AL082D06, also known as D-06, is a nonsteroidal glucocorticoid receptor antagonist. AL082D06 binds specifically to GR with no measurable binding affinity to the progesterone receptor. AL082D06 binds with nanomolar affinity to the GR and has no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins. AL082D06 inhibits glucocorticoid-mediated transcriptional regulation. AL082D06 binds competitively with steroids, likely occupying a similar site within the ligand-binding domain.
MedKoo Cat#: 522627
Name: AL082D06
CAS#: 256925-03-8
Chemical Formula: C23H24ClN3O2
Exact Mass: 409.1557
Molecular Weight: 409.91
Elemental Analysis: C, 67.39; H, 5.90; Cl, 8.65; N, 10.25; O, 7.81
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.3 | 15.25 | |
| DMF | 10.0 | 24.40 | |
| DMF:PBS (pH 7.2) (1:2) | 0.3 | 0.81 |
The following data is based on the product molecular weight 409.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
