MedKoo Cat#: 317379 | Name: Cefaclor
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cefaclor is a beta-lactam, second-generation cephalosporin antibiotic that inhibits cell wall synthesis. The antibiotic is active against a wide spectrum of common pathogens, including gram-positive and gram-negative bacteria. Cefaclor binds to and inactivates penicillin-binding proteins (PBP) located in bacterial cytoplasmic membranes. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity.

Chemical Structure

Cefaclor
Cefaclor
CAS#53994-73-3 (free)

Theoretical Analysis

MedKoo Cat#: 317379

Name: Cefaclor

CAS#: 53994-73-3 (free)

Chemical Formula: C15H14ClN3O4S

Exact Mass: 367.0394

Molecular Weight: 367.81

Elemental Analysis: C, 48.98; H, 3.84; Cl, 9.64; N, 11.42; O, 17.40; S, 8.72

Price and Availability

Size Price Availability Quantity
1g USD 350.00 2 Weeks
5g USD 550.00 2 Weeks
10g USD 750.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Synonym
Cefaclor; Ceclor; Cefaclorum; Cephaclor; Raniclor; Kefral; S6472; Cefaclor Anhydrous; Cefaclor Monohydrate; Keclor; Lilly 99638; Monohydrate, Cefaclor; S 6472; S-6472;
IUPAC/Chemical Name
(6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
InChi Key
QYIYFLOTGYLRGG-GPCCPHFNSA-N
InChi Code
InChI=1S/C15H14ClN3O4S/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23)/t9-,10-,14-/m1/s1
SMILES Code
C1C(=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=CC=C3)N)C(=O)O)Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 367.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Blanc CH, Meyer-Brunot HG, Tosch W, Schelling JL. [Serum and joint levels of cefacetrile during its administration for septic arthritis]. Schweiz Med Wochenschr. 1978 Jul 1;108(26):988-94. French. PubMed PMID: 663591. 2: Yoshida M, Nonoshita Y, Saito S, Hyon U, Henmi T. [Stability of sulbenicillin and cefacetrile in bile (author's transl)]. Jpn J Antibiot. 1980 Apr;33(4):472-7. Japanese. PubMed PMID: 7411851. 3: Oto T, Yoshida M, Ueno H, Nishikawa M, Hayashi R. [A clinical study of cefacetrile in the treatment for orthopedic infections (author's transl)]. Jpn J Antibiot. 1977 Jul;30(7):484-7. Japanese. PubMed PMID: 909136. 4: Brogard JM, Dorner M, Brandt C, Lavillaureix J. Cephacetrile--application of pharmacokinetic data to dosage determination. Int J Clin Pharmacol Biopharm. 1976 Apr;13(3):168-76. PubMed PMID: 950258. 5: Nakai Y, Kanai Y, Fugono T, Tanayama S. Metabolic fate of cephacetrile after parenteral administration in rats and rabbits. J Antibiot (Tokyo). 1976 Jan;29(1):81-90. PubMed PMID: 931795. 6: Venturini AP, Stanzani L, Mantovani V, Mascellani G. [In vitro and in vivo antibacterial activity of combined flucloxacillin-cefacetrile (Flunicef)]. G Ital Chemioter. 1979 Jan-Dec;26(1-2):153-8. Italian. PubMed PMID: 554805. 7: Bals MG, Toma E. Cephacetrile, a new cephalosporin: in vitro, pharmacological and clinical evaluation. Infection. 1975;3(3):161-4. PubMed PMID: 4377. 8: Esposti G, Esposti D, Guerino G, Bichisao E, Fraschini F. Effects of cephacetrile on reproduction cycle. Arzneimittelforschung. 1986 Mar;36(3):484-6. PubMed PMID: 3707668. 9: Dominguez-Gil A, Lanao JM, Tabernero JM, Rodriguez Commes JL, de Castro S. Pharmacokinetics of cephacetrile in patients undergoing haemodialysis. Eur J Clin Pharmacol. 1979 Aug;16(1):49-52. PubMed PMID: 499300. 10: Windorfer A, Gasteiger U. Studies on serum and cerebrospinal fluid levels of cephacetrile in neonates. Infection. 1977;5(4):242-7. PubMed PMID: 598930. 11: Aratani H, Nakatsuka M. [Fundamental studies on combination of antibiotics; especially on pharmacokinetics. I. Combination of gentamicin with sulbenicillin or cephacetrile (author's transl)]. Jpn J Antibiot. 1976 Dec;29(12):1019-34. Japanese. PubMed PMID: 1051432. 12: Ishigami J, Mita T, Tanikaze S, Fujii A, Kuroda M. [Comparative results of cephacetrile with cefazolin in complicated urinary tract infections by means of double-blind trials (author's transl)]. Jpn J Antibiot. 1976 Dec;29(12):1052-69. Japanese. PubMed PMID: 796485. 13: Matsumoto K, Noguchi Y, Uzuka Y, Kato Y, Saito A. [A clinical evaluation of the effect of cephacetrile on bacterial pneumonia. A comparative test with cefazolin by a double blind method (author's transl)]. Jpn J Antibiot. 1976 Dec;29(12):1070-92. Japanese. PubMed PMID: 796486. 14: Horiuchi N, Oyakawa Y, Oka R, Fujiwara T. [Clinical evaluation of cephacetrile (Celtol) for respiratory infections (author's transl)]. Jpn J Antibiot. 1980 Oct;33(10):1145-55. Japanese. PubMed PMID: 7206219. 15: Mangia A, Silingardi S, Bortesi F, Grisanti G, Di Bitetto M. High-performance liquid chromatographic determination of cephacetrile. J Pharm Sci. 1979 May;68(5):652-4. PubMed PMID: 430511. 16: Gallais H, Raoult D, Kohler JL, Vischer WA, Casanova P. [Dosage of cephacetrile in blood and CSF in ten purulent meningitis ]. Pathol Biol (Paris). 1982 Jun;30(6 Pt 2):526-8. French. PubMed PMID: 6750520. 17: Shibuya H, Miyawaki J, Matsuyoshi T, Anai K, Kawano Y, Onimura S, Takizawa S, Akaiwa H, Asao M. [Cephacetrile. Studies on absorption excretion and diffusion into heart (author's transl)]. Jpn J Antibiot. 1980 Oct;33(10):1138-44. Japanese. PubMed PMID: 7206218. 18: Fee WH Jr, Winter LW, Bright TP, Smith JW, Farber MO, Bartram CE. Cephacetrile in the treatment of acute bacterial pneumonia. Curr Ther Res Clin Exp. 1975 May;17(5):419-26. PubMed PMID: 236153. 19: Ziv G, Nouws JF. Clinical pharmacology of cephacetrile in ruminants. Zentralbl Veterinarmed B. 1977 Dec;24(10):798-811. PubMed PMID: 602527. 20: Blanc CH. [Plasma and articular concentrations during administration of cephacetrile for septic arthritis]. Z Unfallmed Berufskr. 1979;72(3):118-21. French. PubMed PMID: 543327.