Synonym
CH 402; CH402; CH-402.
IUPAC/Chemical Name
4-Quinolinemethanesulfonic acid, 1,2-dihydro-2,2-dimethyl-, monosodium salt
InChi Key
QZSGYPOMAGZIOZ-UHFFFAOYSA-M
InChi Code
InChI=1S/C12H15NO3S.Na/c1-12(2)7-9(8-17(14,15)16)10-5-3-4-6-11(10)13-12;/h3-7,13H,8H2,1-2H3,(H,14,15,16);/q;+1/p-1
SMILES Code
[Na+].N1C(C=C(c2ccccc12)CS(=O)(=O)[O-])(C)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
275.30
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Vereckei A, Blazovics A, Gyorgy I, Feher E, Toth M, Szenasi G, Zsinka A, Foldiak G, Feher J. The role of free radicals in the pathogenesis of amiodarone toxicity. J Cardiovasc Electrophysiol. 1993 Apr;4(2):161-77. PubMed PMID: 8269288.
2: Prònai L, Blåzovics A, Horvåth M, Lång I, Fehér J. The superoxide scavenging activity of dihydroquinoline type derivatives (CH402 and MTDQ-DA). Free Radic Res Commun. 1993;19(5):287-96. PubMed PMID: 8314109.
3: Vereckei A, Blázovics A, Szénási G, Kónya L, Láng I, Zsinka A, Fehér J. [The role of oxidative stress, caused by amiodarone, in the side effects of the drug]. Orv Hetil. 1991 Mar 3;132(9):483-4, 487-8. Review. Hungarian. PubMed PMID: 2003039.
4: Blázovics A, György I, Zsinka AJ, Biacs P, Földiák G, Feher J. In vitro scavenger effect of dihydroquinoline type derivatives in different free radical generating systems. Free Radic Res Commun. 1989;6(4):217-26. PubMed PMID: 2553547.
5: Blázovics A, Somogyi A, Ambrus D, Mathiász D, Vereckei A, Fehér J. The effect of CH 402 dihydroquinoline type antioxidant on the activity of Na+-K+-ATP-ase and Mg++-ATP-ase of rat brain subcellular fractions in the presence and absence of ascorbic acid. Acta Physiol Hung. 1989;73(1):3-7. PubMed PMID: 2540618.
6: Blázovics A, Somogyi A, Lengyel G, Láng I, Fehér J. Inhibition of lipid peroxidation by dihydroquinoline-type antioxidant (CH 402). Free Radic Res Commun. 1988;4(6):409-13. PubMed PMID: 3243505.
