ, Liu H. Spectrum and antibiotic sensitivity of bacterial keratitis: a retrospective analysis of eight years in a Tertiary Referral Hospital in Southwest China. Front Cell Infect Microbiol. 2024 Mar 11;14:1363437. doi: 10.3389/fcimb.2024.1363437. PMID: 38529473; PMCID: PMC10961451. 16: Lu Y, Wu HL, Luo ZJ. Long-term debridement effect of denervated large sacrococcygeal pressure injury: A case report. Medicine (Baltimore). 2024 Jan 26;103(4):e37012. doi: 10.1097/MD.0000000000037012. PMID: 38277574; PMCID: PMC10817163. 17: And Alternative Medicine EC. Retracted: Polymyxin B, Cefoperazone Sodium- Sulbactam Sodium, and Tigecycline against Multidrug-Resistant Acinetobacter baumannii Pneumonia. Evid Based Complement Alternat Med. 2023 Dec 13;2023:9821412. doi: 10.1155/2023/9821412. PMID: 38125170; PMCID: PMC10732887. 18: Ye J, Li J, Wang X, Wang Q, Wang S, Wang H, Zhu H, Xu J. Preparation of bacterial cellulose-based antibacterial membranes with prolonged release of drugs: Emphasis on the chemical structure of drugs. Carbohydr Polym. 2024 Jan 1;323:121379. doi: 10.1016/j.carbpol.2023.121379. Epub 2023 Sep 12. PMID: 37940275. 19: He JL, Liu XY, Zhang Y, Niu L, Li XL, Xie XY, Kang YT, Yang LQ, Cai ZY, Long H, Ye GF, Zou JX. 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